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A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

DOI :

10.3791/54298-v

July 16th, 2016

July 16th, 2016

10,974 Views

1Department of Medicine, Division of Endocrinology, Stanford University School of Medicine

Critical challenges for the diabetes research field are to understand the molecular mechanisms that regulate islet β-cell replication and to develop methods for stimulating β-cell regeneration. Herein a high-content screening method to identify and assess the β-cell replication-promoting activity of small molecules is presented.

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