An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury

9.4K Views

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09:25 min

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December 31st, 2017

DOI :

10.3791/56565-v

December 31st, 2017

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Chen Chen¹^,², Yi Ping Zhang³, Yan Sun¹^,⁴, Wenhui Xiong¹, Lisa B. E. Shields³, Christopher B. Shields³^,⁵, Xiaoming Jin¹, Xiao-Ming Xu¹

¹Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, and Department of Neurological Surgery, Indiana University School of Medicine, ²Program in Medical Neuroscience, Stark Neurosciences Research Institute, Indiana University School of Medicine, ³Norton Neuroscience Institute, Norton Healthcare, ⁴Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, ⁵Department of Neurological Surgery, University of Louisville School of Medicine

Summary

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Contusive Spinal Cord Injury

Neuroprotective Strategies

Vascular Repair

Sprague Dawley Rat

External Jugular Vein

Catheter

Spinal Cord Injury

Chapters in this video

0:05

Title

1:22

External Jugular Vein Catheterization

3:09

Spine Stabilization, C5 - C7 Laminectomy, and Two-photon (2P) Imaging Window Installation

5:02

First Fluorescent Dye Injection and Baseline Imaging

6:25

Louisville System Apparatus (LISA) Device-induced C7 Contusive Injury, Second Fluorescent Dye Injection, and Post-injury Imaging

7:26

Results: Representative In Vivo Vascular Dynamic Imaging Following Contusive Spinal Cord Injury

8:27

Conclusion

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