Charles C. Richardson

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Research Area

BiologyGeneticsUnit 1

Biography

Charles C. Richardson has not added Biography.
If you are Charles C. Richardson and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

Article Total : 2	Year
Publication title	2010
Publication title	2017

Other Publications

Article	Year
Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins. Journal of molecular biology\| PubMed ID: 11829500	2002
Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12228732	2002
Essential amino acid residues in the single-stranded DNA-binding protein of bacteriophage T7. Identification of the dimer interface. The Journal of biological chemistry\| PubMed ID: 12379653	2002
The DNA binding domain of the gene 2.5 single-stranded DNA-binding protein of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 12496273	2003
A covalent linkage between the gene 5 DNA polymerase of bacteriophage T7 and Escherichia coli thioredoxin, the processivity factor: fate of thioredoxin during DNA synthesis. The Journal of biological chemistry\| PubMed ID: 12692131	2003
A single-stranded DNA-binding protein of bacteriophage T7 defective in DNA annealing. The Journal of biological chemistry\| PubMed ID: 12748198	2003
The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase. The Journal of biological chemistry\| PubMed ID: 12766155	2003
Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. Molecular cell\| PubMed ID: 12769857	2003
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (New York, N.Y.)\| PubMed ID: 12947199	2003
Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15004283	2004
Effect of single-stranded DNA-binding proteins on the helicase and primase activities of the bacteriophage T7 gene 4 protein. The Journal of biological chemistry\| PubMed ID: 15044449	2004
The linker region between the helicase and primase domains of the gene 4 protein of bacteriophage T7. Role in helicase conformation and activity. The Journal of biological chemistry\| PubMed ID: 15044475	2004
The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15070725	2004
A unique region in bacteriophage t7 DNA polymerase important for exonucleolytic hydrolysis of DNA. The Journal of biological chemistry\| PubMed ID: 15292168	2004
The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini. The Journal of biological chemistry\| PubMed ID: 15377656	2004
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15528277	2004
A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15795374	2005
Acidic residues in the nucleotide-binding site of the bacteriophage T7 DNA primase. The Journal of biological chemistry\| PubMed ID: 15917241	2005
DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicase. Molecular cell\| PubMed ID: 16427007	2006
DNA primase acts as a molecular brake in DNA replication. Nature\| PubMed ID: 16452983	2006
Primer initiation and extension by T7 DNA primase. The EMBO journal\| PubMed ID: 16642036	2006
Oligomeric states of bacteriophage T7 gene 4 primase/helicase. Journal of molecular biology\| PubMed ID: 16777142	2006
The C-terminal residues of bacteriophage T7 gene 4 helicase-primase coordinate helicase and DNA polymerase activities. The Journal of biological chemistry\| PubMed ID: 16807231	2006
Essential residues in the C terminus of the bacteriophage T7 gene 2.5 single-stranded DNA-binding protein. The Journal of biological chemistry\| PubMed ID: 16807232	2006
Single molecule force spectroscopy of salt-dependent bacteriophage T7 gene 2.5 protein binding to single-stranded DNA. The Journal of biological chemistry\| PubMed ID: 17050544	2006
Genomewide screens for Escherichia coli genes affecting growth of T7 bacteriophage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17135349	2006
Exchange of DNA polymerases at the replication fork of bacteriophage T7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17369350	2007
Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. Molecular cell\| PubMed ID: 17707227	2007
Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk. Molecular microbiology\| PubMed ID: 18067538	2008
Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18238893	2008
Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18574147	2008
Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18599435	2008
Peptide ligands specific to the oxidized form of Escherichia coli thioredoxin. Biochimica et biophysica acta\| PubMed ID: 18672101	2008
Interactions of Escherichia coli thioredoxin, the processivity factor, with bacteriophage T7 DNA polymerase and helicase. The Journal of biological chemistry\| PubMed ID: 18757858	2008
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis. Nature\| PubMed ID: 19029884	2009
DNA recognition by the DNA primase of bacteriophage T7: a structure-function study of the zinc-binding domain. Biochemistry\| PubMed ID: 19206208	2009
Promiscuous usage of nucleotides by the DNA helicase of bacteriophage T7: determinants of nucleotide specificity. The Journal of biological chemistry\| PubMed ID: 19297330	2009
Motors, switches, and contacts in the replisome. Annual review of biochemistry\| PubMed ID: 19298182	2009
Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C-terminal phenylalanine. Molecular microbiology\| PubMed ID: 19400798	2009
Rescue of bacteriophage T7 DNA polymerase of low processivity by suppressor mutations affecting gene 3 endonuclease. Journal of virology\| PubMed ID: 19535436	2009
An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities. The Journal of biological chemistry\| PubMed ID: 19574219	2009
C-terminal phenylalanine of bacteriophage T7 single-stranded DNA-binding protein is essential for strand displacement synthesis by T7 DNA polymerase at a nick in DNA. The Journal of biological chemistry\| PubMed ID: 19726688	2009
Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080681	2010
Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7. Nucleic acids research\| PubMed ID: 20350931	2010
Residues in the central beta-hairpin of the DNA helicase of bacteriophage T7 are important in DNA unwinding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20351255	2010
Two modes of interaction of the single-stranded DNA-binding protein of bacteriophage T7 with the DNA polymerase-thioredoxin complex. The Journal of biological chemistry\| PubMed ID: 20375019	2010
Direct role for the RNA polymerase domain of T7 primase in primer delivery. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20439755	2010
A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7. Molecular microbiology\| PubMed ID: 20497505	2010
Molecular basis for recognition of nucleoside triphosphate by gene 4 helicase of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 20688917	2010
Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20696935	2010
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21245349	2011
The glutamate switch of bacteriophage T7 DNA helicase: role in coupling nucleotide triphosphate (NTP) and DNA binding to NTP hydrolysis. The Journal of biological chemistry\| PubMed ID: 21566126	2011
Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21606333	2011
Pyrovanadolysis, a pyrophosphorolysis-like reaction mediated by pyrovanadate, Mn2+, and DNA polymerase of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 21697085	2011
Bypass of a nick by the replisome of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 21701044	2011
Coupling dTTP hydrolysis with DNA unwinding by the DNA helicase of bacteriophage T7. The Journal of biological chemistry\| PubMed ID: 21840995	2011
Choreography of bacteriophage T7 DNA replication. Current opinion in chemical biology\| PubMed ID: 21907611	2011
Essential protein interactions within the replisome regulate DNA replication. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22067709	2011