Sylvie Lesage

Spinal cord compression of dual etiology, multiple myeloma and spinal tuberculosis.

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

Aire regulates negative selection of organ-specific T cells.

T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form.

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

A cell death pathway induced by antibody-mediated cross-linking of CD45 on lymphocytes.

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs.

Cutting edge: CD47 controls the in vivo proliferation and homeostasis of peripheral CD4+ CD25+ Foxp3+ regulatory T cells that express CD103.

Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes.

Cutting edge: genetic characterization of IFN-producing killer dendritic cells.

Implication of the CD47 pathway in autoimmune diabetes.

Interleukin-10 limits the expansion of immunoregulatory CD4-CD8- T cells in autoimmune-prone non-obese diabetic mice.

Molecular and genetic parameters defining T-cell clonal selection.

Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation.

The size of the plasmacytoid dendritic cell compartment is a multigenic trait dominated by a locus on mouse chromosome 7.

A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells.

Unusual selection and peripheral homeostasis for immunoregulatory CD4(-)  CD8(-) T cells.

Immunoregulatory CD4(-)CD8(-) T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer.

The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility.

Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice.

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells.

The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.

The mouse idd2 locus is linked to the proportion of immunoregulatory double-negative T cells, a trait associated with autoimmune diabetes resistance.

Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response.

Functional characterization of CaVα2δ mutations associated with sudden cardiac death.

Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12.

Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity.

NK Cell Proportion and Number Are Influenced by Genetic Loci on Chromosomes 8, 9, and 17.

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.