Arturo Zychlinsky

Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2.

Neutrophil elastase targets virulence factors of enterobacteria.

Caspase-1 activation by Salmonella.

The ShiA protein encoded by the Shigella flexneri SHI-2 pathogenicity island attenuates inflammation.

Introduction: Forum in immunology on neutrophils.

Neutrophil extracellular traps kill bacteria.

Toll-like receptors are temporally involved in host defense.

How do neutrophils and pathogens interact?

MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus.

Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself.

Human neutrophils kill Bacillus anthracis.

An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps.

Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms.

ShiA abrogates the innate T-cell response to Shigella flexneri infection.

Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection.

How do microbes evade neutrophil killing?

Novel cell death program leads to neutrophil extracellular traps.

Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps.

What is the role of Toll-like receptors in bacterial infections?

Chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency both yield strongly reduced dihydrorhodamine 123 test signals but can be easily discerned in routine testing for CGD.

Netting bacteria in sepsis.

Beneficial suicide: why neutrophils die to make NETs.

Shigella flexneri phagosomal escape is independent of invasion.

Single residue determines the specificity of neutrophil elastase for Shigella virulence factors.

The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3.

A Toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin.

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.

Fungal and bacterial killing by neutrophils.

IpaB-IpgC interaction defines binding motif for type III secretion translocator.

Restoration of NET formation by gene therapy in CGD controls aspergillosis.

NETs: a new strategy for using old weapons.

Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans.

Sepsis: the dark side of histones.

Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.

Mouse neutrophil extracellular traps in microbial infections.

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease.

Protein refolding is required for assembly of the type three secretion needle.

Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity.

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps.

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.

Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst.

Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy.

Neutrophil Function: From Mechanisms to Disease.