Irina Smirnova

Mammalian metal response element-binding transcription factor-1 functions as a zinc sensor in yeast, but not as a sensor of cadmium or oxidative stress.

A mutation in the lactose permease of Escherichia coli that decreases conformational flexibility and increases protein stability.

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility.

Signal transduction pathways in mast cell granule-mediated endothelial cell activation.

Structure and mechanism of the lactose permease of Escherichia coli.

The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport.

Role of YidC in folding of polytopic membrane proteins.

Immunization with hepatitis C virus core gene triggers potent T-cell response, but affects CD4+ T-cells.

Development of a bacterial biosensor for nitrotoluenes: the crystal structure of the transcriptional regulator DntR.

Exercise attenuates diabetes-induced ultrastructural changes in rat cardiac tissue.

Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools.

Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels.

Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli.

Ex vivo magnetic resonance imaging of rat spinal cord at 9.4 T.

Characterization of alterations in diabetic myocardial tissue using high resolution MRI.

Manipulating phospholipids for crystallization of a membrane transport protein.

Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease.

Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease.

Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging.

Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins.

Hepatitis C virus core protein transforms murine fibroblasts by promoting genomic instability.

Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli.

Mice expressing high levels of soluble CD14 retain LPS in the circulation and are resistant to LPS-induced lethality.

Exercise training improves cardiac performance in diabetes: in vivo demonstration with quantitative cine-MRI analyses.

Genetic analysis of the innate immune responses in wild-derived inbred strains of mice.

Direct sugar binding to LacY measured by resonance energy transfer.

Single-molecule FRET reveals sugar-induced conformational dynamics in LacY.

Longitudinal magnetic resonance imaging of spinal cord injury in mouse: changes in signal patterns associated with the inflammatory response.

In vivo and in vitro investigation of transcriptional regulation by DntR.

Sugar binding induces an outward facing conformation of LacY.

Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1.

A model-based time-reversal of left ventricular motion improves cardiac motion analysis using tagged MRI data.

Protonation and sugar binding to LacY.

Electron and proton transfer in the ba(3) oxidase from Thermus thermophilus.

A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth.

Electrophysiological characterization of LacY.

A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice.

Residues in the H+ translocation site define the pKa for sugar binding to LacY.

Prosurvival and proapoptotic functions of ERK1/2 activation in murine thymocytes in vitro.

Probing of the rates of alternating access in LacY with Trp fluorescence.

Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes.

Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia.

IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50.

Delineating electrogenic reactions during lactose/H+ symport.

Functional role of Thr-312 and Thr-315 in the proton-transfer pathway in ba3 Cytochrome c oxidase from Thermus thermophilus.

Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat.

Reduction of diffusion barriers in isolated rat islets improves survival, but not insulin secretion or transplantation outcome.

The alternating access transport mechanism in LacY.

Comparison of different pretreatment methods for lignocellulosic materials. Part II: Influence of pretreatment on the properties of rye straw lignin.

Low insulin content of large islet population is present in situ and in isolated islets.

Comparison of different pretreatment methods for lignocellulosic materials. Part I: conversion of rye straw to valuable products.

Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFNγ-induced apoptosis.

Exercise training prevents endometrial hyperplasia and biomarkers for endometrial cancer in rat model of type 1 diabetes.

Crystal structures of DntR inducer binding domains in complex with salicylate offer insights into the activation of LysR-type transcriptional regulators.

Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding.

Lactose permease and the alternating access mechanism.

Liporetro-D-peptides - a novel class of highly selective thrombin inhibitors.

Experimental methods and prediction with COSMO-RS to determine partition coefficients in complex surfactant systems.

Sugar recognition by CscB and LacY.

Kinetic investigation of a solvent-free, chemoenzymatic reaction sequence towards enantioselective synthesis of a β-amino acid ester.

Time-dependent alterations in rat macrovessels with type 1 diabetes.

Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo ¹H MR spectroscopy at 9.4 T.

Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol.

Hydrothermal pentose to furfural conversion and simultaneous extraction with SC-CO2--kinetics and application to biomass hydrolysates.

Role of protons in sugar binding to LacY.

Construction of a two-parameter empirical model of left ventricle wall motion using cardiac tagged magnetic resonance imaging data.

Partition coefficients of ionizable solutes in mixed nonionic/ionic micellar systems.

COSMO-RS for the prediction of the retention behavior in micellar liquid chromatography based on partition coefficients of non-dissociated and dissociated solutes.

Pressure assisted stabilization of biocatalysts at elevated temperatures: characterization by dynamic light scattering.

Prediction of micelle/water and liposome/water partition coefficients based on molecular dynamics simulations, COSMO-RS, and COSMOmic.

Combination of COSMOmic and molecular dynamics simulations for the calculation of membrane-water partition coefficients.

Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation.

An efficient oxyfunctionalization of quinopimaric acid derivatives with ozone.

Comparison of pretreatment methods for rye straw in the second generation biorefinery: effect on cellulose, hemicellulose and lignin recovery.

Variations in rodent models of type 1 diabetes: islet morphology.

Molecular dynamics simulation of SDS and CTAB micellization and prediction of partition equilibria with COSMOmic.

Single mutations that redirect internal proton transfer in the ba3 oxidase from Thermus thermophilus.

Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides.

Vertical convective coassembly of refractory YSZ inverse opals from crystalline nanoparticles.

Structure of sugar-bound LacY.

Solubilization in mixed micelles studied by molecular dynamics simulations and COSMOmic.

Synthesis of an organic conductive porous material using starch aerogels as template for chronic invasive electrodes.

Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice.

Real-time conformational changes in LacY.

Neuroanatomical distribution of mechanoreceptors in the human cadaveric shoulder capsule and labrum.

Synthesis and anticancer activity of quinopimaric and maleopimaric acids’ derivatives.

Outward-facing conformers of LacY stabilized by nanobodies.

One-pot synthesis of hollongdione from dipterocarpol.

Biocatalytic carboxylation of phenol derivatives: kinetics and thermodynamics of the biological Kolbe-Schmitt synthesis.

Synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives.

Transient conformers of LacY are trapped by nanobodies.

Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo.

Inhibition of Alpha-Glucosidase by Synthetic Derivatives of Lupane, Oleanane, Ursane and Dammarane Triterpenoids.