Alexander S. Mosig

A microfluidically perfused three dimensional human liver model.

A human macrophage-hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica.

Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model.

Recruitment of CD16(+) monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine.

An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development.

Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery.

High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure.

Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase.

Organ-on-chip models: new opportunities for biomedical research.

Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer.

Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency.

Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage.

Functional Analyses of RUNX3 and CaMKIINα in Ovarian Cancer Cell Lines Reveal Tumor-Suppressive Functions for CaMKIINα and Dichotomous Roles for RUNX3 Transcript Variants.

Microphysiological systems meet hiPSC technology - New tools for disease modeling of liver infections in basic research and drug development.

β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages.

CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an Liver-on-Chip Model.

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies.

Keeping commensal: how lactobacilli antagonize pathogenicity of in an gut model.

The Peroxisome Proliferator-Activated Receptor (PPAR)- Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPAR and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages.

Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model.

VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1.

Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages.

Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy.

Rapid Target Binding and Cargo Release of Activatable Liposomes Bearing HER2 and FAP Single-Chain Antibody Fragments Reveal Potentials for Image-Guided Delivery to Tumors.

A versatile and customizable low-cost 3D-printed open standard for microscopic imaging.

In vitro infection models to study fungal-host interactions.

Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis.

SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction.

Emulating the gut-liver axis: Dissecting the microbiome's effect on drug metabolism using multiorgan-on-chip models.

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.

The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2.

Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model.

Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections.

Asymmetric Block Extension of Star-Shaped [PEG-SH] - toward Poly(dehydroalanine)-Functionalized PEG Hydrogels for Catch and Release of Charged Guest Molecules.

Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model.

Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model.

Self-Degrading Multifunctional PEG-Based Hydrogels-Tailormade Substrates for Cell Culture.

An Organ-on-Chip Platform for Simulating Drug Metabolism Along the Gut-Liver Axis.

Tailoring the Degradation Time of Polycationic PEG-Based Hydrogels toward Dynamic Cell Culture Matrices.

Quantification of Polystyrene Uptake by Different Cell Lines Using Fluorescence Microscopy and Label-Free Visualization of Intracellular Polystyrene Particles by Raman Microspectroscopic Imaging.

Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity.

Organ-on-chip models for infectious disease research.

Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response.