Barry Gold

Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes.

Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent.

Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending.

Thermodynamic and hydration effects for the incorporation of a cationic 3-aminopropyl chain into DNA.

Bites of venomous snakes.

Effect of cationic charge localization on DNA structure.

Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.

Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes.

Design of triple helix forming C-glycoside molecules.

Resolution of compartment syndrome after rattlesnake envenomation utilizing non-invasive measures.

Evidence in Escherichia coli that N3-methyladenine lesions and cytotoxicity induced by a minor groove binding methyl sulfonate ester can be modulated in vivo by netropsin.

DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters.

The biological effects of N3-methyladenine.

Triple helix forming TRIPside molecules that target mixed purine/pyrimidine DNA sequences.

Refractory thrombocytopenia despite treatment for rattlesnake envenomation.

Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair.

The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.

North American snake envenomation: diagnosis, treatment, and management.

Ecology. Ecology for a crowded planet.

N3-methyladenine induces early poly(ADP-ribosylation), reduction of nuclear factor-kappa B DNA binding ability, and nuclear up-regulation of telomerase activity.

Structure of B-DNA with cations tethered in the major groove.

Molecular recognition via triplex formation of mixed purine/pyrimidine DNA sequences using oligoTRIPs.

Incorporation of cationic chains in the Dickerson-Drew dodecamer: correlation of energetics, structure, and ion and water binding.

Synthesis of C-nucleosides designed to participate in triplex formation with native DNA: specific recognition of an A:T base pair in DNA.

Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide.

The effect of 3-methyladenine DNA glycosylase-mediated DNA repair on the induction of toxicity and diabetes by the beta-cell toxicant streptozotocin.

A review of the role of the sequence-dependent electrostatic landscape in DNA alkylation patterns.

Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin.

A study of 7-deaza-2'-deoxyguanosine 2'-deoxycytidine base pairing in DNA.

Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.

A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.

Enhancing the engagement of U.S. private foundations with conservation science.

A facile synthetic approach to 7-deazaguanine nucleosides via a Boc protection strategy.

Introduction of cationic charge into DNA near the major groove edge of a guanine x cytosine base pair: characterization of oligodeoxynucleotides substituted with 7-aminomethyl-7-deaza-2'-deoxyguanosine.

High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.

Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.

Thermodynamic characterization of DNA with 3-deazaadenine and 3-methyl-3-deazaadenine substitutions: the effect of placing a hydrophobic group in the minor groove of DNA.

XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine.

Methadone-induced torsade de pointes.

An unprecedented nucleic acid capture mechanism for excision of DNA damage.

Effect of n3-methyladenine and an isosteric stable analogue on DNA polymerization.

Characterization of DNA with an 8-oxoguanine modification.

3-Methyl-3-deazaadenine, a stable isostere of N3-methyl-adenine, is efficiently bypassed by replication in vivo and by transcription in vitro.

Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA.

Thermodynamic signature of DNA damage: characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine base pair.

Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.

Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors.

Synthesis and characterization of DNA minor groove binding alkylating agents.

Drug resistance: the problem that keeps on giving.

Forward: combating resistance: infectious diseases.

Site-specific stabilization of DNA by a tethered major groove amine, 7-aminomethyl-7-deaza-2'-deoxyguanosine.

Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.

Looking for Waldo: a potential thermodynamic signature to DNA damage.

T-cells enhance stem cell mutagenesis in the mouse colon.

Design and activity of AP endonuclease-1 inhibitors.

Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate.