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Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

DOI :

10.3791/50329-v

April 2nd, 2013

April 2nd, 2013

15,432 Views

1Department of Pharmacology, University of Illinois at Chicago , 2Department of Anesthesiology, University of Illinois at Chicago

Here we report an experimental technique of fluorescence intravital microscopy to visualize heterotypic platelet-neutrophil interactions on the activated endothelium during vascular inflammation and thrombus formation in live mice. This microscopic technology will be valuable to study the molecular mechanism of vascular disease and to test pharmacologic agents under pathophysiological conditions.

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