First Affiliated Hospital to Changchun University of Chinese Medicine

2 ARTICLES PUBLISHED IN JoVE

Biochemistry

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Juanjuan Shen¹, Chunjie Hu², Yuan Li¹, Xiaoling Shang¹, Yue Deng², Jiajuan Guo², Lina Zhang¹, Jinfeng Wang¹, Wenfeng Zhang¹

¹Changchun University of Chinese Medicine, ²First Affiliated Hospital to Changchun University of Chinese Medicine

Here, we present a protocol to induce H-type hypertension and evaluate the antihypertensive effects of Huotan Jiedu Tongluo decoction (HTJDTLD) administered intragastrically. In rats with H-type hypertension, HTJDTLD had effective antihypertensive effects, possibly associated with inhibition of endoplasmic reticulum (ER) stress-induced apoptosis pathway activation.

Medicine

Construction of Lung Adenocarcinoma Xenograft Model in Mice and Evaluation of the Efficiency of XY Decoction through MAPK Pathway

Yuhan Wang¹, Tan Wang², Ziyuan Wang², Keju Wang², Dongcai Wu¹, Siyu Song^3,4,5, Mengzhu Chen²

¹College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, ²Respiratory Department, First Affiliated Hospital to Changchun University of Chinese Medicine, ³Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Changchun University of Chinese Medicine, ⁴Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Ministry of Education, Changchun University of Chinese Medicine, ⁵Northeast Asia Research Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine

This study demonstrates that XY decoction exerts therapeutic effects against lung adenocarcinoma by regulating the MAPK pathway.