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Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

DOI :

10.3791/54755-v

November 24th, 2016

November 24th, 2016

9,041 Views

1Department of Surgery, University of California, Los Angeles, 2Molecular Biology Institute, University of California, Los Angeles, 3Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles

Understanding the cellular and molecular mechanisms of re-endothelialization following arterial denudation injury is of paramount importance in preventing thrombosis and restenosis of arteries. Here we describe a protocol for reproducible arterial denudation injury of the infrarenal abdominal aorta. The procedure was developed to investigate the underlying mechanisms that regulate endothelial regeneration using mouse models.

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Reproducible

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