Department of Pharmaceutical Sciences
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Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes.
Cancer chemotherapy and pharmacology Mar, 2002 | Pubmed ID: 11935214
Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12042310
Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending.
Journal of the American Chemical Society Jul, 2002 | Pubmed ID: 12121096
Thermodynamic and hydration effects for the incorporation of a cationic 3-aminopropyl chain into DNA.
Nucleic acids research Jul, 2002 | Pubmed ID: 12136099
Bites of venomous snakes.
The New England journal of medicine Aug, 2002 | Pubmed ID: 12151473
Effect of cationic charge localization on DNA structure.
Biopolymers Nov, 2002 | Pubmed ID: 12228922
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.
Molecular pharmacology Jan, 2003 | Pubmed ID: 12488552
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes.
DNA repair Aug, 2002 | Pubmed ID: 12509290
Design of triple helix forming C-glycoside molecules.
Journal of the American Chemical Society Feb, 2003 | Pubmed ID: 12590536
Resolution of compartment syndrome after rattlesnake envenomation utilizing non-invasive measures.
The Journal of emergency medicine Apr, 2003 | Pubmed ID: 12676299
Evidence in Escherichia coli that N3-methyladenine lesions and cytotoxicity induced by a minor groove binding methyl sulfonate ester can be modulated in vivo by netropsin.
Biochemistry Nov, 2003 | Pubmed ID: 14580207
DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters.
Biochemistry Dec, 2003 | Pubmed ID: 14640700
The biological effects of N3-methyladenine.
Journal of cellular biochemistry Feb, 2004 | Pubmed ID: 14743385
Triple helix forming TRIPside molecules that target mixed purine/pyrimidine DNA sequences.
Biochemistry Feb, 2004 | Pubmed ID: 14769020
Refractory thrombocytopenia despite treatment for rattlesnake envenomation.
The New England journal of medicine Apr, 2004 | Pubmed ID: 15115843
Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair.
Biochemistry May, 2004 | Pubmed ID: 15134433
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.
DNA repair Jun, 2004 | Pubmed ID: 15135730
North American snake envenomation: diagnosis, treatment, and management.
Emergency medicine clinics of North America May, 2004 | Pubmed ID: 15163575
Ecology. Ecology for a crowded planet.
Science (New York, N.Y.) May, 2004 | Pubmed ID: 15166349
N3-methyladenine induces early poly(ADP-ribosylation), reduction of nuclear factor-kappa B DNA binding ability, and nuclear up-regulation of telomerase activity.
Molecular pharmacology Feb, 2005 | Pubmed ID: 15548765
Structure of B-DNA with cations tethered in the major groove.
Biochemistry May, 2005 | Pubmed ID: 15895989
Molecular recognition via triplex formation of mixed purine/pyrimidine DNA sequences using oligoTRIPs.
Journal of the American Chemical Society Sep, 2005 | Pubmed ID: 16144414
Incorporation of cationic chains in the Dickerson-Drew dodecamer: correlation of energetics, structure, and ion and water binding.
Biochemistry Sep, 2005 | Pubmed ID: 16156670
Synthesis of C-nucleosides designed to participate in triplex formation with native DNA: specific recognition of an A:T base pair in DNA.
The Journal of organic chemistry Oct, 2005 | Pubmed ID: 16238307
Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide.
European journal of cancer (Oxford, England : 1990) Dec, 2005 | Pubmed ID: 16288862
The effect of 3-methyladenine DNA glycosylase-mediated DNA repair on the induction of toxicity and diabetes by the beta-cell toxicant streptozotocin.
Toxicological sciences : an official journal of the Society of Toxicology Feb, 2007 | Pubmed ID: 17098815
A review of the role of the sequence-dependent electrostatic landscape in DNA alkylation patterns.
Chemical research in toxicology Nov, 2006 | Pubmed ID: 17112226
Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2007 | Pubmed ID: 17255284
A study of 7-deaza-2'-deoxyguanosine 2'-deoxycytidine base pairing in DNA.
Nucleic acids research , 2007 | Pubmed ID: 17855404
Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.
DNA repair Mar, 2008 | Pubmed ID: 18182332
A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.
Biochemistry Jul, 2008 | Pubmed ID: 18549246
Enhancing the engagement of U.S. private foundations with conservation science.
Conservation biology : the journal of the Society for Conservation Biology Dec, 2008 | Pubmed ID: 18847442
A facile synthetic approach to 7-deazaguanine nucleosides via a Boc protection strategy.
Organic letters Jun, 2009 | Pubmed ID: 19422208
Introduction of cationic charge into DNA near the major groove edge of a guanine x cytosine base pair: characterization of oligodeoxynucleotides substituted with 7-aminomethyl-7-deaza-2'-deoxyguanosine.
Journal of the American Chemical Society Sep, 2009 | Pubmed ID: 19663509
High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.
Mutation research Dec, 2009 | Pubmed ID: 19729030
Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.
Mutation research Jan, 2010 | Pubmed ID: 19874831
Thermodynamic characterization of DNA with 3-deazaadenine and 3-methyl-3-deazaadenine substitutions: the effect of placing a hydrophobic group in the minor groove of DNA.
The journal of physical chemistry. B Jun, 2010 | Pubmed ID: 20469878
XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine.
DNA repair Jul, 2010 | Pubmed ID: 20471330
Methadone-induced torsade de pointes.
The American journal of emergency medicine May, 2011 | Pubmed ID: 20674223
An unprecedented nucleic acid capture mechanism for excision of DNA damage.
Nature Nov, 2010 | Pubmed ID: 20927102
Effect of n3-methyladenine and an isosteric stable analogue on DNA polymerization.
Journal of nucleic acids , 2010 | Pubmed ID: 20936169
Characterization of DNA with an 8-oxoguanine modification.
Nucleic acids research Aug, 2011 | Pubmed ID: 21572101
3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.
DNA repair Aug, 2011 | Pubmed ID: 21676659
Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA.
The journal of physical chemistry. B Dec, 2011 | Pubmed ID: 22059929
Thermodynamic signature of DNA damage: characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine base pair.
Biochemistry Mar, 2012 | Pubmed ID: 22332945
Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.
Future medicinal chemistry Jun, 2012 | Pubmed ID: 22709253
Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors.
Biochemistry Jul, 2012 | Pubmed ID: 22788932
Synthesis and characterization of DNA minor groove binding alkylating agents.
Chemical research in toxicology Jan, 2013 | Pubmed ID: 23234400
Drug resistance: the problem that keeps on giving.
Future medicinal chemistry Jun, 2013 | Pubmed ID: 23734679
Forward: combating resistance: infectious diseases.
Future medicinal chemistry Jul, 2013 | Pubmed ID: 23859196
Site-specific stabilization of DNA by a tethered major groove amine, 7-aminomethyl-7-deaza-2'-deoxyguanosine.
Biochemistry Oct, 2013 | Pubmed ID: 24131376
Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.
Mutation research Jan, 2014 | Pubmed ID: 24211855
Looking for Waldo: a potential thermodynamic signature to DNA damage.
Accounts of chemical research Apr, 2014 | Pubmed ID: 24702131
T-cells enhance stem cell mutagenesis in the mouse colon.
Mutation research Apr, 2015 | Pubmed ID: 25770826
Design and activity of AP endonuclease-1 inhibitors.
Journal of chemical biology Jul, 2015 | Pubmed ID: 26101550
Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate.
Molecular carcinogenesis Jul, 2015 | Pubmed ID: 26153082
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