Alexander S. Mosig

Institute of Biochemistry II, Jena University Hospital

Affiliated withJena University Hospital Friedrich Schiller University Friedrich Schiller University Jena

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

Article Total : 2	Year
Publication title	2024
Publication title	2024

Other Publications

Article	Year
A microfluidically perfused three dimensional human liver model. Biomaterials\| PubMed ID: 26322723	2015
A human macrophage-hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica. BMC microbiology\| PubMed ID: 26739172	2016
Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model. Scientific reports\| PubMed ID: 26902749	2016
Recruitment of CD16(+) monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine. Cytokine\| PubMed ID: 27031442	2016
An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development. Biomicrofluidics\| PubMed ID: 27478526	2016
Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 27586188	2016
High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pr... Journal of the American Heart Association\| PubMed ID: 28096099	2017
Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase. Biochemical pharmacology\| PubMed ID: 28189727	2017
Organ-on-chip models: new opportunities for biomedical research. Future science OA\| PubMed ID: 28670461	2017
Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer. International journal of cancer\| PubMed ID: 28670762	2017
Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency. Journal of tissue engineering\| PubMed ID: 28890781	2017
Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage. Advanced healthcare materials\| PubMed ID: 28960916	2018
Functional Analyses of RUNX3 and CaMKIINα in Ovarian Cancer Cell Lines Reveal Tumor-Suppressive Functions for CaMKIINα and Dichotomous Roles for RUNX3 Transcript Variants. International journal of molecular sciences\| PubMed ID: 29342962	2018
Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development. Advanced drug delivery reviews\| PubMed ID: 29908880	2019
β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages. Frontiers in immunology\| PubMed ID: 30555483	2018
CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an Liver-on-Chip Model. Frontiers in immunology\| PubMed ID: 30873161	2019
A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials\| PubMed ID: 31398556	2019
Keeping commensal: how lactobacilli antagonize pathogenicity of in an gut model. Disease models & mechanisms\| PubMed ID: 31413153	2019
The Peroxisome Proliferator-Activated Receptor (PPAR)- Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPAR and Induces Lipogenesis and Triglycerid... Molecular pharmacology\| PubMed ID: 31871304	2020
Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication\| PubMed ID: 31994489	2020
VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1. Cells\| PubMed ID: 32168879	2020
Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages. Microorganisms\| PubMed ID: 32316261	2020
Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy. Engineering in life sciences\| PubMed ID: 32624804	2017
Rapid Target Binding and Cargo Release of Activatable Liposomes Bearing HER2 and FAP Single-Chain Antibody Fragments Reveal Potentials for Image-Guided Delivery to Tumors. Pharmaceutics\| PubMed ID: 33076292	2020
A versatile and customizable low-cost 3D-printed open standard for microscopic imaging. Nature communications\| PubMed ID: 33239615	2020
In vitro infection models to study fungal-host interactions. FEMS microbiology reviews\| PubMed ID: 33524102	2021
Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis. Cancers\| PubMed ID: 33530588	2021
SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction. Journal of virology\| PubMed ID: 33637603	2021
Emulating the gut-liver axis: Dissecting the microbiome's effect on drug metabolism using multiorgan-on-chip models. Current opinion in endocrine and metabolic research\| PubMed ID: 34239997	2021
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. Journal of medicinal chemistry\| PubMed ID: 34279935	2021
The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2. Oncogene\| PubMed ID: 35513564	2022
Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model. Biomaterials\| PubMed ID: 35728409	2022
Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections. Open biology\| PubMed ID: 36977462	2023
Asymmetric Block Extension of Star-Shaped [PEG-SH] - toward Poly(dehydroalanine)-Functionalized PEG Hydrogels for Catch and Release of Charged Guest Molecules. Macromolecular bioscience\| PubMed ID: 37572335	2024
Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. Scientific reports\| PubMed ID: 37587168	2023
Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model. BMC research notes\| PubMed ID: 37865791	2023
Self-Degrading Multifunctional PEG-Based Hydrogels-Tailormade Substrates for Cell Culture. Macromolecular bioscience\| PubMed ID: 38102978	2024
An Organ-on-Chip Platform for Simulating Drug Metabolism Along the Gut-Liver Axis. Advanced healthcare materials\| PubMed ID: 38452399	2024
Tailoring the Degradation Time of Polycationic PEG-Based Hydrogels toward Dynamic Cell Culture Matrices. ACS applied bio materials\| PubMed ID: 38470448	2024
Quantification of Polystyrene Uptake by Different Cell Lines Using Fluorescence Microscopy and Label-Free Visualization of Intracellular Polystyrene Particles by Raman Microspectroscopic Ima... Cells\| PubMed ID: 38474417	2024
Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity. Biomaterials\| PubMed ID: 38489910	2024
Organ-on-chip models for infectious disease research. Nature microbiology\| PubMed ID: 38528150	2024
Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response. Communications biology\| PubMed ID: 38755249	2024