Aubin Penna

The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth.

[The TRP family of channels: a complex gallery of characters].

Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors.

PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane.

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria.

Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate.

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.

Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.