Philip A. Barker

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University

Affiliated withMontreal Neurological Institute, McGill University

Research Area

Neuroscience

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2014

Other Publications

Article	Year
The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease. Journal of neuroscience research\| PubMed ID: 11891783	2002
Retrograde signaling by the neurotrophins follows a well-worn trk. Trends in neurosciences\| PubMed ID: 12127743	2002
Neurotrophin signaling through the p75 neurotrophin receptor. Progress in neurobiology\| PubMed ID: 12169297	2002
Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis. Mechanisms of development\| PubMed ID: 12204258	2002
Constitutive nuclear factor-kappa B activity is required for central neuron survival. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12351721	2002
NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway. The Journal of biological chemistry\| PubMed ID: 12376548	2002
K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. The Journal of biological chemistry\| PubMed ID: 12388555	2002
Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14673001	2003
The p75 neurotrophin receptor: multiple interactors and numerous functions. Progress in brain research\| PubMed ID: 14699954	2004
A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14985432	2004
Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15044543	2004
p75NTR is positively promiscuous: novel partners and new insights. Neuron\| PubMed ID: 15157416	2004
TRAF6-dependent NF-kB transcriptional activity during mouse development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15305292	2004
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15470142	2004
Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. Cancer research\| PubMed ID: 15899819	2005
Getting RIP'd Stunts Your Growth. Neuron\| PubMed ID: 15953410	2005
p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation. EMBO reports\| PubMed ID: 16113645	2005
Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism. The Journal of biological chemistry\| PubMed ID: 16123045	2005
AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chemistry & biology\| PubMed ID: 16492569	2006
Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron\| PubMed ID: 16630834	2006
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Human molecular genetics\| PubMed ID: 17067999	2006
High affinity not in the vicinity? Neuron\| PubMed ID: 17196523	2007
Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17287525	2007
Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis. The Journal of biological chemistry\| PubMed ID: 17452332	2007
Something old, something new: BDNF-induced neuron survival requires TRPC channel function. Nature neuroscience\| PubMed ID: 17453053	2007
Atmospheric science. The monsoon's past. Science (New York, N.Y.)\| PubMed ID: 17540892	2007
Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain. Molecular and cellular neurosciences\| PubMed ID: 17904861	2007
Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation. The Journal of biological chemistry\| PubMed ID: 18299325	2008
Soluble adenylyl cyclase is not required for axon guidance to netrin-1. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18400890	2008
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Molecular cell\| PubMed ID: 18570872	2008
Apoptotic sensitivity of murine IAP-deficient cells. The Biochemical journal\| PubMed ID: 18684108	2008
Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Human molecular genetics\| PubMed ID: 18689798	2008
Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Human molecular genetics\| PubMed ID: 18801879	2008
Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury. Molecular and cellular neurosciences\| PubMed ID: 19049877	2009
Whither proBDNF? Nature neuroscience\| PubMed ID: 19172162	2009
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19295158	2009
Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19339612	2009
A p75(NTR) pivoting paradigm propels perspicacity. Neuron\| PubMed ID: 19376060	2009
Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19403821	2009
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity\| PubMed ID: 19464198	2009
TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex. Hippocampus\| PubMed ID: 20082292	2011
ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133718	2010
De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20385823	2010
LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20463223	2010
The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. Journal of cell science\| PubMed ID: 20530577	2010
Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor. Journal of neurochemistry\| PubMed ID: 21105874	2011
Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21411748	2011
Developing a methodology for carbon isotope analysis of lacustrine diatoms. Rapid communications in mass spectrometry : RCM\| PubMed ID: 21594931	2011
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. The Biochemical journal\| PubMed ID: 22332634	2012
ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23365256	2013
Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development. PloS one\| PubMed ID: 23544124	2013
Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis. Molecular and cellular biology\| PubMed ID: 23689134	2013
XIAP regulates caspase activity in degenerating axons. Cell reports\| PubMed ID: 23954782	2013
p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells. The Journal of biological chemistry\| PubMed ID: 24519935	2014
Neurotrophins in the regulation of cellular survival and death. Handbook of experimental pharmacology\| PubMed ID: 24668474	2014
S100B protein activates a RAGE-dependent autocrine loop in astrocytes: Implications for its role in the propagation of reactive gliosis. Journal of neurochemistry\| PubMed ID: 24923428	2014