Department of Biological Chemistry and Molecular Pharmacology
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Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins.
Journal of molecular biology Feb, 2002 | Pubmed ID: 11829500
Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2002 | Pubmed ID: 12228732
Essential amino acid residues in the single-stranded DNA-binding protein of bacteriophage T7. Identification of the dimer interface.
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12379653
The DNA binding domain of the gene 2.5 single-stranded DNA-binding protein of bacteriophage T7.
The Journal of biological chemistry Feb, 2003 | Pubmed ID: 12496273
A covalent linkage between the gene 5 DNA polymerase of bacteriophage T7 and Escherichia coli thioredoxin, the processivity factor: fate of thioredoxin during DNA synthesis.
The Journal of biological chemistry Jun, 2003 | Pubmed ID: 12692131
A single-stranded DNA-binding protein of bacteriophage T7 defective in DNA annealing.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12748198
The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12766155
Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis.
Molecular cell May, 2003 | Pubmed ID: 12769857
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder.
Science (New York, N.Y.) Aug, 2003 | Pubmed ID: 12947199
Proteomic analysis of thioredoxin-targeted proteins in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 15004283
Effect of single-stranded DNA-binding proteins on the helicase and primase activities of the bacteriophage T7 gene 4 protein.
The Journal of biological chemistry May, 2004 | Pubmed ID: 15044449
The linker region between the helicase and primase domains of the gene 4 protein of bacteriophage T7. Role in helicase conformation and activity.
The Journal of biological chemistry May, 2004 | Pubmed ID: 15044475
The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2004 | Pubmed ID: 15070725
A unique region in bacteriophage t7 DNA polymerase important for exonucleolytic hydrolysis of DNA.
The Journal of biological chemistry Oct, 2004 | Pubmed ID: 15292168
The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini.
The Journal of biological chemistry Nov, 2004 | Pubmed ID: 15377656
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2004 | Pubmed ID: 15528277
A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2005 | Pubmed ID: 15795374
Acidic residues in the nucleotide-binding site of the bacteriophage T7 DNA primase.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15917241
DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicase.
Molecular cell Jan, 2006 | Pubmed ID: 16427007
DNA primase acts as a molecular brake in DNA replication.
Nature Feb, 2006 | Pubmed ID: 16452983
Primer initiation and extension by T7 DNA primase.
The EMBO journal May, 2006 | Pubmed ID: 16642036
Oligomeric states of bacteriophage T7 gene 4 primase/helicase.
Journal of molecular biology Jul, 2006 | Pubmed ID: 16777142
The C-terminal residues of bacteriophage T7 gene 4 helicase-primase coordinate helicase and DNA polymerase activities.
The Journal of biological chemistry Sep, 2006 | Pubmed ID: 16807231
Essential residues in the C terminus of the bacteriophage T7 gene 2.5 single-stranded DNA-binding protein.
The Journal of biological chemistry Sep, 2006 | Pubmed ID: 16807232
Single molecule force spectroscopy of salt-dependent bacteriophage T7 gene 2.5 protein binding to single-stranded DNA.
The Journal of biological chemistry Dec, 2006 | Pubmed ID: 17050544
Genomewide screens for Escherichia coli genes affecting growth of T7 bacteriophage.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2006 | Pubmed ID: 17135349
Exchange of DNA polymerases at the replication fork of bacteriophage T7.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2007 | Pubmed ID: 17369350
Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement.
Molecular cell Aug, 2007 | Pubmed ID: 17707227
Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk.
Molecular microbiology Jan, 2008 | Pubmed ID: 18067538
Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18238893
Communication between subunits critical to DNA binding by hexameric helicase of bacteriophage T7.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18574147
Gene 1.7 of bacteriophage T7 confers sensitivity of phage growth to dideoxythymidine.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18599435
Peptide ligands specific to the oxidized form of Escherichia coli thioredoxin.
Biochimica et biophysica acta Nov, 2008 | Pubmed ID: 18672101
Interactions of Escherichia coli thioredoxin, the processivity factor, with bacteriophage T7 DNA polymerase and helicase.
The Journal of biological chemistry Nov, 2008 | Pubmed ID: 18757858
Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis.
Nature Jan, 2009 | Pubmed ID: 19029884
DNA recognition by the DNA primase of bacteriophage T7: a structure-function study of the zinc-binding domain.
Biochemistry Mar, 2009 | Pubmed ID: 19206208
Promiscuous usage of nucleotides by the DNA helicase of bacteriophage T7: determinants of nucleotide specificity.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19297330
Motors, switches, and contacts in the replisome.
Annual review of biochemistry , 2009 | Pubmed ID: 19298182
Mutations in the gene 5 DNA polymerase of bacteriophage T7 suppress the dominant lethal phenotype of gene 2.5 ssDNA binding protein lacking the C-terminal phenylalanine.
Molecular microbiology May, 2009 | Pubmed ID: 19400798
Rescue of bacteriophage T7 DNA polymerase of low processivity by suppressor mutations affecting gene 3 endonuclease.
Journal of virology Sep, 2009 | Pubmed ID: 19535436
An in trans interaction at the interface of the helicase and primase domains of the hexameric gene 4 protein of bacteriophage T7 modulates their activities.
The Journal of biological chemistry Aug, 2009 | Pubmed ID: 19574219
C-terminal phenylalanine of bacteriophage T7 single-stranded DNA-binding protein is essential for strand displacement synthesis by T7 DNA polymerase at a nick in DNA.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19726688
Thioredoxin suppresses microscopic hopping of T7 DNA polymerase on duplex DNA.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20080681
Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7.
Nucleic acids research Jul, 2010 | Pubmed ID: 20350931
Residues in the central beta-hairpin of the DNA helicase of bacteriophage T7 are important in DNA unwinding.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2010 | Pubmed ID: 20351255
Two modes of interaction of the single-stranded DNA-binding protein of bacteriophage T7 with the DNA polymerase-thioredoxin complex.
The Journal of biological chemistry Jun, 2010 | Pubmed ID: 20375019
Direct role for the RNA polymerase domain of T7 primase in primer delivery.
Proceedings of the National Academy of Sciences of the United States of America May, 2010 | Pubmed ID: 20439755
A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7.
Molecular microbiology Jul, 2010 | Pubmed ID: 20497505
Molecular basis for recognition of nucleoside triphosphate by gene 4 helicase of bacteriophage T7.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20688917
Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20696935
Simultaneous single-molecule measurements of phage T7 replisome composition and function reveal the mechanism of polymerase exchange.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21245349
The glutamate switch of bacteriophage T7 DNA helicase: role in coupling nucleotide triphosphate (NTP) and DNA binding to NTP hydrolysis.
The Journal of biological chemistry Jul, 2011 | Pubmed ID: 21566126
Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2011 | Pubmed ID: 21606333
Pyrovanadolysis, a pyrophosphorolysis-like reaction mediated by pyrovanadate, Mn2+, and DNA polymerase of bacteriophage T7.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21697085
Bypass of a nick by the replisome of bacteriophage T7.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21701044
Coupling dTTP hydrolysis with DNA unwinding by the DNA helicase of bacteriophage T7.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21840995
Choreography of bacteriophage T7 DNA replication.
Current opinion in chemical biology Oct, 2011 | Pubmed ID: 21907611
Essential protein interactions within the replisome regulate DNA replication.
Cell cycle (Georgetown, Tex.) Oct, 2011 | Pubmed ID: 22067709
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