Anthony J. Koleske

Essential roles for the Abl and Arg tyrosine kinases in neurulation.

The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin.

Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity.

Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.

Do filopodia enable the growth cone to find its way?

How do Abl family kinases regulate cell shape and movement?

Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.

Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase.

The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion.

Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.

Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.

A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.

The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin.

Dissecting kinase signaling pathways.

Use of a chemical genetic technique to identify myosin IIb as a substrate of the Abl-related gene (Arg) tyrosine kinase.

Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.

The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse.

Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.

T cell survival and function requires the c-Abl tyrosine kinase.

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion.

N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor.

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.

Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts.

Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine.

Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp.

Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation.

Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders.

Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.

The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts.

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.

The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.

Cell adhesion signaling pathways: First responders to cocaine exposure?

Invadopodia: RhoC runs rings around cofilin.

ErbB4 localization to interneurons: clearer insights into schizophrenia pathology.

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.

Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.

Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior.

Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.

Cortactin in cell migration and cancer at a glance.

The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.

Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo.

Arg/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin.

Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver.

Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice.

A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.

Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding.

Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways.

Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience.

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation.

Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior.

WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl.

Molecular mechanisms of dendrite stability.

Arg kinase signaling in dendrite and synapse stabilization pathways: memory, cocaine sensitivity, and stress.

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.

Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex.

Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin.

Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood.

ECM receptors in neuronal structure, synaptic plasticity, and behavior.

Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors.

Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin.

Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.

Structure of the ABL2/ARG kinase in complex with dasatinib.

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia.

Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice.

The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.

Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development.

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.

Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.

Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR.

Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity.

CNS Neurons Deposit Laminin α5 to Stabilize Synapses.

Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase.

The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions.

The repeat region of cortactin is intrinsically disordered in solution.

Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase.

A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation.

Cortactin stabilization of actin requires actin-binding repeats and linker, is disrupted by specific substitutions, and is independent of nucleotide state.

Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.

Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function.

Abl2 is recruited to ventral actin waves through cytoskeletal interactions to promote lamellipodium extension.

Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.

Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis.

Regulation of MT dynamics via direct binding of an Abl family kinase.

Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors?

ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice.

Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold.

Two-color nanoscopy of organelles for extended times with HIDE probes.

Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen .

Trio family proteins as regulators of cell migration and morphogenesis in development and disease - mechanisms and cellular contexts.

Abl2:Cortactin Interactions Regulate Dendritic Spine Stability via Control of a Stable Filamentous Actin Pool.

Regulation of the NMDA receptor by its cytoplasmic domains: (How) is the tail wagging the dog?

Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.

Arg Deficiency Does not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis.