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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

DOI :

10.3791/52621-v

April 28th, 2015

April 28th, 2015

10,119 Views

1The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center, 2Fischell Department of Bioengineering, University of Maryland, 3Department of Radiology, George Washington University, 4Department of Pediatrics, George Washington University

This protocol describes the synthesis of biofunctionalized Prussian blue nanoparticles and their use as multimodal, molecular imaging agents. The nanoparticles have a core-shell design where gadolinium or manganese ions within the nanoparticle core generate MRI contrast. The biofunctional shell contains fluorophores for fluorescence imaging and targeting ligands for molecular targeting.

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Keywords Biofunctionalized Prussian Blue Nanoparticles

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