Name: measuring the complete-arch distortion of an optical dental impression
Uploaded: 2019-05-30T13:00:00
Description: Watch this Scientific Journal Video about Measuring the Complete-arch Distortion of an Optical Dental Impression at JoVE.com

This study was supported by a grant of the Korea Health Technology R&#38;D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health &#38; Welfare (grant number: HI18C0435).

1. Master specimen preparation
<ol>
	<li>Model preparation
	<ol>
		<li>Remove the artificial teeth (left and right canines, second premolar, and the second molar) on the mandibular complete-arch model with only 1/5 of the cervical portion left.</li>
	</ol>
	</li>
	<li>CAD design
	<ol>
		<li>Acquire the data of the master specimen with a reference scanner.</li>
		<li>Design the cylinders (with a top diameter of 2 mm and a cylinder height of 7 mm) on top of the trimmed six teeth with the...

<ol>
	<li>McLean, J. W., von Fraunhofer, J. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+estimation+of+cement+film+thickness+by+an+in+vivo+technique.">The estimation of cement film thickness by an in vivo technique.</a> British Dental Journal. 131 (3), 107-111 (1971).</li><li>Park, J. M., Hong, Y. S., Park, E. J., Heo, S. J., Oh, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinical+evaluations+of+cast+gold+alloy,+machinable+zirconia,+and+semiprecious+alloy+crowns:+A+multicenter+study.">Clinical evaluations of cast gold alloy, machinable zirconia, and semiprecious alloy crowns: A multicenter study.</a> Journal of Prosthetic Dentistry. 115 (6), 684-691 (2016).</li><li>Keul, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Fit+of+4-unit+FDPs+made+of+zirconia+and+CoCr-alloy+after+chairside+and+labside+digitalization--a+laboratory+study.">Fit of 4-unit FDPs made of zirconia and CoCr-alloy after chairside and labside digitalization--a laboratory study.</a> Dental Materials. 30 (4), 400-407 (2014).</li><li>Ritter, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+chairside-milled+CAD/CAM+drill+guides+for+dental+implants.">Accuracy of chairside-milled CAD/CAM drill guides for dental implants.</a> International Journal of Computerized Dentistry. 17 (2), 115-124 (2014).</li><li>Grunheid, T., McCarthy, S. D., Larson, B. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinical+use+of+a+direct+chairside+oral+scanner:+an+assessment+of+accuracy,+time,+and+patient+acceptance.">Clinical use of a direct chairside oral scanner: an assessment of accuracy, time, and patient acceptance.</a> American Journal of Orthodontics and Dentofacial Orthopedics. 146 (5), 673-682 (2014).</li><li>Penarrocha-Oltra, D., Agustin-Panadero, R., Bagan, L., Gimenez, B., Penarrocha, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Impression+of+multiple+implants+using+photogrammetry:+description+of+technique+and+case+presentation.">Impression of multiple implants using photogrammetry: description of technique and case presentation.</a> Medicina Oral, Patolodia Oral y Cirugia Bucal. 19 (4), e366-e371 (2014).</li><li>Kattadiyil, M. T., Mursic, Z., AlRumaih, H., Goodacre, C. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intraoral+scanning+of+hard+and+soft+tissues+for+partial+removable+dental+prosthesis+fabrication.">Intraoral scanning of hard and soft tissues for partial removable dental prosthesis fabrication.</a> Journal of Prosthetic Dentistry. 112 (3), 444-448 (2014).</li><li>Kim, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+experience+curves+between+two+3-dimensional+intraoral+scanners.">Comparison of experience curves between two 3-dimensional intraoral scanners.</a> Journal of Prosthetic Dentistry. 116 (2), 221-230 (2016).</li><li>Lim, J. H., Park, J. M., Kim, M., Heo, S. J., Myung, J. Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+digital+intraoral+scanner+reproducibility+and+image+trueness+considering+repetitive+experience.">Comparison of digital intraoral scanner reproducibility and image trueness considering repetitive experience.</a> Journal of Prosthetic Dentistry. 119 (2), 225-232 (2018).</li><li>Muhlemann, S., Greter, E. A., Park, J. M., Hammerle, C. H. F., Thoma, D. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Precision+of+digital+implant+models+compared+to+conventional+implant+models+for+posterior+single+implant+crowns:+A+within-subject+comparison.">Precision of digital implant models compared to conventional implant models for posterior single implant crowns: A within-subject comparison.</a> Clinical Oral Implants Research. 29 (9), 931-936 (2018).</li><li>Park, J. M., Hammerle, C. H. F., Benic, G. I. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Digital+technique+for+in+vivo+assessment+of+internal+and+marginal+fit+of+fixed+dental+prostheses.">Digital technique for in vivo assessment of internal and marginal fit of fixed dental prostheses.</a> Journal of Prosthetic Dentistry. 118 (4), 452-454 (2017).</li><li>Ender, A., Zimmermann, M., Attin, T., Mehl, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=In+vivo+precision+of+conventional+and+digital+methods+for+obtaining+quadrant+dental+impressions.">In vivo precision of conventional and digital methods for obtaining quadrant dental impressions.</a> Clinical Oral Investigations. 20 (7), 1495-1504 (2016).</li><li>Kim, R. J., Park, J. M., Shim, J. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+9+intraoral+scanners+for+complete-arch+image+acquisition:+A+qualitative+and+quantitative+evaluation.">Accuracy of 9 intraoral scanners for complete-arch image acquisition: A qualitative and quantitative evaluation.</a> Journal of Prosthetic Dentistry. 120 (6), 895-903 (2018).</li><li>Ender, A., Mehl, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+in+dental+medicine,+a+new+way+to+measure+trueness+and+precision.">Accuracy in dental medicine, a new way to measure trueness and precision.</a> Journal of Visualized Experiments. (86), e51374 (2014).</li><li>Ender, A., Mehl, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=In-vitro+evaluation+of+the+accuracy+of+conventional+and+digital+methods+of+obtaining+full-arch+dental+impressions.">In-vitro evaluation of the accuracy of conventional and digital methods of obtaining full-arch dental impressions.</a> Quintessence International. 46 (1), 9-17 (2015).</li><li>Ajioka, H., Kihara, H., Odaira, C., Kobayashi, T., Kondo, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Examination+of+the+Position+Accuracy+of+Implant+Abutments+Reproduced+by+Intra-Oral+Optical+Impression.">Examination of the Position Accuracy of Implant Abutments Reproduced by Intra-Oral Optical Impression.</a> PLOS ONE. 11 (10), e0164048 (2016).</li><li>Patzelt, S. B., Lamprinos, C., Stampf, S., Att, W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+time+efficiency+of+intraoral+scanners:+an+in+vitro+comparative+study.">The time efficiency of intraoral scanners: an in vitro comparative study.</a> Journal of Americal Dental Association. 145 (6), 542-551 (2014).</li><li>Gan, N., Xiong, Y., Jiao, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+Intraoral+Digital+Impressions+for+Whole+Upper+Jaws,+Including+Full+Dentitions+and+Palatal+Soft+Tissues.">Accuracy of Intraoral Digital Impressions for Whole Upper Jaws, Including Full Dentitions and Palatal Soft Tissues.</a> PLOS ONE. 11 (7), e0158800 (2016).</li><li>Rehmann, P., Sichwardt, V., Wostmann, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intraoral+Scanning+Systems:+Need+for+Maintenance.">Intraoral Scanning Systems: Need for Maintenance.</a> International Journal of Prosthodontics. 30 (1), 27-29 (2017).</li><li>Patzelt, S. B., Emmanouilidi, A., Stampf, S., Strub, J. R., Att, W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+full-arch+scans+using+intraoral+scanners.">Accuracy of full-arch scans using intraoral scanners.</a> Clinical Oral Investigations. 18 (6), 1687-1694 (2014).</li><li>Muallah, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+full-arch+scans+using+intraoral+and+extraoral+scanners:+an+in+vitro+study+using+a+new+method+of+evaluation.">Accuracy of full-arch scans using intraoral and extraoral scanners: an in vitro study using a new method of evaluation.</a> International Journal of Computerized Dentistry. 20 (2), 151-164 (2017).</li><li>Treesh, J. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Complete-arch+accuracy+of+intraoral+scanners.">Complete-arch accuracy of intraoral scanners.</a> Journal of Prosthetic Dentistry. 120 (3), 382-388 (2018).</li><li>Patzelt, S. B., Vonau, S., Stampf, S., Att, W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessing+the+feasibility+and+accuracy+of+digitizing+edentulous+jaws.">Assessing the feasibility and accuracy of digitizing edentulous jaws.</a> Journal of Americal Dental Association. 144 (8), 914-920 (2013).</li><li>Andriessen, F. S., Rijkens, D. R., van der Meer, W. J., Wismeijer, D. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Applicability+and+accuracy+of+an+intraoral+scanner+for+scanning+multiple+implants+in+edentulous+mandibles:+a+pilot+study.">Applicability and accuracy of an intraoral scanner for scanning multiple implants in edentulous mandibles: a pilot study.</a> Journal of Prosthetic Dentistry. 111 (3), 186-194 (2014).</li><li>Gimenez, B., Ozcan, M., Martinez-Rus, F., Pradies, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+a+digital+impression+system+based+on+parallel+confocal+laser+technology+for+implants+with+consideration+of+operator+experience+and+implant+angulation+and+depth.">Accuracy of a digital impression system based on parallel confocal laser technology for implants with consideration of operator experience and implant angulation and depth.</a> International Journal of Oral and Maxillofacial Implants. 29 (4), 853-862 (2014).</li><li>Gimenez, B., Ozcan, M., Martinez-Rus, F., Pradies, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+a+digital+impression+system+based+on+active+wavefront+sampling+technology+for+implants+considering+operator+experience,+implant+angulation,+and+depth.">Accuracy of a digital impression system based on active wavefront sampling technology for implants considering operator experience, implant angulation, and depth.</a> Clinical Implant Dentistry and Related Research. 17 Suppl 1, e54-e64 (2015).</li><li>Papaspyridakos, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Digital+versus+conventional+implant+impressions+for+edentulous+patients:+accuracy+outcomes.">Digital versus conventional implant impressions for edentulous patients: accuracy outcomes.</a> Clinical Oral Implants Research. 27 (4), 465-472 (2016).</li><li>Flugge, T. V., Att, W., Metzger, M. C., Nelson, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Precision+of+Dental+Implant+Digitization+Using+Intraoral+Scanners.">Precision of Dental Implant Digitization Using Intraoral Scanners.</a> International Journal of Prosthodontics. 29 (3), 277-283 (2016).</li><li>Kim, S. Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Accuracy+of+dies+captured+by+an+intraoral+digital+impression+system+using+parallel+confocal+imaging.">Accuracy of dies captured by an intraoral digital impression system using parallel confocal imaging.</a> International Journal of Prosthodontics. 26 (2), 161-163 (2013).</li><li>Ender, A., Mehl, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Influence+of+scanning+strategies+on+the+accuracy+of+digital+intraoral+scanning+systems.">Influence of scanning strategies on the accuracy of digital intraoral scanning systems.</a> International Journal of Computerized Dentistry. 16 (1), 11-21 (2013).</li></ol>

Among the studies evaluating the accuracy of the intraoral scanner by evaluating the resultant digital impression body, the most common method is to superimpose the digital impression data on the reference image and calculate the shell-to-shell deviation12,13,14,15,20,23. However, this method is limited to calculating the dev...

In the traditional dental treatment process, a fixed restoration or a removable denture is made on a model made of gypsum and impregnated with a silicone or irreversible hydrocolloid material. Because an indirectly made prosthesis is delivered in the oral cavity, a lot of research has been done to overcome the errors caused by a series of such manufacturing processes1,2. Recently, a digital method is used to fabricate a prosthesis through the CAD process by manipulating models in the virtual space after acquiring 3D images instead of making impressions3. In the early days, such an optical impression method was used in a limited range such as a dental caries treatment of one or a small number of teeth. However, as the base technology of the 3D scanner was developed, a digital impression for the complete arch is now used for the fabrication of large-scale fixed restorations, removable restorations such as a partial or full denture, orthodontic appliances, and implant surgical guides4,5,6,7. The accuracy of the digital impression is satisfactory in a short region such as the unilateral arch. However, since the intraoral scanner is a handheld device that completes the entire dentition by stitching together the image obtained through a narrow optical window, the distortion of the model can be seen after completing the U-shaped dental arch. Thus, an appliance of a large range made on this model might not fit well in the patient&#39;s mouth and require a lot of adjustment.
Various studies have been reported on the accuracy of the virtual impression body obtained with an intraoral scanner, and there are various research models and measurement methods. Depending on the research subject, it can be divided into clinical research8,9,10,11,12 for actual patients and in vitro studies13,14,15,16 conducted in models separately produced for research. Clinical studies have the advantage of being able to evaluate the conditions of an actual clinical setting, but it is difficult to control the variables and increase the number of clinical cases indefinitely. The number of clinical studies is not large because there is a limit to being able to evaluate the desired variables. On the other hand, many in vitro studies that evaluate the basic performance of the intraoral scanner by controlling variables have been reported17. The research model also includes a partial or complete arch of natural teeth18,19,20,21,22 and a fully edentulous jaw with all teeth lost23, or the case where the dental implant is installed and spaced apart at a certain interval24,25,26,27, or a form in which the majority of the teeth remain and only a part of a tooth is missing16,28. However, studies on the distortion of the virtual impression body made by a handheld intraoral scanner have been limited to the qualitative evaluation of deviations through a color map created by superimposing it with reference data and expressed as one numerical value per data. It is difficult to accurately measure the 3D distortion of the complete arch because most studies only examine the localized portion of the dental arch with a nondirectional distance deviation.
In this study, the distortion of the dental arch during optical impression with an intraoral scanner is investigated by using a standard model with a coordinate system. The aim of this study is to provide information on a method for evaluating the accuracy performance of the intraoral scanners which exhibit various characteristics by the difference in optical hardware and processing software.

<table>
	<tbody>
		<tr>
			<td>EOS CobaltChrome SP2</td>
			<td>Electro Oprical Systems</td>
			<td>H051601</td>
			<td>Powder type metal alloy for 3D printing</td>
		</tr>
		<tr>
			<td>Geomagic Verify</td>
			<td>3D Systems</td>
			<td>2015.2.0</td>
			<td>3D inspection software</td>
		</tr>
		<tr>
			<td>Prosthetic Restoration Jaw Model</td>
			<td>Nissin Dental Products Inc.</td>
			<td></td>
			<td>Mandibular complete-arch model</td>
		</tr>
		<tr>
			<td>Rapidform</td>
			<td>Inus technology</td>
			<td>RF90600-10004-010000</td>
			<td>Reverse engineering software</td>
		</tr>
		<tr>
			<td>stereoSCAN R8</td>
			<td>AICON 3D Systems GmbH</td>
			<td></td>
			<td>Industrial-level model scanner</td>
		</tr>
	</tbody>
</table>

measuring the complete-arch distortion of an optical dental impression

Digital workflows have actively been used to produce dental restorations or oral appliances since dentists started to make digital impressions by acquiring 3D images with an intraoral scanner. Because of the nature of scanning the oral cavity in the patient&#39;s mouth, the intraoral scanner is a handheld device with a small optical window, stitching together small data to complete the entire image. During the complete-arch impression procedure, a deformation of the impression body can occur and affect the fit of the restoration or appliance. In order to measure these distortions, a master specimen was designed and produced with a metal 3D printer. Designed reference geometries allow setting independent coordinate systems for each impression and measure x, y, and z displacements of the cylinder top circle center where the distortion of the impression can be evaluated. In order to evaluate the reliability of this method, the coordinate values of the cylinder are calculated and compared between the original computer-aided design (CAD) data and the reference data acquired with the industrial scanner. The coordinate differences between the two groups were mostly less than 50 &#181;m, but the deviations were high due to the tolerance of 3D printing in the z coordinates of the obliquely designed cylinder on the molar. However, since the printed model sets a new standard, it does not affect the results of the test evaluation. The reproducibility of the reference scanner is 11.0 &#177; 1.8 &#181;m. This test method can be used to identify and improve upon the intrinsic problems of an intraoral scanner or to establish a scanning strategy by measuring the degree of distortion at each part of the complete-arch digital impression.

The coordinates of each cylinder calculated from the originally designed CAD data and the reference scan image of the 3D-printed metal master specimen scanned by the industrial-level model scanner are shown in Table 1. The difference between the two showed a value of lower than 50 &#181;m, but the z coordinate value of the right second molar cylinder from the 3D-printed master specimen was low. Although the metal phantom was produced from a high-end industrial 3D...

Watch this Scientific Journal Video about Measuring the Complete-arch Distortion of an Optical Dental Impression at JoVE.com

Measuring the Complete-arch Distortion of an Optical Dental Impression

Here, we present a protocol to measure the degree of distortion at each part of the compete-arch digital impression acquired from an intraoral scanner with 3D-printed metal phantom with standard geometries.

Digital workflows have actively been used to produce dental restorations or oral appliances since dentists started to make digital impressions by ...

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