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High-Frequency Ultrasound Echocardiography to Assess Zebrafish Cardiac Function

DOI :

10.3791/60976-v

March 12th, 2020

March 12th, 2020

7,913 Views

1Stanford Cardiovascular Institute, Stanford University, 2Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School

We describe a protocol to assess heart morphology and function in adult zebrafish using high-frequency echocardiography. The method allows visualization of the heart and subsequent quantification of functional parameters, such as heart rate (HR), cardiac output (CO), fractional area change (FAC), ejection fraction (EF), and blood inflow and outflow velocities.

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