Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

21.4K Views

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09:11 min

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February 23rd, 2016

DOI :

10.3791/53106-v

February 23rd, 2016

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Christina Wayman*¹^,², Denise A. Duricki*¹^,², Lisa A. Roy³, Barbara Haenzi¹, Shi-Yen Tsai⁴, Gwendolyn Kartje⁴^,⁵^,⁶, John S. Beech⁷, Diana Cash², Lawrence Moon¹

¹Wolfson Centre for Age-Related Diseases, King's College London, University of London, ²Department of Neuroimaging, James Black Centre, Institute of Psychiatry, King's College London, University of London, ³Institute of Neuroscience and Psychology, Wellcome Surgical Institute, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, ⁴Research Service, Edward Hines Jr. VA Hospital, ⁵Neurology Service, Edward Hines Jr. VA Hospital, ⁶Department of Molecular Pharmacology and Therapeutics, Neuroscience Research Institute, Loyola University Chicago, ⁷Department of Oncology, The Gray Institute for Radiation, Oncology and Biology, University of Oxford

Summary

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Keywords Permanent Middle Cerebral Artery Occlusion

Carotid Artery Occlusion

Common Carotid Artery

Vagus Nerve

Cortical Ischemia

Stroke Model

Chapters in this video

0:05

Title

1:03

Stroke Surgery

6:48

Confirmation of Infarct and Sample Size Calculation

7:39

Results: Representative Micro and Macroanatomical Effects of MCA Occlusion on Cerebral Function in the Elderly Rat

8:32

Conclusion

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