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JoVE Journal

Medicine

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Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension

20.6K Views

09:40 min

April 11th, 2016

April 11th, 2016

20,621 Views

0:05

Title

0:43

Echocardiography

2:48

Right Heart Catheterization

4:45

Open-chest Right Ventricle Pressure-volume Loop Analysis

6:24

Heart and Lung Sample Collection

7:58

Results: Representative Pulmonary Arterial Hypertension Data in Rodent Models

8:49

Conclusion

Transcript

The overall goal of echocardiography and right heart catheretization in rodents is to determine the function of the right heart in various cardiac and pulmonary disease models. This method can help answer key questions in cardiovascular physiology

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Pulmonary arterial hypertension (PAH) is a disease of pulmonary arterioles that leads to their obliteration and the development of right ventricular failure. Rodent models of PAH are critical in understanding the pathophysiology of PAH. Here we demonstrate hemodynamic characterization, with right heart catheterization and echocardiography, in the mouse and rat.

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