Youngjoo Kwon

Induced formation of a DNA bulge structure by a molecular wedge ligand-postactivated neocarzinostatin chromophore.

New complex of post-activated neocarzinostatin chromophore with DNA: bulge DNA binding from the minor groove.

A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.

Inhibition of colonic aberrant crypt foci by curcumin in rats is affected by age.

Small molecule transcription factor mimic.

Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives.

Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats.

Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis.

Synthesis of new xanthone analogues and their biological activity test--cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study.

Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.

P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis.

Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet.

Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors.

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex.

Aging alters acute apoptotic response to azoxymethane in the colon of rats.

First synthesis of 4'-selenonucleosides showing unusual Southern conformation.

New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor.

Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner.

2,2-dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties.

A rapid and sensitive screening system for human type I collagen with the aim of discovering potent anti-aging or anti-fibrotic compounds.

Age-related differential responses to curcumin-induced apoptosis during the initiation of colon cancer in rats.

Wrenchnolol derivative optimized for gene activation in cells.

Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors.

Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.

A concise synthesis of licochalcone E and its regio-isomer, licochalcone F.

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.

Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors.

2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.

New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers.

Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines.

Mutations in SOHLH1 gene associate with nonobstructive azoospermia.

Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues.

Synthesis and biological properties of benzo-annulated rutaecarpines.

Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.

Rapid and Reliable Measurement for Evaluating Directly the Reactivity of N-Acetylcysteine with Glucose Degradation Products in Peritoneal Dialysis Fluids.

Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors.

A peptide binding to dimerized translationally controlled tumor protein modulates allergic reactions.

Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor.

Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues.

Design and evaluation of variants of the protein transduction domain originated from translationally controlled tumor protein.

Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.

Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling.

Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study.

2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain.