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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution

DOI :

10.3791/59130-v

4:14 min

April 16th, 2019

April 16th, 2019

11,119 Views

1Cardiovascular, Renal and Metabolic Diseases, MedImmune, 2Laboratory Animal Resources, MedImmune

In clinical settings, a liver biopsy is used to assess stages of non-alcoholic steatohepatitis (steatosis, inflammation, hepatocyte ballooning, and fibrosis). Here, we illustrate a survivable liver biopsy in mice which can be used for histological analyses to enable assessment of therapeutic agents in a manner more aligned with clinical trials.

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Survivable Liver Biopsy Procedure

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