Jens Lykkesfeldt

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.

Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis.

Increased oxidative damage in vitamin C deficiency is accompanied by induction of ascorbic acid recycling capacity in young but not mature guinea pigs.

Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation.

Effect of smoking on erythorbic acid pharmacokinetics.

Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs.

Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo.

Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.

Pharmacokinetics of amoxicillin after oral administration in recently weaned piglets with experimentally induced Escherichia coli subtype O149:F4 diarrhea.

Vitamin C supplementation decreases oxidative DNA damage in mononuclear blood cells of smokers.

Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles.

Vitamin C pharmacokinetics of plain and slow release formulations in smokers.

Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone.

Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.

Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation.

Age-dependent change in Vitamin C status: a phenomenon of maturation rather than of ageing.

Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavorable?

Pharmacokinetics of amoxicillin administered in drinking water to recently weaned 3- to 4-week-old pigs with diarrhea experimentally induced by Escherichia coli O149:F4.

Oxidants and antioxidants in disease: oxidative stress in farm animals.

Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking.

Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle.

Oxidative stress and damage in liver, but not in brain, of Fischer 344 rats subjected to dietary iron supplementation with lipid-soluble [(3,5,5-trimethylhexanoyl)ferrocene].

Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization.

Utility of melatonin to treat surgical stress after major vascular surgery--a safety study.

Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain.

Does vitamin C deficiency result in impaired brain development in infants?

Role of marginal vitamin C deficiency in atherogenesis: in vivo models and clinical studies.

Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabetes.

Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs.

Keeping the intracellular vitamin C at a physiologically relevant level in endothelial cell culture.

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials.

Antioxidant supplementation does not alter endurance training adaptation.

High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs.

Measurement of ascorbic acid and dehydroascorbic acid in biological samples.

Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training.

Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components.

Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells.

Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure.

Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in guinea pigs.

Role of vitamin C and E supplementation on IL-6 in response to training.

Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs.

Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used.

Oxidative stress response after laparoscopic versus conventional sigmoid resection: a randomized, double-blind clinical trial.

Authors' perspective: What is the optimum intake of vitamin C in humans?

Ascorbate status modulates reticuloendothelial iron stores and response to deferasirox iron chelation in ascorbate-deficient rats.

Kinetics of acid-induced degradation of tetra- and dihydrobiopterin in relation to their relevance as biomarkers of endothelial function.

Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs.

Increased systemic oxidatively generated DNA and RNA damage in schizophrenia.

Nephrectomized and hepatectomized animal models as tools in preclinical pharmacokinetics.

Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs.

Does vitamin C deficiency increase lifestyle-associated vascular disease progression? Evidence based on experimental and clinical studies.

Translational aspects of rectal evoked potentials: a comparative study in rats and humans.

Differential toxicological response to positively and negatively charged nanoparticles in the rat brain.

Regulation of vitamin C homeostasis during deficiency.

Whey protein reduces early life weight gain in mice fed a high-fat diet.

Circadian variation in the response to experimental endotoxemia and modulatory effects of exogenous melatonin.

Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo.

Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model.

Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies.

Vitamin C.

Pronounced inflammatory response to endotoxaemia during nighttime: a randomised cross-over trial.

Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains.

Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs.

High-fat feeding increases hepatic vitamin C synthesis and its circulatory mobilization in mice.

The kidneys play an important role in the clearance of rFVIIa in rats.

Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression.

Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.

Antioxidant supplementation for lung disease in cystic fibrosis.

In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain.

In vivo toxicity of cationic micelles and liposomes.

Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation.

Does Vitamin C Deficiency Affect Cognitive Development and Function?

Positive charge, negative effect: the impact of cationic nanoparticles in the brain.