Pepper Schedin

Department of Cell, Oregon Health and Science University

Affiliated withOregon Health and Science University

Research Area

Cancer Research

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2016

Other Publications

Article	Year
Adolescent vitamin A intake alters susceptibility to mammary carcinogenesis in the Sprague-Dawley rat. Nutrition and cancer\| PubMed ID: 12235654	2002
ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene\| PubMed ID: 14767472	2004
Multistep tumorigenesis and the microenvironment. Breast cancer research : BCR\| PubMed ID: 14979914	2004
Mammary ECM composition and function are altered by reproductive state. Molecular carcinogenesis\| PubMed ID: 15468292	2004
Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. The American journal of pathology\| PubMed ID: 16436674	2006
Pregnancy-associated breast cancer and metastasis. Nature reviews. Cancer\| PubMed ID: 16557280	2006
Inhibition of breast cancer growth and invasion by single-minded 2s. Carcinogenesis\| PubMed ID: 16840439	2007
Microenvironment of the involuting mammary gland mediates mammary cancer progression. Journal of mammary gland biology and neoplasia\| PubMed ID: 17318269	2007
Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate. The Journal of nutrition\| PubMed ID: 17513400	2007
Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. Molecular and cellular biology\| PubMed ID: 18160708	2008
Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes. Breast cancer research : BCR\| PubMed ID: 19173736	2009
Identifying significant temporal variation in time course microarray data without replicates. BMC bioinformatics\| PubMed ID: 19323838	2009
Breaking down barriers: the importance of the stromal microenvironment in acquiring invasiveness in young women's breast cancer. Breast cancer research : BCR\| PubMed ID: 19344495	2009
Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer? Journal of mammary gland biology and neoplasia\| PubMed ID: 19350209	2009
An in-solution ultrasonication-assisted digestion method for improved extracellular matrix proteome coverage. Molecular & cellular proteomics : MCP\| PubMed ID: 19351662	2009
Pregnancy and breast cancer: when they collide. Journal of mammary gland biology and neoplasia\| PubMed ID: 19381788	2009
The complexity of the relationships between age at first birth and breast cancer incidence curves implicate pregnancy in cancer initiation as well as promotion of existing lesions. Preface. Journal of mammary gland biology and neoplasia\| PubMed ID: 19437108	2009
A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats. Obesity (Silver Spring, Md.)\| PubMed ID: 19798068	2010
Quantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function. The American journal of pathology\| PubMed ID: 20042668	2010
Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. The American journal of pathology\| PubMed ID: 20110414	2010
Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells. BMC cancer\| PubMed ID: 20637104	2010
Isolation of mammary-specific extracellular matrix to assess acute cell-ECM interactions in 3D culture. Journal of mammary gland biology and neoplasia\| PubMed ID: 20680416	2010
Extracellular matrix composition reveals complex and dynamic stromal-epithelial interactions in the mammary gland. Journal of mammary gland biology and neoplasia\| PubMed ID: 20811805	2010
Editorial: The mammary stroma in normal development and function. Journal of mammary gland biology and neoplasia\| PubMed ID: 20824491	2010
Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 20926768	2010
Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harbor perspectives in biology\| PubMed ID: 20980442	2011
Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages. Journal of leukocyte biology\| PubMed ID: 21742938	2011
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. Nature medicine\| PubMed ID: 21822285	2011
Pregnancy-associated breast cancer: an entity needing refinement of the definition. Cancer\| PubMed ID: 22086839	2012
Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution. Development (Cambridge, England)\| PubMed ID: 22129827	2012
Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland. The International journal of developmental biology\| PubMed ID: 22161831	2011
Emerging targets for the prevention of pregnancy-associated breast cancer. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22374663	2012
Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 22431477	2012
Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis. Journal of proteome research\| PubMed ID: 22897585	2012
Hypothesized role of pregnancy hormones on HER2+ breast tumor development. Breast cancer research and treatment\| PubMed ID: 23135573	2013
Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer research\| PubMed ID: 23222299	2012
Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop. Journal of the National Cancer Institute\| PubMed ID: 23264680	2013
Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer. Breast cancer research and treatment\| PubMed ID: 23430224	2013
Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Hormones & cancer\| PubMed ID: 23479404	2013
Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention. Experimental cell research\| PubMed ID: 23664839	2013
Collagen architecture in pregnancy-induced protection from breast cancer. Journal of cell science\| PubMed ID: 23843613	2013
Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells. Journal of cell science\| PubMed ID: 23902685	2013
Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. eLife\| PubMed ID: 24381245	2013
Physiological COX-2 expression in breast epithelium associates with COX-2 levels in ductal carcinoma in situ and invasive breast cancer in young women. The American journal of pathology\| PubMed ID: 24518566	2014
Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling. Breast cancer research : BCR\| PubMed ID: 24678808	2014
Mammary gland involution as an immunotherapeutic target for postpartum breast cancer. Journal of mammary gland biology and neoplasia\| PubMed ID: 24952477	2014
Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer. The Journal of clinical investigation\| PubMed ID: 25133426	2014
Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression. International journal of cancer\| PubMed ID: 25187059	2015
Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium. Journal of the National Cancer Institute\| PubMed ID: 25224496	2014
Tumor mechanics and metabolic dysfunction. Free radical biology & medicine\| PubMed ID: 25532934	2015
A case-control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium. Breast cancer research : BCR\| PubMed ID: 25849024	2015
Molecular Phenotype of Breast Cancer According to Time Since Last Pregnancy in a Large Cohort of Young Women. The oncologist\| PubMed ID: 26025931	2015
Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women. Journal of the National Cancer Institute\| PubMed ID: 26085483	2015
Myoepithelial cell differentiation markers in ductal carcinoma in situ progression. The American journal of pathology\| PubMed ID: 26343330	2015
Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case-control and case-case analyses. Cancer causes & control : CCC\| PubMed ID: 26621543	2016
COX-2 modulates mammary tumor progression in response to collagen density. Breast cancer research : BCR\| PubMed ID: 27000374	2016
Myoepithelial cells in lobular carcinoma in situ: distribution and immunophenotype. Human pathology\| PubMed ID: 27195907	2016
Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments. The international journal of biochemistry & cell biology\| PubMed ID: 27771439	2016
The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis. Cancer discovery\| PubMed ID: 27974414	2016