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First Affiliated Hospital to Changchun University of Chinese Medicine

1 ARTICLES PUBLISHED IN JoVE

Biochemistry

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Juanjuan Shen¹, Chunjie Hu², Yuan Li¹, Xiaoling Shang¹, Yue Deng², Jiajuan Guo², Lina Zhang¹, Jinfeng Wang¹, Wenfeng Zhang¹

¹Changchun University of Chinese Medicine, ²First Affiliated Hospital to Changchun University of Chinese Medicine

Here, we present a protocol to induce H-type hypertension and evaluate the antihypertensive effects of Huotan Jiedu Tongluo decoction (HTJDTLD) administered intragastrically. In rats with H-type hypertension, HTJDTLD had effective antihypertensive effects, possibly associated with inhibition of endoplasmic reticulum (ER) stress-induced apoptosis pathway activation.