Department of Medical Oncology
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Induced formation of a DNA bulge structure by a molecular wedge ligand-postactivated neocarzinostatin chromophore.
Biochemistry Apr, 2002 | Pubmed ID: 11955061
New complex of post-activated neocarzinostatin chromophore with DNA: bulge DNA binding from the minor groove.
Biochemistry Feb, 2003 | Pubmed ID: 12564921
A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.
Journal of the American Chemical Society Mar, 2004 | Pubmed ID: 15025473
Inhibition of colonic aberrant crypt foci by curcumin in rats is affected by age.
Nutrition and cancer , 2004 | Pubmed ID: 15203376
Small molecule transcription factor mimic.
Journal of the American Chemical Society Dec, 2004 | Pubmed ID: 15584709
Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives.
Chemical & pharmaceutical bulletin Feb, 2006 | Pubmed ID: 16462076
Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats.
Nutrition and cancer , 2006 | Pubmed ID: 16800776
Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis.
Scandinavian journal of gastroenterology Jan, 2007 | Pubmed ID: 17190766
Synthesis of new xanthone analogues and their biological activity test--cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study.
Bioorganic & medicinal chemistry letters Mar, 2007 | Pubmed ID: 17194586
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.
Journal of the American Chemical Society Jan, 2007 | Pubmed ID: 17243824
P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis.
Chemistry & biodiversity Jan, 2007 | Pubmed ID: 17256728
Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet.
Phytotherapy research : PTR Jun, 2007 | Pubmed ID: 17335117
Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters Jul, 2007 | Pubmed ID: 17498951
Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex.
Bioorganic & medicinal chemistry letters Nov, 2007 | Pubmed ID: 17827007
Aging alters acute apoptotic response to azoxymethane in the colon of rats.
Experimental gerontology Dec, 2007 | Pubmed ID: 17961945
First synthesis of 4'-selenonucleosides showing unusual Southern conformation.
Organic letters Jan, 2008 | Pubmed ID: 18088134
New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor.
Bioorganic & medicinal chemistry letters Feb, 2008 | Pubmed ID: 18178085
Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner.
Gynecologic oncology Jul, 2008 | Pubmed ID: 18448156
2,2-dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties.
Archives of pharmacal research Sep, 2008 | Pubmed ID: 18806949
A rapid and sensitive screening system for human type I collagen with the aim of discovering potent anti-aging or anti-fibrotic compounds.
Molecules and cells Dec, 2008 | Pubmed ID: 18810249
Age-related differential responses to curcumin-induced apoptosis during the initiation of colon cancer in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Feb, 2009 | Pubmed ID: 19095035
Wrenchnolol derivative optimized for gene activation in cells.
Journal of the American Chemical Society Apr, 2009 | Pubmed ID: 19290630
Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors.
Bioorganic & medicinal chemistry letters May, 2009 | Pubmed ID: 19345580
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.
Journal of medicinal chemistry May, 2009 | Pubmed ID: 19419206
A concise synthesis of licochalcone E and its regio-isomer, licochalcone F.
Chemical & pharmaceutical bulletin Jun, 2009 | Pubmed ID: 19483343
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
Chemistry & biology Aug, 2009 | Pubmed ID: 19716478
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.
Bioorganic & medicinal chemistry Nov, 2009 | Pubmed ID: 19800803
Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors.
Bioorganic & medicinal chemistry letters Dec, 2009 | Pubmed ID: 19836231
2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
Bioorganic & medicinal chemistry Jan, 2010 | Pubmed ID: 19939682
2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.
Bioorganic & medicinal chemistry letters Jan, 2010 | Pubmed ID: 19954977
New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers.
Bioorganic & medicinal chemistry Feb, 2010 | Pubmed ID: 20093033
Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
Bioorganic & medicinal chemistry Mar, 2010 | Pubmed ID: 20188578
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines.
Bioorganic & medicinal chemistry May, 2010 | Pubmed ID: 20392646
Mutations in SOHLH1 gene associate with nonobstructive azoospermia.
Human mutation Jul, 2010 | Pubmed ID: 20506135
Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues.
European journal of medicinal chemistry Sep, 2010 | Pubmed ID: 20619511
Synthesis and biological properties of benzo-annulated rutaecarpines.
Biological & pharmaceutical bulletin , 2010 | Pubmed ID: 20930379
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2010 | Pubmed ID: 21048105
Rapid and Reliable Measurement for Evaluating Directly the Reactivity of N-Acetylcysteine with Glucose Degradation Products in Peritoneal Dialysis Fluids.
Analytical chemistry Feb, 2011 | Pubmed ID: 21299245
Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors.
Bioorganic & medicinal chemistry Mar, 2011 | Pubmed ID: 21353568
A peptide binding to dimerized translationally controlled tumor protein modulates allergic reactions.
Journal of molecular medicine (Berlin, Germany) Jun, 2011 | Pubmed ID: 21384150
Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor.
European journal of medicinal chemistry Jun, 2011 | Pubmed ID: 21419530
Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues.
Bioorganic & medicinal chemistry Apr, 2011 | Pubmed ID: 21429753
Design and evaluation of variants of the protein transduction domain originated from translationally controlled tumor protein.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences May, 2011 | Pubmed ID: 21440624
Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.
PloS one , 2011 | Pubmed ID: 21526198
Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
European journal of medicinal chemistry Aug, 2011 | Pubmed ID: 21601964
Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling.
Bioorganic & medicinal chemistry Jul, 2011 | Pubmed ID: 21684168
Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study.
Bioorganic & medicinal chemistry Sep, 2011 | Pubmed ID: 21873069
2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
Bioorganic chemistry Feb, 2012 | Pubmed ID: 22000119
Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
European journal of medicinal chemistry Jan, 2012 | Pubmed ID: 22318164
Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Feb, 2012 | Pubmed ID: 22333440
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