John M. Hawdon

Department of Microbiology, The George Washington University

Affiliated withThe George Washington University

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2022

Other Publications

Article	Year
A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. Molecular and biochemical parasitology\| PubMed ID: 11897134	2002
Molecular cloning of a novel multidomain Kunitz-type proteinase inhibitor from the hookworm Ancylostoma caninum. The Journal of parasitology\| PubMed ID: 12760667	2003
The second messenger cyclic GMP mediates activation in Ancylostoma caninum infective larvae. International journal for parasitology\| PubMed ID: 12865078	2003
Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum. International journal for parasitology\| PubMed ID: 12906874	2003
Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. International journal for parasitology\| PubMed ID: 13678639	2003
Phosphoinositide-3-OH-kinase inhibitor LY294002 prevents activation of Ancylostoma caninum and Ancylostoma ceylanicum third-stage infective larvae. International journal for parasitology\| PubMed ID: 15217729	2004
Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum. International journal for parasitology\| PubMed ID: 15313130	2004
Cloning and characterisation of an aspartyl protease inhibitor (API-1) from Ancylostoma hookworms. International journal for parasitology\| PubMed ID: 15722082	2005
Identification of a DAF-7 ortholog from the hookworm Ancylostoma caninum. International journal for parasitology\| PubMed ID: 16135366	2005
Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum. Infection and immunity\| PubMed ID: 16177370	2005
Introduction of Gerhard A. Schad as the recipient of the Clark P. Read Mentor Award. The Journal of parasitology\| PubMed ID: 16539001	2005
Molecular cloning and DNA binding characterization of DAF-16 orthologs from Ancylostoma hookworms. International journal for parasitology\| PubMed ID: 18930062	2009
Interaction of hookworm 14-3-3 with the forkhead transcription factor DAF-16 requires intact Akt phosphorylation sites. Parasites & vectors\| PubMed ID: 19393088	2009
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19497877	2009
Identification of hookworm DAF-16/FOXO response elements and direct gene targets. PloS one\| PubMed ID: 20808816	2010
Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation. International journal for parasitology\| PubMed ID: 21172351	2011
RNA and protein synthesis is required for Ancylostoma caninum larval activation. Veterinary parasitology\| PubMed ID: 21354706	2011
Controlling soil-transmitted helminths: time to think inside the box? The Journal of parasitology\| PubMed ID: 24393037	2014
Genome of the human hookworm Necator americanus. Nature genetics\| PubMed ID: 24441737	2014
Two potential hookworm DAF-16 target genes, SNR-3 and LPP-1: gene structure, expression profile, and implications of a cis-regulatory element in the regulation of gene expression. Parasites & vectors\| PubMed ID: 25573064	2015
Expression profile of heat shock response factors during hookworm larval activation and parasitic development. Molecular and biochemical parasitology\| PubMed ID: 26296769	2015
RNAi-mediated gene knockdown by microinjection in the model entomopathogenic nematode Heterorhabditis bacteriophora. Parasites & vectors\| PubMed ID: 26993791	2016
Acceptance of the 2016 Henry Baldwin Ward Medal - A Long and Winding Road to a Diet of Worms. The Journal of parasitology\| PubMed ID: 27529653	2016
Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research. International journal for parasitology. Drugs and drug resistance\| PubMed ID: 27751868	2016
Identification of candidate infection genes from the model entomopathogenic nematode Heterorhabditis bacteriophora. BMC genomics\| PubMed ID: 28049427	2017
Refined ab initio gene predictions of Heterorhabditis bacteriophora using RNA-seq. International journal for parasitology\| PubMed ID: 29530648	2018
Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development. Open forum infectious diseases\| PubMed ID: 29780848	2018
Introduction of James "Sparky" Lok, Recipient of the 2018 Bueding and Von Brand Lectureship Award. The Journal of parasitology\| PubMed ID: 30086247	2018
Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum. International journal for parasitology\| PubMed ID: 30771359	2019
Presidential Address: Hookworm and the ASP-A Presidential Perspective. The Journal of parasitology\| PubMed ID: 31999235	2019
Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism. International journal for parasitology\| PubMed ID: 32592811	2020
A putative UDP-glycosyltransferase from Heterorhabditis bacteriophora suppresses antimicrobial peptide gene expression and factors related to ecdysone signaling. Scientific reports\| PubMed ID: 32704134	2020
A putative lysozyme and serine carboxypeptidase from Heterorhabditis bacteriophora show differential virulence capacities in Drosophila melanogaster. Developmental and comparative immunology\| PubMed ID: 32791175	2021
NemChR-DB: a database of parasitic nematode chemosensory G-protein coupled receptors. International journal for parasitology\| PubMed ID: 33275943	2021
Secreted virulence factors from Heterorhabditis bacteriophora highlight its utility as a model parasite among Clade V nematodes. International journal for parasitology\| PubMed ID: 33421438	2021
Chemogenomic approach to identifying nematode chemoreceptor drug targets in the entomopathogenic nematode Heterorhabditis bacteriophora. Computational biology and chemistry\| PubMed ID: 33667976	2021
Controlled Infection of Humans with the Hookworm Parasite Necator americanus to Accelerate Vaccine Development : The Human Hookworm Vaccination/Challenge Model (HVCM). Current topics in microbiology and immunology\| PubMed ID: 34328562	2021