Jens Lykkesfeldt

Department of Veterinary Disease Biology, University of Copenhagen

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2014

Other Publications

Article	Year
Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11854487	2002
Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis. Journal of neuropathology and experimental neurology\| PubMed ID: 12125739	2002
Increased oxidative damage in vitamin C deficiency is accompanied by induction of ascorbic acid recycling capacity in young but not mature guinea pigs. Free radical research\| PubMed ID: 12150544	2002
Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free radical biology & medicine\| PubMed ID: 12446211	2002
Effect of smoking on erythorbic acid pharmacokinetics. The British journal of nutrition\| PubMed ID: 12720586	2003
Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs. Research in veterinary science\| PubMed ID: 12726746	2003
Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo. Free radical biology & medicine\| PubMed ID: 14642391	2003
Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men. The American journal of clinical nutrition\| PubMed ID: 15159234	2004
Pharmacokinetics of amoxicillin after oral administration in recently weaned piglets with experimentally induced Escherichia coli subtype O149:F4 diarrhea. American journal of veterinary research\| PubMed ID: 15281660	2004
Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers. European journal of nutrition\| PubMed ID: 15309445	2004
Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles. The British journal of nutrition\| PubMed ID: 15333149	2004
Vitamin C pharmacokinetics of plain and slow release formulations in smokers. Clinical nutrition (Edinburgh, Scotland)\| PubMed ID: 15380894	2004
Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone. Journal of neurochemistry\| PubMed ID: 15584921	2004
Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia. Pharmacological research : the official journal of the Italian Pharmacological Society\| PubMed ID: 15829430	2005
Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation. Free radical biology & medicine\| PubMed ID: 15855050	2005
Age-dependent change in Vitamin C status: a phenomenon of maturation rather than of ageing. Mechanisms of ageing and development\| PubMed ID: 15992612	2005
Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavorable? Pediatric research\| PubMed ID: 16189208	2005
Pharmacokinetics of amoxicillin administered in drinking water to recently weaned 3- to 4-week-old pigs with diarrhea experimentally induced by Escherichia coli O149:F4. American journal of veterinary research\| PubMed ID: 16579758	2006
Oxidants and antioxidants in disease: oxidative stress in farm animals. Veterinary journal (London, England : 1997)\| PubMed ID: 16914330	2007
Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 17336279	2007
Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle. Free radical biology & medicine\| PubMed ID: 17602951	2007
Oxidative stress and damage in liver, but not in brain, of Fischer 344 rats subjected to dietary iron supplementation with lipid-soluble [(3,5,5-trimethylhexanoyl)ferrocene]. Journal of biochemical and molecular toxicology\| PubMed ID: 17623885	2007
Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 18006947	2007
Utility of melatonin to treat surgical stress after major vascular surgery--a safety study. Journal of pineal research\| PubMed ID: 18205732	2008
Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. The British journal of nutrition\| PubMed ID: 18309548	2007
Does vitamin C deficiency result in impaired brain development in infants? Redox report : communications in free radical research\| PubMed ID: 19161672	2009
Role of marginal vitamin C deficiency in atherogenesis: in vivo models and clinical studies. Basic & clinical pharmacology & toxicology\| PubMed ID: 19489786	2009
Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabe... The American journal of clinical nutrition\| PubMed ID: 19553299	2009
Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs. The American journal of clinical nutrition\| PubMed ID: 19640959	2009
Keeping the intracellular vitamin C at a physiologically relevant level in endothelial cell culture. Analytical biochemistry\| PubMed ID: 19782654	2010
Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. The British journal of nutrition\| PubMed ID: 20003627	2010
Antioxidant supplementation does not alter endurance training adaptation. Medicine and science in sports and exercise\| PubMed ID: 20019626	2010
High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs. The British journal of nutrition\| PubMed ID: 20875184	2011
Measurement of ascorbic acid and dehydroascorbic acid in biological samples. Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.]\| PubMed ID: 20954159	2002
Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 21325105	2011
Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components. Scandinavian journal of clinical and laboratory investigation\| PubMed ID: 21385017	2011
Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells. Toxicology letters\| PubMed ID: 21421028	2011
Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure. Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease\| PubMed ID: 21933843	2011
Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in guinea pigs. Basic & clinical pharmacology & toxicology\| PubMed ID: 22008605	2012
Role of vitamin C and E supplementation on IL-6 in response to training. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22207723	2012
Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs. Basic & clinical pharmacology & toxicology\| PubMed ID: 22212866	2012
Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used. Nutrition research (New York, N.Y.)\| PubMed ID: 22260866	2012
Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial. Surgical laparoscopy, endoscopy & percutaneous techniques\| PubMed ID: 22678316	2012
Authors' perspective: What is the optimum intake of vitamin C in humans? Critical reviews in food science and nutrition\| PubMed ID: 22698272	2012
Ascorbate status modulates reticuloendothelial iron stores and response to deferasirox iron chelation in ascorbate-deficient rats. Experimental hematology\| PubMed ID: 22713799	2012
Kinetics of acid-induced degradation of tetra- and dihydrobiopterin in relation to their relevance as biomarkers of endothelial function. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals\| PubMed ID: 23066920	2013
Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. PloS one\| PubMed ID: 23119033	2012
Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. Psychiatry research\| PubMed ID: 23465294	2013
Nephrectomized and hepatectomized animal models as tools in preclinical pharmacokinetics. Basic & clinical pharmacology & toxicology\| PubMed ID: 23586405	2013
Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs. The British journal of nutrition\| PubMed ID: 23591139	2013
Does vitamin C deficiency increase lifestyle-associated vascular disease progression? Evidence based on experimental and clinical studies. Antioxidants & redox signaling\| PubMed ID: 23642093	2013
Translational aspects of rectal evoked potentials: a comparative study in rats and humans. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 23703652	2013
Differential toxicological response to positively and negatively charged nanoparticles in the rat brain. Nanotoxicology\| PubMed ID: 23889261	2014
Regulation of vitamin C homeostasis during deficiency. Nutrients\| PubMed ID: 23892714	2013
Whey protein reduces early life weight gain in mice fed a high-fat diet. PloS one\| PubMed ID: 23940754	2013
Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin. Chronobiology international\| PubMed ID: 23998285	2013
Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo. Nutrition research (New York, N.Y.)\| PubMed ID: 24074744	2013
Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model. Journal of critical care\| PubMed ID: 24140166	2014
Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 24333161	2014
Vitamin C. Advances in nutrition (Bethesda, Md.)\| PubMed ID: 24425716	2014
Pronounced inflammatory response to endotoxaemia during nighttime: a randomised cross-over trial. PloS one\| PubMed ID: 24475284	2014
Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains. Redox biology\| PubMed ID: 24563854	2014
Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs. Pflugers Archiv : European journal of physiology\| PubMed ID: 24590510	2014
High-fat feeding increases hepatic vitamin C synthesis and its circulatory mobilization in mice. European journal of nutrition\| PubMed ID: 24700376	2014
The kidneys play an important role in the clearance of rFVIIa in rats. Thrombosis research\| PubMed ID: 24731563	2014
Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. Nutrients\| PubMed ID: 24787032	2014
Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. In vivo (Athens, Greece)\| PubMed ID: 24982213	2014
Antioxidant supplementation for lung disease in cystic fibrosis. The Cochrane database of systematic reviews\| PubMed ID: 25102015	2014
In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain. Nutrition research (New York, N.Y.)\| PubMed ID: 25150123	2014
In vivo toxicity of cationic micelles and liposomes. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 25168934	2014
Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation. Basic & clinical pharmacology & toxicology\| PubMed ID: 25220574	2014
Does Vitamin C Deficiency Affect Cognitive Development and Function? Nutrients\| PubMed ID: 25244370	2014
Positive charge, negative effect: the impact of cationic nanoparticles in the brain. Nanomedicine (London, England)\| PubMed ID: 25253492	2014