Michal Toborek

Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity.

Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells.

PCB-induced oxidative stress in endothelial cells: modulation by nutrients.

Linoleic acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanism.

Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence.

Measurement of inflammatory properties of fatty acids in human endothelial cells.

Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation.

Methamphetamine activates DNA binding of specific redox-responsive transcription factors in mouse brain.

Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells.

HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium.

Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain.

Cholesterol attenuates linoleic acid-induced endothelial cell activation.

2,2',4,6,6'-pentachlorobiphenyl (PCB 104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB.

PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis.

Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells.

HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells.

Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.

HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain.

Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons.

Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors.

Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells.

Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling.

Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction.

Emerging issues: nutritional awareness in environmental toxicology.

Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma.

VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells.

Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells.

Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells.

Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism.

Gene expression profile in interleukin-4-stimulated human vascular endothelial cells.

Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue.

Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor.

Nicotine attenuates morphological deficits in a contusion model of spinal cord injury.

Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells.

HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation.

HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells.

Mechanisms of the blood-brain barrier disruption in HIV-1 infection.

Modification of environmental toxicity by nutrients: implications in atherosclerosis.

Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice.

HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier.

Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling.

c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line.

Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain.

Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells.

ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons.

The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells.

Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis.

The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells.

Zinc deficiency alters lipid metabolism in LDL receptor deficient mice treated with rosiglitazone.

PPARalpha ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis.

Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood-brain barrier.

Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells.

Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells.

ORAL ADMINISTRATION OF PCBs INDUCES PROINFLAMMATORY AND PROMETASTATIC RESPONSES.

Pcbs and tight junction expression.

Role of caveolin-1 in EGCG-mediated protection against linoleic-acid-induced endothelial cell activation.

Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.

Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway.

PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells.

Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells.

The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation.

Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature.

Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling.

Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury.

Vessel microport technique for applications in cerebrovascular research.

PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities.

Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene.

Zinc nutritional status modulates expression of ahr-responsive p450 enzymes in vascular endothelial cells.

Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent.

Induction of gene pattern changes associated with dysfunctional lipid metabolism induced by dietary fat and exposure to a persistent organic pollutant.

Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs.

NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.

Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells.

HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin.

Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation.

Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells.

Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression.

The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants.

Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice.

Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke.

Epigallocatechin gallate-mediated protection against tumor necrosis factor-α-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependent.

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls.

Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases.

Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.

Epigallocatechin-gallate stimulates NF-E2-related factor and heme oxygenase-1 via caveolin-1 displacement.

EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer.

HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level.

HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits.

Impact of nutrition on PCB toxicity.

PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling.

Diffuse optical monitoring of repeated cerebral ischemia in mice.

HIV-1 Tat triggers nuclear localization of ZO-1 via Rho signaling and cAMP response element-binding protein activation.

Proinflammatory adhesion molecules facilitate polychlorinated biphenyl-mediated enhancement of brain metastasis formation.

Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells.

EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes.

Autophagy is involved in nanoalumina-induced cerebrovascular toxicity.

Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood-brain barrier via TLR4/IRF-3 signaling.

Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier.

Cerebrovascular toxicity of PCB153 is enhanced by binding to silica nanoparticles.

Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier.

Exercise attenuates PCB-induced changes in the mouse gut microbiome.

Supplementation with selenium-enriched yeast attenuates brain metastatic growth.

TLR4 signaling is involved in brain vascular toxicity of PCB153 bound to nanoparticles.

Targeting the therapeutic effects of exercise on redox-sensitive mechanisms in the vascular endothelium during tumor progression.

Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood-brain barrier.

Endovascular embolization of varicoceles using n-butyl cyanoacrylate (NBCA) glue.

Methamphetamine-induced occludin endocytosis is mediated by the Arp2/3 complex-regulated actin rearrangement.

PPAR agonist-mediated protection against HIV Tat-induced cerebrovascular toxicity is enhanced in MMP-9-deficient mice.

HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-β/Smad signaling.

Interactions of PCBs with human serum albumin: in vitro spectroscopic study.

Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.

Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.

Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation.

Transcriptional profile of HIV-induced nuclear translocation of amyloid β in brain endothelial cells.

Selenoglycoproteins attenuate adhesion of tumor cells to the brain microvascular endothelium via a process involving NF-κB activation.

Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz.

Exercise maintains blood-brain barrier integrity during early stages of brain metastasis formation.

Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2.

Environmental PCBs in Guánica Bay, Puerto Rico: implications for community health.

Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation.

Dietary Selenium Supplementation Modulates Growth of Brain Metastatic Tumors and Changes the Expression of Adhesion Molecules in Brain Microvessels.

Biological activity of selenium: Revisited.

Blood-brain barrier remodeling during brain metastasis formation.

Extracellular vesicles of the blood-brain barrier.

Solving the Blood-Brain Barrier Challenge for the Effective Treatment of HIV Replication in the Central Nervous System.

Exercise protects against methamphetamine-induced aberrant neurogenesis.

Development of magneto-plasmonic nanoparticles for multimodal image-guided therapy to the brain.

Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology.

Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity.

Methamphetamine increases HIV infectivity in neural progenitor cells.

Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway.

HIV Alters Gap Junction-Mediated Intercellular Communication in Human Brain Pericytes.

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis.

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition.

Effects of coating materials on antibacterial properties of industrial and sunscreen-derived titanium-dioxide nanoparticles on Escherichia coli.

Chronic Ingestion of Sodium and Potassium Bicarbonate, with Potassium, Magnesium and Calcium Citrate Improves Anaerobic Performance in Elite Soccer Players.

Targeted Mitochondrial COQ Delivery Attenuates Antiretroviral-Drug-Induced Senescence of Neural Progenitor Cells.

Blood-brain barrier pericytes as a target for HIV-1 infection.

Methamphetamine-associated cognitive decline is attenuated by neutralizing IL-1 signaling.

Treatment of antibiotic-resistant bacteria by encapsulation of ZnO nanoparticles in an alginate biopolymer: Insights into treatment mechanisms.

Targeting the HIV-infected brain to improve ischemic stroke outcome.

Cerebral Vascular Toxicity of Antiretroviral Therapy.

Antibacterial effects of graphene- and carbon-nanotube-based nanohybrids on Escherichia coli: Implications for treating multidrug-resistant bacteria.

Opioid antagonists as potential therapeutics for ischemic stroke.

Toxicity of ZnO/TiO -conjugated carbon-based nanohybrids on the coastal marine alga Thalassiosira pseudonana.

Selective Disruption of the Blood-Brain Barrier by Zika Virus.

Viral Vector-Mediated Gene Transfer of Glutamic Acid Decarboxylase for Chronic Pain Treatment: A Literature Review.

Extracellular vesicle-mediated amyloid transfer to neural progenitor cells: implications for RAGE and HIV infection.

The Effect of Neurofeedback Training on the Visual Processing Efficiency in Judo Athletes.

Physical activity reduces anxiety and regulates brain fatty acid synthesis.

HIV-1 and Amyloid Beta Remodel Proteome of Brain Endothelial Extracellular Vesicles.

Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy.

Urinary incontinence in women: biofeedback as an innovative treatment method.

The Paradox of HIV Blood-Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies.

Substances of abuse and the blood brain barrier: Interactions with physical exercise.

Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes.

Expression of SARS-CoV-2-related Receptors in Cells of the Neurovascular Unit: Implications for HIV-1 Infection.

Extracellular vesicles regulate gap junction-mediated intercellular communication and HIV-1 infection of human neural progenitor cells.

Methamphetamine Enhances HIV-Induced Aberrant Proliferation of Neural Progenitor Cells via the FOXO3-Mediated Mechanism.

In Vivo Targeting of the Neurovascular Unit: Challenges and Advancements.

Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection.

Brain-Accumulating Nanoparticles for Assisting Astrocytes to Reduce Human Immunodeficiency Virus and Drug Abuse-Induced Neuroinflammation and Oxidative Stress.

Synergistic Impairment of the Neurovascular Unit by HIV-1 Infection and Methamphetamine Use: Implications for HIV-1-Associated Neurocognitive Disorders.

Correction to: Methamphetamine Enhances HIV-Induced Aberrant Proliferation of Neural Progenitor Cells via the FOXO3-Mediated Mechanism.

Bicarbonate supplementation via lactate efflux improves anaerobic and cognitive performance in elite combat sport athletes.

Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study.

Brain barriers virtual: an interim solution or future opportunity?

Successful correction of hyperglycemia is critical for weight loss and a decrease in cardiovascular risk in obese patients.

Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke.

SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodeling.

SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodeling.

Pitfalls of Antiretroviral Therapy: Current Status and Long-Term CNS Toxicity.

Circadian disruption alters gut barrier integrity via a ß-catenin-MMP-related pathway.

Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19.