Anthony J. Koleske

Department of Molecular Biophysics and Biochemistry, Yale University

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2021

Other Publications

Article	Year
Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron\| PubMed ID: 9883720	1998
The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11752434	2001
Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity. Journal of neurophysiology\| PubMed ID: 12626632	2003
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Molecular and cellular biology\| PubMed ID: 12748290	2003
Do filopodia enable the growth cone to find its way? Science's STKE : signal transduction knowledge environment\| PubMed ID: 12759482	2003
How do Abl family kinases regulate cell shape and movement? Trends in cell biology\| PubMed ID: 14729179	2004
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Molecular and cellular biology\| PubMed ID: 14993293	2004
Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase. Current biology : CB\| PubMed ID: 15084284	2004
The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. The Journal of cell biology\| PubMed ID: 15138293	2004
Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15987940	2005
Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Molecular biology of the cell\| PubMed ID: 16971514	2006
A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation. Current biology : CB\| PubMed ID: 17306540	2007
The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Molecular biology of the cell\| PubMed ID: 17652459	2007
Dissecting kinase signaling pathways. Drug discovery today\| PubMed ID: 17826684	2007
Use of a chemical genetic technique to identify myosin IIb as a substrate of the Abl-related gene (Arg) tyrosine kinase. Biochemistry\| PubMed ID: 17892306	2007
Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17928439	2007
The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood\| PubMed ID: 18305217	2008
Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms. The Journal of biological chemistry\| PubMed ID: 18796434	2008
T cell survival and function requires the c-Abl tyrosine kinase. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19098427	2008
Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. The Journal of cell biology\| PubMed ID: 19414610	2009
N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor. The Journal of biological chemistry\| PubMed ID: 19679652	2009
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. The Journal of cell biology\| PubMed ID: 19704022	2009
Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts. Journal of cell science\| PubMed ID: 19759284	2009
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805386	2009
Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp. Biochemistry\| PubMed ID: 20146487	2010
Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20220006	2010
Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders. Annual review of neuroscience\| PubMed ID: 20367247	2010
Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration. Journal of Alzheimer's disease : JAD\| PubMed ID: 20413901	2010
The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts. Cytoskeleton (Hoboken, N.J.)\| PubMed ID: 20737438	2010
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20823226	2010
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. Journal of cell science\| PubMed ID: 20971703	2010
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer research\| PubMed ID: 21257711	2011
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 21339745	2011
Cell adhesion signaling pathways: First responders to cocaine exposure? Communicative & integrative biology\| PubMed ID: 21509173	2011
Invadopodia: RhoC runs rings around cofilin. Current biology : CB\| PubMed ID: 21514509	2011
ErbB4 localization to interneurons: clearer insights into schizophrenia pathology. Biological psychiatry\| PubMed ID: 21924131	2011
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. The Journal of cell biology\| PubMed ID: 22105349	2011
Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22297987	2012
Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22357865	2012
Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22396406	2012
Cortactin in cell migration and cancer at a glance. Journal of cell science\| PubMed ID: 22566665	2012
The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection. Molecular and cellular biology\| PubMed ID: 22665498	2012
Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Oncogene\| PubMed ID: 22777352	2013
Arg/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin. Biochemistry\| PubMed ID: 22849492	2012
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. Journal of hepatology\| PubMed ID: 22889954	2012
Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice. The Journal of comparative neurology\| PubMed ID: 23047754	2013
A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase. Chembiochem : a European journal of chemical biology\| PubMed ID: 23081945	2012
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23185000	2012
Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23365224	2013
Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23407965	2013
β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. Molecular biology of the cell\| PubMed ID: 23552693	2013
Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23595732	2013
WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. PloS one\| PubMed ID: 23691243	2013
Molecular mechanisms of dendrite stability. Nature reviews. Neuroscience\| PubMed ID: 23839597	2013
Arg kinase signaling in dendrite and synapse stabilization pathways: memory, cocaine sensitivity, and stress. The international journal of biochemistry & cell biology\| PubMed ID: 23916785	2013
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron\| PubMed ID: 24012003	2013
Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex. The Journal of comparative neurology\| PubMed ID: 24752666	2014
Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin. The Journal of biological chemistry\| PubMed ID: 24891505	2014
Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood. Frontiers in neuroanatomy\| PubMed ID: 25368556	2014
ECM receptors in neuronal structure, synaptic plasticity, and behavior. Progress in brain research\| PubMed ID: 25410355	2014
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors. Frontiers in pharmacology\| PubMed ID: 25452728	2014
Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin. The Journal of biological chemistry\| PubMed ID: 25540195	2015
Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase. The Journal of biological chemistry\| PubMed ID: 25694433	2015
Structure of the ABL2/ARG kinase in complex with dasatinib. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 25849507	2015
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease. Alzheimer's research & therapy\| PubMed ID: 25874001	2015
SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia. Biological psychiatry\| PubMed ID: 26296424	2015
Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27335408	2016
The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. Journal of cell science\| PubMed ID: 27358479	2016
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. Journal of neuroscience research\| PubMed ID: 27735056	2017
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. The Journal of clinical investigation\| PubMed ID: 27797343	2016
Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells. Molecular biology of the cell\| PubMed ID: 28356423	2017
Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity. ACS chemical neuroscience\| PubMed ID: 28418645	2017
Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR. Angewandte Chemie (International ed. in English)\| PubMed ID: 28679029	2017
Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity. Human molecular genetics\| PubMed ID: 28973398	2017
CNS Neurons Deposit Laminin α5 to Stabilize Synapses. Cell reports\| PubMed ID: 29091766	2017
Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Molecular and cellular neurosciences\| PubMed ID: 29107098	2017
The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions. The Journal of allergy and clinical immunology\| PubMed ID: 29157947	2018
The repeat region of cortactin is intrinsically disordered in solution. Scientific reports\| PubMed ID: 29196701	2017
Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry\| PubMed ID: 29341593	2018
A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 29550892	2018
Cortactin stabilization of actin requires actin-binding repeats and linker, is disrupted by specific substitutions, and is independent of nucleotide state. The Journal of biological chemistry\| PubMed ID: 29929984	2018
Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell death and differentiation\| PubMed ID: 29988075	2019
Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function. Cell reports\| PubMed ID: 30089263	2018
Abl2 is recruited to ventral actin waves through cytoskeletal interactions to promote lamellipodium extension. Molecular biology of the cell\| PubMed ID: 30256707	2018
Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits. Cell reports\| PubMed ID: 30840899	2019
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. The Journal of clinical investigation\| PubMed ID: 31408443	2019
Regulation of MT dynamics via direct binding of an Abl family kinase. The Journal of cell biology\| PubMed ID: 31699690	2019
Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors? The Journal of physiology\| PubMed ID: 32034761	2021
ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Gastroenterology\| PubMed ID: 32171747	2020
Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold. Neuron\| PubMed ID: 32707082	2020
Two-color nanoscopy of organelles for extended times with HIDE probes. Nature communications\| PubMed ID: 32848153	2020
Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen . Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33184172	2020
Trio family proteins as regulators of cell migration and morphogenesis in development and disease - mechanisms and cellular contexts. Journal of cell science\| PubMed ID: 33568469	2021
Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 33622779	2021
Regulation of the NMDA receptor by its cytoplasmic domains: (How) is the tail wagging the dog? Neuropharmacology\| PubMed ID: 34097949	2021
Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation. The Journal of biological chemistry\| PubMed ID: 34144039	2021
Arg Deficiency Does not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis. Journal of clinical & cellular immunology\| PubMed ID: 34527426	2016