Irving C. Allen

Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University

Affiliated withVirginia Polytechnic Institute and State University Virginia Maryland College of Veterinary Medicine, Virginia Tech Virginia Tech

Research Area

Immunology and InfectionCancer ResearchMedicine

Biography

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JoVE Journal Publications

Article Total : 4	Year
Publication title	2014
Publication title	2016
Publication title	2020
Publication title	2019

Other Publications

Article	Year
Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16243899	2006
Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16829631	2006
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity\| PubMed ID: 19362020	2009
Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19494266	2009
NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19587006	2009
Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PloS one\| PubMed ID: 19826485	2009
Searching for an improved mouse model of allergic airway disease using dual allergen exposures. Disease models & mechanisms\| PubMed ID: 19892879	2009
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. The Journal of experimental medicine\| PubMed ID: 20385749	2010
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PloS one\| PubMed ID: 20808838	2010
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20861349	2010
The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells. Cancer research\| PubMed ID: 21159638	2010
The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. The Journal of biological chemistry\| PubMed ID: 21487011	2011
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity\| PubMed ID: 21703540	2011
Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21984570	2012
A NOD to zebrafish models of inflammatory bowel disease pathogenesis. Disease models & mechanisms\| PubMed ID: 22065838	2011
Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome. The Journal of infectious diseases\| PubMed ID: 22279123	2012
Characterization of NLRP12 during the development of allergic airway disease in mice. PloS one\| PubMed ID: 22291998	2012
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PloS one\| PubMed ID: 22295065	2012
Analysis of NLRP3 in the development of allergic airway disease in mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22323538	2012
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity\| PubMed ID: 22503542	2012
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nature immunology\| PubMed ID: 22863753	2012
Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production. PloS one\| PubMed ID: 22916243	2012
Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis. PloS one\| PubMed ID: 23577168	2013
Analysis of the murine immune response to pulmonary delivery of precisely fabricated nano- and microscale particles. PloS one\| PubMed ID: 23593509	2013
Primary ear fibroblast derivation from mice. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23824888	2013
Delayed-type hypersensitivity models in mice. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23824893	2013
Bacteria-mediated acute lung inflammation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23824899	2013
Contact hypersensitivity models in mice. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23943450	2013
Induction of allergic airway disease using house dust mite allergen. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23943452	2013
Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO reports\| PubMed ID: 24008845	2013
Correction: Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis. PloS one\| PubMed ID: 24223688	2013