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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

DOI :

10.3791/51299-v

June 20th, 2014

June 20th, 2014

17,731 Views

1Scripps Florida, The Scripps Research Institute

Peptide tertiary amides (PTAs) are a superfamily of peptidomimetics that include but are not limited to peptides, peptoids and N-methylated peptides. Here we describe a synthetic method which combines both split-and-pool and sub-monomer strategies to synthesize a one-bead one-compound library of PTAs.

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Split and pool Synthesis

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