Jian Ding

Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evaluation of novel inhibitors.

Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction.

Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment.

AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo.

Recovery of stereopsis through perceptual learning in human adults with abnormal binocular vision.

Biogenic hierarchical TiO₂/SiO₂ derived from rice husk and enhanced photocatalytic properties for dye degradation.

The short-time treatment with curcumin sufficiently decreases cell viability, induces apoptosis and copper enhances these effects in multidrug-resistant K562/A02 cells.

Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix.

Characterization of dihydroartemisinin-resistant colon carcinoma HCT116/R cell line.

Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents.

The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.

Constituents of Trigonostemon heterophyllus.

Functional motor nerve regeneration without motor-sensory specificity following end-to-side neurorrhaphy: an experimental study.

Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors.

TLR2 activation enhances HIV nuclear import and infection through T cell activation-independent and -dependent pathways.

Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.

AL3810, a multi-tyrosine kinase inhibitor, exhibits potent anti-angiogenic and anti-tumour activity via targeting VEGFR, FGFR and PDGFR.

Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR.

Discovery of LFF571: an investigational agent for Clostridium difficile infection.

Inhibition of chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells.

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model.

Cytotoxic diterpenoids from Sapium insigne.

Bacteria-directed construction of hollow TiO2 micro/nanostructures with enhanced photocatalytic hydrogen evolution activity.

Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling.

In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers.

Newly discovered angiogenesis inhibitors and their mechanisms of action.

Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.

Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity.

Celebrating the 80th anniversary of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM).

Characterization of the conversion between CD133+ and CD133- cells in colon cancer SW620 cell line.

Chemical constituents from Brucea javanica.

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.

Crosstalk between EGFR and integrin affects invasion and proliferation of gastric cancer cell line, SGC7901.

Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.

[Prevalence of allergic rhinitis and survey analysis of health service needs and utilization in Qingdao area].

The fixation and saccade P3.

Binocular combination of phase and contrast explained by a gain-control and gain-enhancement model.

Binocular combination in abnormal binocular vision.

Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.

Characteristics and kinetics of ammonia and N2O emissions of aged refuse irrigated from landfill leachate.

Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo.

mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.

Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors.

Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway.

Multiple heterotopic ossification of scar following degloving injury: a case report.

Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).

Cardioprotection via Preserved Mitochondrial Structure and Function in the mPer2-mutant Mouse Myocardium.

Molecular characterization and promoter analysis of crustacean heat shock protein 10 in Scylla paramemosain.

Translation and linguistic validation of the Pediatric Patient-Reported Outcomes Measurement Information System measures into simplified Chinese using cognitive interviewing methodology.

A pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth.

Prediction of microRNAs associated with human diseases based on weighted k most similar neighbors.

Study on discrimination of white tea and albino tea based on near-infrared spectroscopy and chemometrics.

Differential profiles of immune mediators and in vitro HIV infectivity between endocervical and vaginal secretions from women with Chlamydia trachomatis infection: a pilot study.

Aberrant TIG1 methylation associated with its decreased expression and clinicopathological significance in hepatocellular carcinoma.

Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer.

WITHDRAWN: Design, synthesis and biological evaluation of 3-substituted-4-anilinequinoline as EGFR tyrosine kinase inhibitors.

[Diagnosis and treatment of ketamine-associated cystitis: a report of 3 cases and literature review].

Anti-HIV activity of human defensin 5 in primary CD4+ T cells under serum-deprived conditions is a consequence of defensin-mediated cytotoxicity.

Correction: Prediction of microRNAs Associated with Human Diseases Based on Weighted k Most Similar Neighbors.

Draft genome of the kiwifruit Actinidia chinensis.

Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro.

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor.

O-GlcNAcylation of cofilin promotes breast cancer cell invasion.

Yhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells.

Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes.

Molecularly targeted cancer therapy: some lessons from the past decade.

DW09849, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110α (H1047R).

Rebalancing binocular vision in amblyopia.

Cytotoxic dinorditerpenoids from Drypetes perreticulata.

Spontaneous ventral urethral fistula in a young man whose mother had a retained IUD in uterus during the gestation.

Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.

Scorpion venoms as a potential source of novel cancer therapeutic compounds.

Enhanced porcine circovirus Cap protein production by Pichia pastoris with a fuzzy logic DO control based methanol/sorbitol co-feeding induction strategy.

Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy.

[Effects of electroacupuncture intervention combined with polysaccharide of Gastrodia elata Blume on expression of nestin and cytokines of neural stem cells in the dentate gyrus of cerebral ischemia rats].

MCL-1 degradation mediated by JNK activation via MEKK1/TAK1-MKK4 contributes to anticancer activity of new tubulin inhibitor MT189.

The relationship between proton pump inhibitor adherence and fracture risk in the elderly.

HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.

Diterpenoids from Croton laui and their cytotoxic and antimicrobial activities.

SOMG-833, a novel selective c-MET inhibitor, blocks c-MET-dependent neoplastic effects and exerts antitumor activity.

Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases.

17β-estradiol protects primary macrophages against HIV infection through induction of interferon-alpha.

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.

Chemical constituents from the heartwood of Haematoxylon campechianum as protein tyrosine kinase inhibitors.

Identification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin.

SOMCL-863, a novel, selective and orally bioavailable small-molecule c-Met inhibitor, exhibits antitumor activity both in vitro and in vivo.

Potential of mesenchymal stem cells by adenovirus-mediated erythropoietin gene therapy approaches for bone defect.

Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.

Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors.

Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.

JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin.

G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro.

Novel metal complexes of naphthalimide-cyclam conjugates as potential multi-target receptor tyrosine kinase (RTK) inhibitors: synthesis and biological evaluation.

Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes.

Ten years' experience for hypospadias repair: combined buccal mucosa graft and local flap for urethral reconstruction.

Study of the medial group retropharyngeal node metastasis from nasopharyngeal carcinoma based on 3100 newly diagnosed cases.

Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.

Controlled synthesis of multilayered gold nanoshells for enhanced photothermal therapy and SERS detection.

Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer.

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.

Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia.

Correlation between E-cadherin-regulated cell adhesion and human osteosarcoma MG-63 cell anoikis.

Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting.

G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation.

Accurately mapping the location of the binding site for the interaction between hepatitis B virus X protein and cytochrome c oxidase III.

The emotional distress of children with cancer in China: an item response analysis of C-Ped-PROMIS Anxiety and Depression short forms.

[The classification and surgical treatment of the terminal phalanx of congenital thumb duplication ].

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation.

Prediction of potential disease-associated microRNAs based on random walk.

Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.

Molecular evolution and phylogenetic analysis of eight COL superfamily genes in group I related to photoperiodic regulation of flowering time in wild and domesticated cotton (Gossypium) species.

Targeting PI3Kδ: emerging therapy for chronic lymphocytic leukemia and beyond.

Limonoids and Triterpenoids from Dysoxylum mollissimum var. glaberrimum.

Evaluation of left ventricular function by three-dimensional speckle-tracking echocardiography in patients with myocardial bridging of the left anterior descending coronary artery.

Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition.

Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement.

Nerve defect repair by differentiated adipose-derived stem cells and chondroitinase ABC-treated acellular nerves.

Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment.

Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents.

Plasma antioxidant status and motor features in de novo Chinese Parkinson's disease patients.

[Vaginoplasty with autologous buccal micromucosa combined with acellular allogenic dermal matrix].

DCLAK11, a multi-tyrosine kinase inhibitor, exhibits potent antitumor and antiangiogenic activity in vitro.

Reduced plasma serotonin and 5-hydroxyindoleacetic acid levels in Parkinson's disease are associated with nonmotor symptoms.

Trbp regulates heart function through microRNA-mediated Sox6 repression.

Over-nutrient environment during both prenatal and postnatal development increases severity of islet injury, hyperglycemia, and metabolic disorders in the offspring.

Effect of Ethanol Accumulation on Porcine Interferon-α Production by Pichia pastoris and Activities of Key Enzymes in Carbon Metabolism.

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.

The association between clinically relevant anxiety and other non-motor symptoms in Parkinson's disease.

Integrin α4β7 Expression Increases HIV Susceptibility in Activated Cervical CD4+ T Cells by an HIV Attachment-Independent Mechanism.

[Effects of electroacupuncture combined with polysaccharide of gastrodia elate blume on expression of nestin and stem cell factor in thalamic ventroposterolateral nucleus in rats with focal cerebral ischemia].

2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M).

Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.

T Lymphocyte Subsets and Cytokines in Rats Transplanted with Adipose-Derived Mesenchymal Stem Cells and Acellular Nerve for Repairing the Nerve Defects.

PI3K isoform-selective inhibitors: next-generation targeted cancer therapies.

Precision cancer medicine: where to target?

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.

Risk of Coronary Heart Disease in Different Criterion of Impaired Fasting Glucose: A Meta-Analysis.

Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells.

Enhancing acetone biosynthesis and acetone-butanol-ethanol fermentation performance by co-culturing Clostridium acetobutylicum/Saccharomyces cerevisiae integrated with exogenous acetate addition.

Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: design, synthesis, and structure-activity relationship study.

JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification.

c-Myc alterations confer therapeutic response and acquired resistance to c-Met inhibitors in MET-addicted cancers.

Enhancing Butanol Production under the Stress Environments of Co-Culturing Clostridium acetobutylicum/Saccharomyces cerevisiae Integrated with Exogenous Butyrate Addition.

Mystery of Trbp, tale of a RBP in the miRNA pathway.

Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice.

Unique dose-dependent effects of the human pregnancy hormone estriol on the ratio of blood IgM to IgG in female mice.

(Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level.

Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK.

V1 neurons respond to luminance changes faster than contrast changes.

Regional homogeneity alterations differentiate between tremor dominant and postural instability gait difficulty subtypes of Parkinson's disease.

Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation.

HIV Vaccination, is Breakthrough Underway?

Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.

[EFFECTIVENESS OF DORSAL PENTAGONAL FLAP FOR RECONSTRUCTION OF THE WEB SPACE IN CONGENITAL TOE SYNDACTYLY].

Essential role of proteasomes in maintaining self-renewal in neural progenitor cells.

DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.

The Neural Basis of Postural Instability Gait Disorder Subtype of Parkinson's Disease: A PET and fMRI Study.

Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.

G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells.

Expression and purification of FGF21 in Pichia pastoris and its effect on fibroblast-cell migration.

Binocular contrast discrimination needs monocular multiplicative noise.

Molybdenum carbide as an efficient catalyst for low-temperature hydrogenation of dimethyl oxalate.

[Predictive value of radiological parameter for re-displacement of conservative treatment of distal radius fracture].

Anticancer drug combinations, how far we can go through?

Mannolides A-C with an Intact Diterpenoid Skeleton Providing Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids.

Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2).

Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.

[Effect of Electroacupuncture Intervention Combined with Gastrodin Administration on Neurological Function, Nogo-A and NgR Expression in the Frontal Lobe Cortex of Focal Cerebral Ischemia Rats].

Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle.

Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities.

Ciliatonoids A and B, Two Limonoids from Toona ciliata.

Alterations of functional and structural connectivity of freezing of gait in Parkinson's disease.

Interplay between chronic kidney disease (CKD) and upper tract urothelial carcinomas (UUC): foe or friend?

Recovering stereo vision by squashing virtual bugs in a virtual reality environment.

Research and industrialization progress of recovering alumina from fly ash: A concise review.

BAFF overexpression increases lymphocytic infiltration in Sjögren's target tissue, but only inefficiently promotes ectopic B-cell differentiation.

Antibacterial and Solubility Optimization of Thiomuracin A.

The Effect of Inducible Nitric Oxide Synthase on Multiterritory Perforator Flap Survival in Rats.

Long-term effect of heavy-metal pollution on diversity of gastrointestinal microbial community of Bufo raddei.

Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

c-Myc alteration determines the therapeutic response to FGFR inhibitors.

Hydrophilic MoSe2 Nanosheets as Effective Photothermal Therapy Agents and Their Application in Smart Devices.

Postoperative Growth in Radial Polydactyly: A Clinical Study.

HIV Vaccine for Prevention and Cure, A Mission Possible.

Reverse polyaxial less invasive stabilization systems for treatment of femoral intertrochanteric fractures of the distal femur.

Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells.

Construction of Epidermal Growth Factor Receptor Peptide Magnetic Nanovesicles with Lipid Bilayers for Enhanced Capture of Liver Cancer Circulating Tumor Cells.

Antitumor action of CDK inhibitor LS-007 as a single agent and in combination with ABT-199 against human acute leukemia cells.

Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration.

Comprehensive Transcriptome Profiling Reveals Long Noncoding RNA Expression and Alternative Splicing Regulation during Fruit Development and Ripening in Kiwifruit (Actinidia chinensis).

Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.

Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer.

Magnetic solid-phase extraction based on graphene oxide for the determination of lignans in sesame oil.

Identification of candidate genes from the SAD gene family in cotton for determination of cottonseed oil composition.

Identification of Novel CD4+ T Cell Subsets in the Target Tissue of Sjögren's Syndrome and Their Differential Regulation by the Lymphotoxin/LIGHT Signaling Axis.

SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials.

Relationship between the plasma levels of neurodegenerative proteins and motor subtypes of Parkinson's disease.

Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution.