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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

DOI :

10.3791/53589-v

January 26th, 2016

January 26th, 2016

11,602 Views

1Department of Chemical and Systems Biology, Stanford University School of Medicine

A simple and general method for the synthesis of cyclic peptides using microwave irradiation is outlined. This procedure enables the synthesis of backbone cyclic peptides with a collection of different conformations while retaining the side chains and the pharmacophoric moieties., and therefore, allows to screen for the bioactive conformation.

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Backbone Cyclic Peptide Library

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