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The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

DOI :

10.3791/55532-v

May 8th, 2017

May 8th, 2017

8,879 Views

1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 2Department of Mechanical and Aerospace Engineering, University of California, San Diego

The mucus plugged airways of cystic fibrosis (CF) patients are an ideal environment for microbial pathogens to thrive. The manuscript describes a novel method for studying the CF lung microbiome in an environment that mimics where they cause disease and how alterations of chemical conditions can drive microbial dynamics.

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