Kenneth J. Pienta

Department of Urology, Johns Hopkins University

Affiliated withJohns Hopkins University Johns Hopkins Medical Institute Johns Hopkins University School of Medicine

Research Area

Immunology and InfectionMedicineBiologyUnit 1Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title	2016
Publication title	2016
Publication title	2022
Publication title	2019

Other Publications

Article	Year
Circulating fibroblast-like cells in men with metastatic prostate cancer. The Prostate\| PubMed ID: 22718300	2013
Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nature genetics\| PubMed ID: 24185510	2013
A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression. BMC systems biology\| PubMed ID: 24612742	2014
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis. The Journal of biological chemistry\| PubMed ID: 25006249	2014
The presence of androgen receptor elements regulates ZEB1 expression in the absence of androgen receptor. Journal of cellular biochemistry\| PubMed ID: 25160502	2015
Therapy decisions for the symptomatic patient with metastatic castration-resistant prostate cancer. Asian journal of andrology\| PubMed ID: 25865849	2015
OVOL guides the epithelial-hybrid-mesenchymal transition. Oncotarget\| PubMed ID: 25944618	2015
Bone marrow macrophages support prostate cancer growth in bone. Oncotarget\| PubMed ID: 26459393	2015
PSMA-Based Detection of Prostate Cancer Bone Lesions With (18)F-DCFPyL PET/CT: A Sensitive Alternative to (99m)Tc-MDP Bone Scan and Na(18)F PET/CT? Clinical genitourinary cancer\| PubMed ID: 26603549	2016
Development of an Automated and Sensitive Microfluidic Device for Capturing and Characterizing Circulating Tumor Cells (CTCs) from Clinical Blood Samples. PloS one\| PubMed ID: 26808060	2016
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26831077	2016
Disseminated tumor cells and dormancy in prostate cancer metastasis. Current opinion in biotechnology\| PubMed ID: 26900985	2016
A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy. Urology case reports\| PubMed ID: 27175343	2016
A phased strategy to differentiate human CD14+monocytes into classically and alternatively activated macrophages and dendritic cells. BioTechniques\| PubMed ID: 27401672	2016
Technical challenges in the isolation and analysis of circulating tumor cells. Oncotarget\| PubMed ID: 27517159	2016
Prediction of the Pathologic Gleason Score to Inform a Personalized Management Program for Prostate Cancer. European urology\| PubMed ID: 27523594	2017
A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow. Oncotarget\| PubMed ID: 27634877	2016
Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations. Nature reviews. Urology\| PubMed ID: 27725639	2017
Positive Feedback Loops Between Inflammatory, Bone and Cancer Cells During Metastatic Niche Construction. Advances in experimental medicine and biology\| PubMed ID: 27739046	2016
Correlation of PSMA-Targeted F-DCFPyL PET/CT Findings With Immunohistochemical and Genomic Data in a Patient With Metastatic Neuroendocrine Prostate Cancer. Clinical genitourinary cancer\| PubMed ID: 27751686	2017
Circulating tumour cells as biomarkers of prostate, bladder, and kidney cancer. Nature reviews. Urology\| PubMed ID: 27872478	2017
Semiquantitative Parameters in PSMA-Targeted PET Imaging with F-DCFPyL: Variability in Normal-Organ Uptake. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 27932557	2017
Nucleolin Staining May Aid in the Identification of Circulating Prostate Cancer Cells. Clinical genitourinary cancer\| PubMed ID: 28153390	2017
The Tumor Microenvironment at a Turning Point Knowledge Gained Over the Last Decade, and Challenges and Opportunities Ahead: A White Paper from the NCI TME Network. Cancer research\| PubMed ID: 28209610	2017
Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis. Molecular cancer research : MCR\| PubMed ID: 28209759	2017
The Identification of Macrophage-enriched Glycoproteins Using Glycoproteomics. Molecular & cellular proteomics : MCP\| PubMed ID: 28348171	2017
The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion. Molecular oncology\| PubMed ID: 28371345	2017
Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration-Resistant Prostate Cancer Treated With First- and Seco... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 28384066	2017
TWIST1-WDR5- Regulates Chromatin to Facilitate Prostate Cancer Metastasis. Cancer research\| PubMed ID: 28484075	2017
Prostate Cancer Local Recurrence Detected With Both F-Fluciclovine and PSMA-targeted F-DCFPyL PET/CT. Urology\| PubMed ID: 28641974	2017
Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration. BMC cancer\| PubMed ID: 28651527	2017
A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE). BMC cancer\| PubMed ID: 28662647	2017
Uptake of the prostate-specific membrane antigen-targeted PET radiotracer 18F-DCFPyL in elastofibroma dorsi. Nuclear medicine communications\| PubMed ID: 28704341	2017
Defining the clinical utility of PSMA-targeted PET imaging of prostate cancer. BJU international\| PubMed ID: 28719112	2017
Prostate Specific Membrane Antigen Targeted F-DCFPyL Positron Emission Tomography/Computerized Tomography for the Preoperative Staging of High Risk Prostate Cancer: Results of a Prospective,... The Journal of urology\| PubMed ID: 28736318	2018
Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging. European journal of nuclear medicine and molecular imaging\| PubMed ID: 28765998	2017
An Unusual Case of Penile Prostate Cancer Uncovered by Multiparametric MRI and PSMA-Targeted 18F-DCFPyL PET/CT. Clinical nuclear medicine\| PubMed ID: 28806262	2017
Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted F-DCFPyL in peripheral ganglia. Annals of nuclear medicine\| PubMed ID: 28831739	2017
Oligometastatic prostate cancer: shaping the definition with molecular imaging and an improved understanding of tumor biology. Current opinion in urology\| PubMed ID: 28863016	2017
Proposal for a Structured Reporting System for Prostate-Specific Membrane Antigen-Targeted PET Imaging: PSMA-RADS Version 1.0. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 28887401	2018
Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment. Cancer research\| PubMed ID: 28916657	2017
Selection-free method reveals phenotypic diversity among prostate cancer circulating tumour cells. BJU international\| PubMed ID: 29105994	2017
PSMA-RADS Version 1.0: A Step Towards Standardizing the Interpretation and Reporting of PSMA-targeted PET Imaging Studies. European urology\| PubMed ID: 29132714	2018
Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone. The Journal of clinical investigation\| PubMed ID: 29202471	2018
Re: Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer. European urology\| PubMed ID: 29221660	2017
Complete biochemical response after stereotactic ablative radiotherapy of an isolated prostate cancer pelvic soft tissue recurrence detected by 18F-DCFPyL PET/CT. Urology case reports\| PubMed ID: 29226093	2018
Patient-Paired Sample Congruence Between 2 Commercial Liquid Biopsy Tests. JAMA oncology\| PubMed ID: 29242909	2018
Analogous detection of circulating tumor cells using the AccuCyte -CyteFinder system and ISET system in patients with locally advanced and metastatic prostate cancer. The Prostate\| PubMed ID: 29285777	2018
Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells. PloS one\| PubMed ID: 29324844	2018
Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platfo... The Journal of urology\| PubMed ID: 29339080	2018
Characterization of Urothelial Cancer Circulating Tumor Cells with a Novel Selection-Free Method. Urology\| PubMed ID: 29432873	2018
PBOV1 as a potential biomarker for more advanced prostate cancer based on protein and digital histomorphometric analysis. The Prostate\| PubMed ID: 29520928	2018
Diagnosing small bowel carcinoid tumor in a patient with oligometastatic prostate cancer imaged with PSMA-Targeted [F]DCFPyL PET/CT: Value of the PSMA-RADS-3D Designation. Urology case reports\| PubMed ID: 29541580	2018
Symmetry and symmetry breaking in cancer: a foundational approach to the cancer problem. Oncotarget\| PubMed ID: 29545909	2018
SSTR-RADS Version 1.0 as a Reporting System for SSTR PET Imaging and Selection of Potential PRRT Candidates: A Proposed Standardization Framework. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 29572257	2018
A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted F-DCFPyL Positron Emission Tomography Imaging. Urology\| PubMed ID: 29626569	2018
Targeting the tumour stroma to improve cancer therapy. Nature reviews. Clinical oncology\| PubMed ID: 29651130	2018
Meeting report from the Prostate Cancer Foundation PSMA-directed radionuclide scientific working group. The Prostate\| PubMed ID: 29717499	2018
Cancer as a Social Dysfunction-Why Cancer Research Needs New Thinking. Molecular cancer research : MCR\| PubMed ID: 29784670	2018
Compositional differences in gastrointestinal microbiota in prostate cancer patients treated with androgen axis-targeted therapies. Prostate cancer and prostatic diseases\| PubMed ID: 29988102	2018
Optimization of Immunofluorescent Detection of Bone Marrow Disseminated Tumor Cells. Biological procedures online\| PubMed ID: 29988526	2018
Regarding the Congruence Between 2 Circulating Tumor DNA Sequencing Assays-Reply. JAMA oncology\| PubMed ID: 30027215	2018
Molecular imaging reporting and data systems (MI-RADS): a generalizable framework for targeted radiotracers with theranostic implications. Annals of nuclear medicine\| PubMed ID: 30109562	2018
O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. The Journal of clinical investigation\| PubMed ID: 30130254	2018
Follow-up of Lesions with Equivocal Radiotracer Uptake on PSMA-Targeted PET in Patients with Prostate Cancer: Predictive Values of the PSMA-RADS-3A and PSMA-RADS-3B Categories. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 30190303	2019
Interobserver Agreement for the Standardized Reporting System PSMA-RADS 1.0 on F-DCFPyL PET/CT Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 30190304	2018
Stereotactic ablative radiation therapy for oligometastatic prostate cancer delays time-to-next systemic treatment. World journal of urology\| PubMed ID: 30191396	2019
3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification. Scientific reports\| PubMed ID: 30209281	2018
Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas. Clinical nuclear medicine\| PubMed ID: 30247210	2018
Publisher Correction: 3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification. Scientific reports\| PubMed ID: 30367081	2018
Optimization of prostate cancer cell detection using multiplex tyramide signal amplification. Journal of cellular biochemistry\| PubMed ID: 30390333	2019
Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies. Nature reviews. Urology\| PubMed ID: 30479377	2019
PSMA-targeted [F]DCFPyL PET/CT-avid lesions in a patient with prostate cancer: Clinical decision-making informed by the PSMA-RADS interpretive framework. Urology case reports\| PubMed ID: 30705827	2019
Computational Modeling of the Crosstalk Between Macrophage Polarization and Tumor Cell Plasticity in the Tumor Microenvironment. Frontiers in oncology\| PubMed ID: 30729096	2019
Recent advances in extracellular vesicle research for urological cancers: From technology to application. Biochimica et biophysica acta. Reviews on cancer\| PubMed ID: 30738098	2019
Hereditary Spherocytosis Presenting as Diffuse Bone Marrow Activation and Splenomegaly on PSMA-Targeted 18F-DCFPyL PET/CT. Clinical nuclear medicine\| PubMed ID: 30789396	2019
Novel Structured Reporting Systems for Theranostic Radiotracers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 30796171	2019
Imaging and Characterization of Macrophage Distribution in Mouse Models of Human Prostate Cancer. Molecular imaging and biology\| PubMed ID: 30805886	2019
Semiquantitative Parameters in PSMA-Targeted PET Imaging with [F]DCFPyL: Intrapatient and Interpatient Variability of Normal Organ Uptake. Molecular imaging and biology\| PubMed ID: 31115751	2020
Semiquantitative Parameters in PSMA-Targeted PET Imaging with [F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake. Molecular imaging and biology\| PubMed ID: 31140110	2020
Prospective Evaluation of PSMA-Targeted F-DCFPyL PET/CT in Men with Biochemical Failure After Radical Prostatectomy for Prostate Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 31201249	2020
Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer: An Update on Important Pitfalls. Seminars in nuclear medicine\| PubMed ID: 31227049	2019
Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease. European urology oncology\| PubMed ID: 31277779	2019
Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance. The Prostate\| PubMed ID: 31376205	2019
Can the interplay between androgen signaling and PSMA expression be leveraged for theranostic applications? Translational andrology and urology\| PubMed ID: 31392140	2019
Radiation Therapy in the Definitive Management of Oligometastatic Prostate Cancer: The Johns Hopkins Experience. International journal of radiation oncology, biology, physics\| PubMed ID: 31419509	2019
Detection and isolation of disseminated tumor cells in bone marrow of patients with clinically localized prostate cancer. The Prostate\| PubMed ID: 31449673	2019
Prospective Comparison of PET Imaging with PSMA-Targeted F-DCFPyL Versus NaF for Bone Lesion Detection in Patients with Metastatic Prostate Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 31451492	2020
Re: Identification and Characterization of Circulating Tumor Cells in Men Who Have Undergone Prostatectomy of Clinically Localized, High Risk Prostate Cancer. European urology\| PubMed ID: 31477346	2020
Gleason pattern 5 is associated with an increased risk for metastasis following androgen deprivation therapy and radiation: An analysis of RTOG 9202 and 9902. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 31540746	2019
Circulating Tumor Cell and Circulating Tumor DNA Assays Reveal Complementary Information for Patients with Metastatic Urothelial Cancer. European urology oncology\| PubMed ID: 31563523	2021
Letter to the Editor re: "Semiquantitative Parameters in PSMA-Targeted PET Imaging with [F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake". Molecular imaging and biology\| PubMed ID: 31832870	2020
Uptake of prostate-specific membrane antigen-targeted F-DCFPyL in avascular necrosis of the femoral head. World journal of nuclear medicine\| PubMed ID: 31933560	2019
Vas deferens infiltration by prostate cancer on prostate-specific membrane antigen-targeted F-DCFPyL positron emission tomography/computed tomography: A unique visual pattern. World journal of nuclear medicine\| PubMed ID: 31933562	2019
NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma. Journal for immunotherapy of cancer\| PubMed ID: 31940589	2020
CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31964784	2020
The combination of size-based separation and selection-free technology provides higher circulating tumour cells detection sensitivity than either method alone in patients with metastatic pro... BJU international\| PubMed ID: 32115854	2020
Perspectives in Oncology: a new article type for Medical Oncology. Medical oncology (Northwood, London, England)\| PubMed ID: 32146528	2020
Extracellular vesicle isolation from human renal cancer tissue. Medical oncology (Northwood, London, England)\| PubMed ID: 32172294	2020
Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer: The ORIOLE Phase 2 Randomized Clinical Trial. JAMA oncology\| PubMed ID: 32215577	2020
Wnt Signaling Drives Prostate Cancer Bone Metastatic Tropism and Invasion. Translational oncology\| PubMed ID: 32217460	2020
Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer. Molecular cancer research : MCR\| PubMed ID: 32234827	2020
Prostate Specific Antigen and Prostate Specific Antigen Doubling Time Predict Findings on F-DCFPyL Positron Emission Tomography/Computerized Tomography in Patients with Biochemically Recurre... The Journal of urology\| PubMed ID: 32250727	2020
A phase II randomized trial of RAdium-223 dichloride and SABR Versus SABR for oligomEtastatic prostate caNcerS (RAVENS). BMC cancer\| PubMed ID: 32487038	2020
A novel method for detection of exfoliated prostate cancer cells in urine by RNA in situ hybridization. Prostate cancer and prostatic diseases\| PubMed ID: 32820256	2021
Meeting report from the Prostate Cancer Foundation PSMA theranostics state of the science meeting. The Prostate\| PubMed ID: 32865839	2020
Prospective evaluation of Ga-PSMA-11 PET/CT in Chinese men with biochemical recurrence after radical prostatectomy for prostate cancer: relationships between location of recurrence, time aft... Medical oncology (Northwood, London, England)\| PubMed ID: 32920666	2020
Measurement of PET Quantitative Bias In Vivo. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 33037089	2021
CT-based assessment of body composition following neoadjuvant chemohormonal therapy in patients with castration-naïve oligometastatic prostate cancer. The Prostate\| PubMed ID: 33259087	2021
Analysis of the Circulating Tumor Cell Capture Ability of a Slit Filter-Based Method in Comparison to a Selection-Free Method in Multiple Cancer Types. International journal of molecular sciences\| PubMed ID: 33261132	2020
Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy. Seminars in cancer biology\| PubMed ID: 33276091	2020
The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer: The Spectrum Theory Revisited. European urology\| PubMed ID: 33419682	2021
Quantitative and Qualitative Analysis of Blood-based Liquid Biopsies to Inform Clinical Decision-making in Prostate Cancer. European urology\| PubMed ID: 33422353	2021
Detection of Early Progression with F-DCFPyL PET/CT in Men with Metastatic Castration-Resistant Prostate Cancer Receiving Bipolar Androgen Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 33452039	2021
Comprehensive evaluation of methods for small extracellular vesicles separation from human plasma, urine and cell culture medium. Journal of extracellular vesicles\| PubMed ID: 33489012	2020
Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33504594	2021
High-Throughput Simultaneous mRNA Profiling Using nCounter Technology Demonstrates That Extracellular Vesicles Contain Different mRNA Transcripts Than Their Parental Prostate Cancer Cells. Analytical chemistry\| PubMed ID: 33596381	2021
Understanding the tumor-immune microenvironment in prostate cancer. Current opinion in oncology\| PubMed ID: 33606403	2021
Prospective, Single-Arm Trial Evaluating Changes in Uptake Patterns on Prostate-Specific Membrane Antigen-Targeted F-DCFPyL PET/CT in Patients with Castration-Resistant Prostate Cancer Start... Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 33608426	2021
A Phase 2/3 Prospective Multicenter Study of the Diagnostic Accuracy of Prostate Specific Membrane Antigen PET/CT with F-DCFPyL in Prostate Cancer Patients (OSPREY). The Journal of urology\| PubMed ID: 33634707	2021
A Systematic Review and Meta-analysis of the Effectiveness and Toxicities of Lutetium-177-labeled Prostate-specific Membrane Antigen-targeted Radioligand Therapy in Metastatic Castration-Res... European urology\| PubMed ID: 33840558	2021
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single-particle analysis platforms. Journal of extracellular vesicles\| PubMed ID: 33850608	2021
Reply by Authors. The Journal of urology\| PubMed ID: 33853358	2021
Effect of Point-Spread Function Reconstruction for Indeterminate PSMA-RADS-3A Lesions on PSMA-Targeted PET Imaging of Men with Prostate Cancer. Diagnostics (Basel, Switzerland)\| PubMed ID: 33917238	2021
Peripheral androgen blockade in men with castrate-sensitive biochemical recurrent prostate cancer. Medical oncology (Northwood, London, England)\| PubMed ID: 34089393	2021
The European Association of Urology Biochemical Recurrence Risk Groups Predict Findings on PSMA PET in Patients with Biochemically Recurrent Prostate Cancer After Radical Prostatectomy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 34326128	2022
Defining candidate mRNA and protein EV biomarkers to discriminate ccRCC and pRCC from non-malignant renal cells in vitro. Medical oncology (Northwood, London, England)\| PubMed ID: 34331598	2021
The role of liquid biopsies in prostate cancer management. Lab on a chip\| PubMed ID: 34346466	2021
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Cancer research\| PubMed ID: 34645612	2021
Prostate cancer research in the 21st century; report from the 2021 Coffey-Holden prostate cancer academy meeting. The Prostate\| PubMed ID: 34734426	2022
Advancements in the identification of EV derived mRNA biomarkers for liquid biopsy of clear cell renal cell carcinomas. Urology\| PubMed ID: 34793840	2021