Philip A. Barker

The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease.

Retrograde signaling by the neurotrophins follows a well-worn trk.

Neurotrophin signaling through the p75 neurotrophin receptor.

Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis.

Constitutive nuclear factor-kappa B activity is required for central neuron survival.

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.

Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad.

The p75 neurotrophin receptor: multiple interactors and numerous functions.

A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice.

Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension.

p75NTR is positively promiscuous: novel partners and new insights.

TRAF6-dependent NF-kB transcriptional activity during mouse development.

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells.

Getting RIP'd Stunts Your Growth.

p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.

Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.

AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.

Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.

The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface.

High affinity not in the vicinity?

Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription.

Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis.

Something old, something new: BDNF-induced neuron survival requires TRPC channel function.

Atmospheric science. The monsoon's past.

Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.

Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation.

Soluble adenylyl cyclase is not required for axon guidance to netrin-1.

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.

Apoptotic sensitivity of murine IAP-deficient cells.

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.

Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury.

Whither proBDNF?

Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward.

Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling.

A p75(NTR) pivoting paradigm propels perspicacity.

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex.

ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.

LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition.

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling.

Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor.

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.

Developing a methodology for carbon isotope analysis of lacustrine diatoms.

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.

ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.

Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development.

Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.

XIAP regulates caspase activity in degenerating axons.

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.

Neurotrophins in the regulation of cellular survival and death.

S100B protein activates a RAGE-dependent autocrine loop in astrocytes: Implications for its role in the propagation of reactive gliosis.