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Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse

DOI :

10.3791/55174-v

April 2nd, 2017

April 2nd, 2017

9,436 Views

1Department of Otorhinolaryngology, Head and Neck Surgery "Otto Koerner", Rostock University Medical Center, 2Department of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, 3Institute for Experimental Surgery, Rostock University Medical Center

The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.

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Intravital Microscopy

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