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A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

DOI :

10.3791/51329-v

April 10th, 2014

April 10th, 2014

38,019 Views

1Davis Heart & Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University

We introduce a surgical method to induce experimental ischemia/reperfusion (I/R) injury to simulate myocardial infarction (MI) in mouse models that allows for more clarity in positioning of the ligation on the left anterior descending artery (LAD) to increase the reproducibility of MI experiments in mice.

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Murine Model

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