Hany Goubran-Botros

Immunoregulatory properties of mast cell-derived exosomes.

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo.

Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders.

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders.

Analysis of X chromosome inactivation in autism spectrum disorders.

An investigation of ribosomal protein L10 gene in autism spectrum disorders.

Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.

Production of soluble, active acetyl serotonin methyl transferase in Leishmania tarentolae.

Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability.

Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland.

Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.

Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.

Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.

A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability.