Kunitada Shimotohno

RelA suppresses the Wnt/beta-catenin pathway without exerting trans-acting transcriptional ability.

Subgenomic replicon derived from a cell line infected with the hepatitis C virus.

Hepatitis C virus and its roles in cell proliferation.

Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts.

The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression.

Gerbils of a seizure-sensitive strain have a mitochondrial inner membrane protein with different isoelectric points from those of a seizure-resistant strain.

Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein.

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

p21(Waf1/Cip1/Sdi1) prevents apoptosis as well as stimulates growth in cells transformed or immortalized by human T-cell leukemia virus type 1-encoded tax.

Establishment of a hepatitis C virus subgenomic replicon derived from human hepatocytes infected in vitro.

SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax.

Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication.

Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4.

[How can we improve the system to analyze HCV replication system?].

Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.

Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes.

The roles of hepatitis C virus proteins in modulation of cellular functions: a novel action mechanism of the HCV core protein on gene regulation by nuclear hormone receptors.

Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon.

Down-regulation of viral replication by adenoviral-mediated expression of siRNA against cellular cofactors for hepatitis C virus.

Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification.

Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner.

Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53.

Establishment of hepatitis C virus replicon cell lines possessing interferon-resistant phenotype.

[Gene organization of hepatitis C virus and its sequence diversity].

[Processing of HCV precursor polyprotein].

Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3.

cDNA microarray analysis to compare HCV subgenomic replicon cells with their cured cells.

The role of notch signaling in the development of intrahepatic bile ducts.

HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein.

Suppression of hepatitis C virus replicon by TGF-beta.

p21WAF1 modulates NF-kappaB signaling and induces anti-apoptotic protein Bcl-2 in Tax-expressing rat fibroblast.

Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR.

Centrosomal P4.1-associated protein is a new member of transcriptional coactivators for nuclear factor-kappaB.

Genetic variation and dynamics of hepatitis C virus replicons in long-term cell culture.

Role of cyclophilin B in activation of interferon regulatory factor-3.

Analysis of the 5' end structure of HCV subgenomic RNA replicated in a Huh7 cell line.

Exploiting cis-acting replication elements to direct hepatitis C virus-dependent transgene expression.

Identification of a novel p300-specific-associating protein, PRS1 (phosphoribosylpyrophosphate synthetase subunit 1).

Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.

Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059.

Inhibition of hepatitis C virus replication by pol III-directed overexpression of RNA decoys corresponding to stem-loop structures in the NS5B coding region.

Interferon resistance of hepatitis C virus replicon-harbouring cells is caused by functional disruption of type I interferon receptors.

[Current approaches for developing new anti-HCV agents and analyses of HCV replication using anti-HCV agents].

High-throughput screening of low molecular weight NS3-NS4A protease inhibitors using a fluorescence resonance energy transfer substrate.

Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon.

Epigenetic silencing of interferon-inducible genes is implicated in interferon resistance of hepatitis C virus replicon-harboring cells.

Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811.

Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons.

Diverse effects of cyclosporine on hepatitis C virus strain replication.

Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.

Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b.

Inhibition of hcv replication in HCV replicon by shRNAs.

High expression of APOBEC3G in patients infected with hepatitis C virus.

Helper virus-independent trans-replication of hepatitis C virus-derived minigenome.

Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes.

RNAi expression mediated inhibition of HCV replication.

Suppression of HCV RNA replication by baculovirus-mediated shRNA expression.

The expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family.

In vitro infection of immortalized primary hepatocytes by HCV genotype 4a and inhibition of virus replication by cyclosporin.

Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy.

Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b with the potentiality to generate cytotoxic T lymphocytes in HCV1b(+) HLA-A24(+) patients.

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.

BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3.

Anti-hepatitis C virus activity of tamoxifen reveals the functional association of estrogen receptor with viral RNA polymerase NS5B.

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.

The lipid droplet is an important organelle for hepatitis C virus production.

Up-regulation of hepatitis C virus replication by human T cell leukemia virus type I-encoded Tax protein.

5'-O-masked 2'-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents.

Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

Suppression of hepatitis C virus core protein by short hairpin RNA expression vectors in the core protein expression Huh-7 cells.

Possible molecular mechanism of the relationship between NS5B polymorphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment.

Isolation and gene analysis of interferon alpha-resistant cell clones of the hepatitis C virus subgenome.

[Strategy of HCV proliferation].

Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.

Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.

Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination.

3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV.

Regulation of viral recognition signaling by ubiquitin modification.

Regulation of the hepatitis C virus genome replication by miR-199a.

Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3.

TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.

Genetic analysis of hepatitis C virus with defective genome and its infectivity in vitro.

Strain-dependent viral dynamics and virus-cell interactions in a novel in vitro system supporting the life cycle of blood-borne hepatitis C virus.

Hepatitis C virus utilizes lipid droplet for production of infectious virus.

Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor.

Synthesis and anti-HCV activity of 2',5'-deoxy-5'-phenacyladenosine analogs.

Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560.

Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG132.

HTLV-1 basic leucine-zipper factor, HBZ, interacts with MafB and suppresses transcription through a Maf recognition element.

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.

Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins.

Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms.

Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.

Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C.

Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families.

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B.

Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C.

Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses.

Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV).

Cyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target.

The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site.

In vitro models for analysis of the hepatitis C virus life cycle.

Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase.

Lipoprotein component associated with hepatitis C virus is essential for virus infectivity.

Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis.

Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.

PML tumor suppressor protein is required for HCV production.

Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells.

Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers.

Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection.

Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication.

The J6JFH1 strain of hepatitis C virus infects human B-cells with low replication efficacy.

The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA.

Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt-/JNK-PEPCK signalling pathways.

Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles.

A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors.

Apolipoprotein E, but Not Apolipoprotein B, Is Essential for Efficient Cell-to-Cell Transmission of Hepatitis C Virus.

Novel reporter system to monitor early stages of the hepatitis B virus life cycle.

Hepatitis C virus utilizes VLDLR as a novel entry pathway.

Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.

Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression.