Department of Molecular Biophysics and Biochemistry,
Department of Neuroscience
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Essential roles for the Abl and Arg tyrosine kinases in neurulation.
Neuron Dec, 1998 | Pubmed ID: 9883720
The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2001 | Pubmed ID: 11752434
Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity.
Journal of neurophysiology Mar, 2003 | Pubmed ID: 12626632
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
Molecular and cellular biology Jun, 2003 | Pubmed ID: 12748290
Do filopodia enable the growth cone to find its way?
Science's STKE : signal transduction knowledge environment May, 2003 | Pubmed ID: 12759482
How do Abl family kinases regulate cell shape and movement?
Trends in cell biology Jan, 2004 | Pubmed ID: 14729179
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
Molecular and cellular biology Mar, 2004 | Pubmed ID: 14993293
Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase.
Current biology : CB Apr, 2004 | Pubmed ID: 15084284
The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion.
The Journal of cell biology May, 2004 | Pubmed ID: 15138293
Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2005 | Pubmed ID: 15987940
Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.
Molecular biology of the cell Nov, 2006 | Pubmed ID: 16971514
A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.
Current biology : CB Mar, 2007 | Pubmed ID: 17306540
The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin.
Molecular biology of the cell Oct, 2007 | Pubmed ID: 17652459
Dissecting kinase signaling pathways.
Drug discovery today Sep, 2007 | Pubmed ID: 17826684
Use of a chemical genetic technique to identify myosin IIb as a substrate of the Abl-related gene (Arg) tyrosine kinase.
Biochemistry Oct, 2007 | Pubmed ID: 17892306
Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2007 | Pubmed ID: 17928439
The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse.
Blood Jul, 2008 | Pubmed ID: 18305217
Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.
The Journal of biological chemistry Nov, 2008 | Pubmed ID: 18796434
T cell survival and function requires the c-Abl tyrosine kinase.
Cell cycle (Georgetown, Tex.) Dec, 2008 | Pubmed ID: 19098427
Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion.
The Journal of cell biology May, 2009 | Pubmed ID: 19414610
N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19679652
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.
The Journal of cell biology Aug, 2009 | Pubmed ID: 19704022
Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts.
Journal of cell science Oct, 2009 | Pubmed ID: 19759284
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2009 | Pubmed ID: 19805386
Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp.
Biochemistry Mar, 2010 | Pubmed ID: 20146487
Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2010 | Pubmed ID: 20220006
Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders.
Annual review of neuroscience , 2010 | Pubmed ID: 20367247
Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20413901
The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts.
Cytoskeleton (Hoboken, N.J.) Oct, 2010 | Pubmed ID: 20737438
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2010 | Pubmed ID: 20823226
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.
Journal of cell science Nov, 2010 | Pubmed ID: 20971703
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.
Cancer research Mar, 2011 | Pubmed ID: 21257711
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Laboratory investigation; a journal of technical methods and pathology May, 2011 | Pubmed ID: 21339745
Cell adhesion signaling pathways: First responders to cocaine exposure?
Communicative & integrative biology Jan, 2011 | Pubmed ID: 21509173
Invadopodia: RhoC runs rings around cofilin.
Current biology : CB Apr, 2011 | Pubmed ID: 21514509
ErbB4 localization to interneurons: clearer insights into schizophrenia pathology.
Biological psychiatry Oct, 2011 | Pubmed ID: 21924131
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.
The Journal of cell biology Nov, 2011 | Pubmed ID: 22105349
Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.
Acta crystallographica. Section F, Structural biology and crystallization communications Feb, 2012 | Pubmed ID: 22297987
Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2012 | Pubmed ID: 22357865
Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2012 | Pubmed ID: 22396406
Cortactin in cell migration and cancer at a glance.
Journal of cell science Apr, 2012 | Pubmed ID: 22566665
The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.
Molecular and cellular biology Aug, 2012 | Pubmed ID: 22665498
Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo.
Oncogene May, 2013 | Pubmed ID: 22777352
Arg/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin.
Biochemistry Aug, 2012 | Pubmed ID: 22849492
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver.
Journal of hepatology Dec, 2012 | Pubmed ID: 22889954
Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice.
The Journal of comparative neurology Apr, 2013 | Pubmed ID: 23047754
A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.
Chembiochem : a European journal of chemical biology Nov, 2012 | Pubmed ID: 23081945
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2012 | Pubmed ID: 23185000
Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2013 | Pubmed ID: 23365224
Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2013 | Pubmed ID: 23407965
β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation.
Molecular biology of the cell Jun, 2013 | Pubmed ID: 23552693
Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2013 | Pubmed ID: 23595732
WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl.
PloS one , 2013 | Pubmed ID: 23691243
Molecular mechanisms of dendrite stability.
Nature reviews. Neuroscience Aug, 2013 | Pubmed ID: 23839597
Arg kinase signaling in dendrite and synapse stabilization pathways: memory, cocaine sensitivity, and stress.
The international journal of biochemistry & cell biology Nov, 2013 | Pubmed ID: 23916785
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.
Neuron Sep, 2013 | Pubmed ID: 24012003
Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex.
The Journal of comparative neurology Oct, 2014 | Pubmed ID: 24752666
Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin.
The Journal of biological chemistry Jul, 2014 | Pubmed ID: 24891505
Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood.
Frontiers in neuroanatomy , 2014 | Pubmed ID: 25368556
ECM receptors in neuronal structure, synaptic plasticity, and behavior.
Progress in brain research , 2014 | Pubmed ID: 25410355
Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors.
Frontiers in pharmacology , 2014 | Pubmed ID: 25452728
Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin.
The Journal of biological chemistry Feb, 2015 | Pubmed ID: 25540195
Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.
The Journal of biological chemistry Mar, 2015 | Pubmed ID: 25694433
Structure of the ABL2/ARG kinase in complex with dasatinib.
Acta crystallographica. Section F, Structural biology communications Apr, 2015 | Pubmed ID: 25849507
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.
Alzheimer's research & therapy , 2015 | Pubmed ID: 25874001
SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia.
Biological psychiatry Sep, 2015 | Pubmed ID: 26296424
Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 06, 2016 | Pubmed ID: 27335408
The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Journal of cell science 08, 2016 | Pubmed ID: 27358479
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development.
Journal of neuroscience research 05, 2017 | Pubmed ID: 27735056
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.
The Journal of clinical investigation Dec, 2016 | Pubmed ID: 27797343
Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.
Molecular biology of the cell May, 2017 | Pubmed ID: 28356423
Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.
ACS chemical neuroscience 07, 2017 | Pubmed ID: 28418645
Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR.
Angewandte Chemie (International ed. in English) 08, 2017 | Pubmed ID: 28679029
Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity.
Human molecular genetics 12, 2017 | Pubmed ID: 28973398
CNS Neurons Deposit Laminin α5 to Stabilize Synapses.
Cell reports Oct, 2017 | Pubmed ID: 29091766
Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase.
Molecular and cellular neurosciences 12, 2017 | Pubmed ID: 29107098
The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions.
The Journal of allergy and clinical immunology 10, 2018 | Pubmed ID: 29157947
The repeat region of cortactin is intrinsically disordered in solution.
Scientific reports 12, 2017 | Pubmed ID: 29196701
Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase.
Biochemistry 02, 2018 | Pubmed ID: 29341593
A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 06, 2018 | Pubmed ID: 29550892
Cortactin stabilization of actin requires actin-binding repeats and linker, is disrupted by specific substitutions, and is independent of nucleotide state.
The Journal of biological chemistry 08, 2018 | Pubmed ID: 29929984
Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.
Cell death and differentiation 03, 2019 | Pubmed ID: 29988075
Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function.
Cell reports 08, 2018 | Pubmed ID: 30089263
Abl2 is recruited to ventral actin waves through cytoskeletal interactions to promote lamellipodium extension.
Molecular biology of the cell 11, 2018 | Pubmed ID: 30256707
Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.
Cell reports 03, 2019 | Pubmed ID: 30840899
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis.
The Journal of clinical investigation 08, 2019 | Pubmed ID: 31408443
Regulation of MT dynamics via direct binding of an Abl family kinase.
The Journal of cell biology 12, 2019 | Pubmed ID: 31699690
Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors?
The Journal of physiology 01, 2021 | Pubmed ID: 32034761
ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice.
Gastroenterology 07, 2020 | Pubmed ID: 32171747
Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold.
Neuron 09, 2020 | Pubmed ID: 32707082
Two-color nanoscopy of organelles for extended times with HIDE probes.
Nature communications 08, 2020 | Pubmed ID: 32848153
Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen .
Proceedings of the National Academy of Sciences of the United States of America 12, 2020 | Pubmed ID: 33184172
Trio family proteins as regulators of cell migration and morphogenesis in development and disease - mechanisms and cellular contexts.
Journal of cell science 02, 2021 | Pubmed ID: 33568469
Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool.
The Journal of neuroscience : the official journal of the Society for Neuroscience 04, 2021 | Pubmed ID: 33622779
Regulation of the NMDA receptor by its cytoplasmic domains: (How) is the tail wagging the dog?
Neuropharmacology 09, 2021 | Pubmed ID: 34097949
Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.
The Journal of biological chemistry 07, 2021 | Pubmed ID: 34144039
Arg Deficiency Does not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis.
Journal of clinical & cellular immunology , 2016 | Pubmed ID: 34527426
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