Anthony A. High
St. Jude Proteomics Facility,
Center for Proteomics and Metabolomics
St. Jude Children's Research Hospital
I am the Director of the Center for Proteomics and Metabolomics at St. Jude Children’s Research Hospital in Memphis, Tennessee. I hold a Ph.D. degree in Chemistry from the University of Virginia and received my postdoctoral training in mass spectrometry at the Louis Pasteur University in Strasbourg, France. I have been conducting research at St. Jude Children’s Research Hospital for more than 17 years. In each of these positions, I have provided specialized expertise to other investigators on problems related to protein chemistry and proteomics. I have also pursued my own research in the development of mass spectrometry techniques to aid in protein quantitation. I have published over 50 research articles and papers in peer-reviewed scientific journals. I have been serving as a reviewer for more than 8 different scientific journals. I am a member of several scientific societies, including the Association of Biomolecular Resource Facilities (ABRF) and the American Society of Mass Spectrometry (ASMS).
Large-scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome.
Journal of proteome research Jan, 2009 | Pubmed ID: 19067583
Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19398558
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
Journal of proteome research Feb, 2010 | Pubmed ID: 20020773
The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.
The Journal of biological chemistry Oct, 2011 | Pubmed ID: 21896478
A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2011 | Pubmed ID: 22011580
HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans.
Development (Cambridge, England) May, 2013 | Pubmed ID: 23578927
Hematopoietic progenitor cell lines with myeloid and lymphoid potential.
Nature methods Aug, 2013 | Pubmed ID: 23749299
Identification and characterization of phosphorylation sites within the pregnane X receptor protein.
Biochemical pharmacology Jan, 2014 | Pubmed ID: 24184507
Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor.
Journal of virology Aug, 2014 | Pubmed ID: 24899174
Integrated approaches for analyzing U1-70K cleavage in Alzheimer's disease.
Journal of proteome research Nov, 2014 | Pubmed ID: 24902715
Quantitative protein analysis by mass spectrometry.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25859956
Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.
Journal of molecular biology Mar, 2016 | Pubmed ID: 26475525
Deep Profiling of Proteome and Phosphoproteome by Isobaric Labeling, Extensive Liquid Chromatography, and Mass Spectrometry.
Methods in enzymology , 2017 | Pubmed ID: 28109439
Extensive Peptide Fractionation and y1 Ion-Based Interference Detection Method for Enabling Accurate Quantification by Isobaric Labeling and Mass Spectrometry.
Analytical chemistry Mar, 2017 | Pubmed ID: 28194965
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.
Science signaling 08, 2018 | Pubmed ID: 30108181
Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer's disease.
Clinical proteomics , 2019 | Pubmed ID: 31019427
Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes.
Nature communications 08, 2019 | Pubmed ID: 31420543
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Neuron 03, 2020 | Pubmed ID: 31926610
Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry.
Journal of proteome research 01, 2021 | Pubmed ID: 33175545
Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
High-throughput and Deep-proteome Profiling by 16-plex Tandem Mass Tag Labeling Coupled with Two-dimensional Chromatography and Mass Spectrometry
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