Irina Smirnova

Institute of Thermal Separation Processes, Hamburg University of Technology

Affiliated withHamburg University of Technology

Research Area

Chemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2016

Other Publications

Article	Year
Mammalian metal response element-binding transcription factor-1 functions as a zinc sensor in yeast, but not as a sensor of cadmium or oxidative stress. Nucleic acids research\| PubMed ID: 12136095	2002
A mutation in the lactose permease of Escherichia coli that decreases conformational flexibility and increases protein stability. Biochemistry\| PubMed ID: 12627968	2003
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12730365	2003
Signal transduction pathways in mast cell granule-mediated endothelial cell activation. Mediators of inflammation\| PubMed ID: 12775357	2003
Structure and mechanism of the lactose permease of Escherichia coli. Science (New York, N.Y.)\| PubMed ID: 12893935	2003
The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport. FEBS letters\| PubMed ID: 14630326	2003
Role of YidC in folding of polytopic membrane proteins. The Journal of cell biology\| PubMed ID: 15067017	2004
Immunization with hepatitis C virus core gene triggers potent T-cell response, but affects CD4+ T-cells. Vaccine\| PubMed ID: 15068848	2004
Development of a bacterial biosensor for nitrotoluenes: the crystal structure of the transcriptional regulator DntR. Journal of molecular biology\| PubMed ID: 15210343	2004
Exercise attenuates diabetes-induced ultrastructural changes in rat cardiac tissue. Medicine and science in sports and exercise\| PubMed ID: 15514499	2004
Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools. Cell research\| PubMed ID: 15538970	2004
Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels. Pharmaceutical development and technology\| PubMed ID: 15581080	2004
Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli. Biochemistry\| PubMed ID: 15909981	2005
Ex vivo magnetic resonance imaging of rat spinal cord at 9.4 T. Magnetic resonance imaging\| PubMed ID: 15919607	2005
Characterization of alterations in diabetic myocardial tissue using high resolution MRI. The international journal of cardiovascular imaging\| PubMed ID: 16362172	2006
Manipulating phospholipids for crystallization of a membrane transport protein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16446422	2006
Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease. Journal of molecular biology\| PubMed ID: 16574149	2006
Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease. Journal of molecular biology\| PubMed ID: 16574153	2006
Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging. Cardiovascular diabetology\| PubMed ID: 16595006	2006
Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins. Cell biology international\| PubMed ID: 16949842	2006
Hepatitis C virus core protein transforms murine fibroblasts by promoting genomic instability. Cellular oncology : the official journal of the International Society for Cellular Oncology\| PubMed ID: 16988473	2006
Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli. The Journal of biological chemistry\| PubMed ID: 17003033	2006
Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS-induced lethality. European journal of immunology\| PubMed ID: 17039565	2006
Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17082374	2007
Genetic analysis of the innate immune responses in wild-derived inbred strains of mice. European journal of immunology\| PubMed ID: 17163447	2007
Direct sugar binding to LacY measured by resonance energy transfer. Biochemistry\| PubMed ID: 17176050	2006
Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17502603	2007
Longitudinal magnetic resonance imaging of spinal cord injury in mouse: changes in signal patterns associated with the inflammatory response. Magnetic resonance imaging\| PubMed ID: 17540277	2007
In vivo and in vitro investigation of transcriptional regulation by DntR. Journal of molecular biology\| PubMed ID: 17681542	2007
Sugar binding induces an outward facing conformation of LacY. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17925435	2007
Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1. The Journal of experimental medicine\| PubMed ID: 18268037	2008
A model-based time-reversal of left ventricular motion improves cardiac motion analysis using tagged MRI data. Biomedical engineering online\| PubMed ID: 18489766	2008
Protonation and sugar binding to LacY. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18567672	2008
Electron and proton transfer in the ba(3) oxidase from Thermus thermophilus. Journal of bioenergetics and biomembranes\| PubMed ID: 18752061	2008
A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. Infection and immunity\| PubMed ID: 18981241	2009
Electrophysiological characterization of LacY. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19383792	2009
A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. The Journal of experimental medicine\| PubMed ID: 19564352	2009
Residues in the H+ translocation site define the pKa for sugar binding to LacY. Biochemistry\| PubMed ID: 19689129	2009
Prosurvival and proapoptotic functions of ERK1/2 activation in murine thymocytes in vitro. Cellular immunology\| PubMed ID: 19914607	2010
Probing of the rates of alternating access in LacY with Trp fluorescence. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19959662	2009
Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes. Diabetology & metabolic syndrome\| PubMed ID: 20003276	2009
Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia. Cardiovascular diabetology\| PubMed ID: 20122173	2010
IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534545	2010
Delineating electrogenic reactions during lactose/H+ symport. Biochemistry\| PubMed ID: 20568736	2010
Functional role of Thr-312 and Thr-315 in the proton-transfer pathway in ba3 Cytochrome c oxidase from Thermus thermophilus. Biochemistry\| PubMed ID: 20677778	2010
Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat. Cardiovascular diabetology\| PubMed ID: 20860788	2010
Reduction of diffusion barriers in isolated rat islets improves survival, but not insulin secretion or transplantation outcome. Organogenesis\| PubMed ID: 20885858	2010
The alternating access transport mechanism in LacY. The Journal of membrane biology\| PubMed ID: 21161516	2011
Comparison of different pretreatment methods for lignocellulosic materials. Part II: Influence of pretreatment on the properties of rye straw lignin. Bioresource technology\| PubMed ID: 21208799	2011
Low insulin content of large islet population is present in situ and in isolated islets. Islets\| PubMed ID: 21325888	2011
Comparison of different pretreatment methods for lignocellulosic materials. Part I: conversion of rye straw to valuable products. Bioresource technology\| PubMed ID: 21349703	2011
Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFNγ-induced apoptosis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21606674	2011
Exercise training prevents endometrial hyperplasia and biomarkers for endometrial cancer in rat model of type 1 diabetes. Journal of clinical medicine research\| PubMed ID: 21629542	2010
Crystal structures of DntR inducer binding domains in complex with salicylate offer insights into the activation of LysR-type transcriptional regulators. Molecular microbiology\| PubMed ID: 21692874	2011
Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21896727	2011
Lactose permease and the alternating access mechanism. Biochemistry\| PubMed ID: 21995338	2011
Liporetro-D-peptides - a novel class of highly selective thrombin inhibitors. Thrombosis research\| PubMed ID: 22079445	2012
Experimental methods and prediction with COSMO-RS to determine partition coefficients in complex surfactant systems. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 22091584	2012
Sugar recognition by CscB and LacY. Biochemistry\| PubMed ID: 22106930	2011
Kinetic investigation of a solvent-free, chemoenzymatic reaction sequence towards enantioselective synthesis of a β-amino acid ester. Biotechnology and bioengineering\| PubMed ID: 22275046	2012
Time-dependent alterations in rat macrovessels with type 1 diabetes. Experimental diabetes research\| PubMed ID: 22315586	2012
Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T. Journal of neurochemistry\| PubMed ID: 22353009	2012
Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22797313	2012
Hydrothermal pentose to furfural conversion and simultaneous extraction with SC-CO2--kinetics and application to biomass hydrolysates. Bioresource technology\| PubMed ID: 22947445	2012
Role of protons in sugar binding to LacY. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23033496	2012
Construction of a two-parameter empirical model of left ventricle wall motion using cardiac tagged magnetic resonance imaging data. Biomedical engineering online\| PubMed ID: 23095713	2012
Partition coefficients of ionizable solutes in mixed nonionic/ionic micellar systems. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 23237203	2013
COSMO-RS for the prediction of the retention behavior in micellar liquid chromatography based on partition coefficients of non-dissociated and dissociated solutes. Journal of chromatography. A\| PubMed ID: 23273634	2013
Pressure assisted stabilization of biocatalysts at elevated temperatures: characterization by dynamic light scattering. Biotechnology and bioengineering\| PubMed ID: 23280599	2013
Prediction of micelle/water and liposome/water partition coefficients based on molecular dynamics simulations, COSMO-RS, and COSMOmic. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 23398189	2013
Combination of COSMOmic and molecular dynamics simulations for the calculation of membrane-water partition coefficients. Journal of computational chemistry\| PubMed ID: 23447371	2013
Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23671103	2013
An efficient oxyfunctionalization of quinopimaric acid derivatives with ozone. Natural product communications\| PubMed ID: 23678794	2013
Comparison of pretreatment methods for rye straw in the second generation biorefinery: effect on cellulose, hemicellulose and lignin recovery. Bioresource technology\| PubMed ID: 23748091	2013
Variations in rodent models of type 1 diabetes: islet morphology. Journal of diabetes research\| PubMed ID: 23762878	2013
Molecular dynamics simulation of SDS and CTAB micellization and prediction of partition equilibria with COSMOmic. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 23941607	2013
Single mutations that redirect internal proton transfer in the ba3 oxidase from Thermus thermophilus. Biochemistry\| PubMed ID: 24004023	2013
Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24184555	2013
Vertical convective coassembly of refractory YSZ inverse opals from crystalline nanoparticles. ACS applied materials & interfaces\| PubMed ID: 24319984	2013
Structure of sugar-bound LacY. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24453216	2014
Solubilization in mixed micelles studied by molecular dynamics simulations and COSMOmic. The journal of physical chemistry. B\| PubMed ID: 24533791	2014
Synthesis of an organic conductive porous material using starch aerogels as template for chronic invasive electrodes. Materials science & engineering. C, Materials for biological applications\| PubMed ID: 24582238	2014
Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice. The Journal of biological chemistry\| PubMed ID: 24706750	2014
Real-time conformational changes in LacY. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24872451	2014
Neuroanatomical distribution of mechanoreceptors in the human cadaveric shoulder capsule and labrum. Journal of anatomy\| PubMed ID: 25040358	2014
Synthesis and anticancer activity of quinopimaric and maleopimaric acids’ derivatives. Bioorganic & medicinal chemistry\| PubMed ID: 25440729	2014
Outward-facing conformers of LacY stabilized by nanobodies. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25512549	2014
One-pot synthesis of hollongdione from dipterocarpol. Natural product communications\| PubMed ID: 25522528	2014
Biocatalytic carboxylation of phenol derivatives: kinetics and thermodynamics of the biological Kolbe-Schmitt synthesis. The FEBS journal\| PubMed ID: 25652582	2015
Synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives. Bioorganic & medicinal chemistry\| PubMed ID: 26372075	2015
Transient conformers of LacY are trapped by nanobodies. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26512108	2015
Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26685207	2016
Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26798068	2016
Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids. Natural product communications\| PubMed ID: 26996014	2016