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Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.
Neurochemistry international Apr, 2002 | Pubmed ID: 11792463
Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.
Hepatology (Baltimore, Md.) Jun, 2002 | Pubmed ID: 12029623
Cochlear abnormalities in insulin-like growth factor-1 mouse mutants.
Hearing research Aug, 2002 | Pubmed ID: 12208536
Expression and function of phospholipase A(2) in brain.
FEBS letters Oct, 2002 | Pubmed ID: 12401195
Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I.
Journal of cell science Feb, 2003 | Pubmed ID: 12508109
Cell death in the nervous system: lessons from insulin and insulin-like growth factors.
Molecular neurobiology Aug, 2003 | Pubmed ID: 14514984
Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals.
Current topics in developmental biology , 2003 | Pubmed ID: 14674481
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
The Journal of clinical investigation Mar, 2004 | Pubmed ID: 15067322
Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I.
BMC gastroenterology Jun, 2004 | Pubmed ID: 15196310
Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1.
World journal of gastroenterology Sep, 2004 | Pubmed ID: 15300898
Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.
Hearing research Oct, 2004 | Pubmed ID: 15464297
Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases.
FEBS letters Jan, 2005 | Pubmed ID: 15620691
Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action.
Advances in experimental medicine and biology , 2005 | Pubmed ID: 16370141
Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.
Current pharmaceutical design , 2007 | Pubmed ID: 17346184
A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.
The International journal of developmental biology , 2007 | Pubmed ID: 17891717
Spatial and temporal segregation of auditory and vestibular neurons in the otic placode.
Developmental biology Oct, 2008 | Pubmed ID: 18674529
RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations.
Journal of neurochemistry Jul, 2009 | Pubmed ID: 19457086
Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.
Pigment cell & melanoma research Feb, 2010 | Pubmed ID: 19843244
Direct drug application to the round window: a comparative study of ototoxicity in rats.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Nov, 2009 | Pubmed ID: 19861195
RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.
PloS one Jan, 2010 | Pubmed ID: 20111592
European scientific, ethical, and legal issues on human stem cell research and regenerative medicine.
Stem cells (Dayton, Ohio) Jun, 2010 | Pubmed ID: 20533567
A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice.
Frontiers in neuroanatomy , 2010 | Pubmed ID: 20661454
RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.
PloS one Dec, 2010 | Pubmed ID: 21203386
The role of insulin-like growth factor-I in the physiopathology of hearing.
Frontiers in molecular neuroscience , 2011 | Pubmed ID: 21845174
Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.
Molecular medicine (Cambridge, Mass.) , 2012 | Pubmed ID: 22160220
Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss.
Current drug delivery May, 2012 | Pubmed ID: 22283653
AKT signaling mediates IGF-I survival actions on otic neural progenitors.
PloS one , 2012 | Pubmed ID: 22292041
Early development of the vertebrate inner ear.
Anatomical record (Hoboken, N.J. : 2007) Nov, 2012 | Pubmed ID: 23044927
IGF-I deficiency and hearing loss: molecular clues and clinical implications.
Pediatric endocrinology reviews : PER Jul, 2013 | Pubmed ID: 23957197
Programmed cell senescence during mammalian embryonic development.
Cell Nov, 2013 | Pubmed ID: 24238962
Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.
PloS one , 2014 | Pubmed ID: 24503961
Autophagy during vertebrate development.
Cells Aug, 2012 | Pubmed ID: 24710484
Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.
Brain structure & function Nov, 2015 | Pubmed ID: 25226845
Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice.
Transgenic research Apr, 2015 | Pubmed ID: 25238791
Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2015 | Pubmed ID: 25384423
Targeting cholesterol homeostasis to fight hearing loss: a new perspective.
Frontiers in aging neuroscience , 2015 | Pubmed ID: 25688206
Swept-sine noise-induced damage as a hearing loss model for preclinical assays.
Frontiers in aging neuroscience , 2015 | Pubmed ID: 25762930
Transforming growth factor β1 inhibition protects from noise-induced hearing loss.
Frontiers in aging neuroscience , 2015 | Pubmed ID: 25852546
C-Raf deficiency leads to hearing loss and increased noise susceptibility.
Cellular and molecular life sciences : CMLS Oct, 2015 | Pubmed ID: 25975225
Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss.
Frontiers in aging neuroscience , 2015 | Pubmed ID: 26005416
Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays.
Frontiers in aging neuroscience , 2015 | Pubmed ID: 26029100
Age-regulated function of autophagy in the mouse inner ear.
Hearing research Dec, 2015 | Pubmed ID: 26235979
Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection.
Frontiers in aging neuroscience , 2015 | Pubmed ID: 26236234
Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.
The Journal of nutritional biochemistry Dec, 2015 | Pubmed ID: 26321228
Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays.
Hearing research Dec, 2015 | Pubmed ID: 26341476
Public investment in biomedical research in Europe.
Lancet (London, England) Oct, 2015 | Pubmed ID: 26460768
Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA).
Maturitas Jan, 2016 | Pubmed ID: 26520249
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.
EMBO molecular medicine 03, 2016 | Pubmed ID: 26881968
Frailty in mouse ageing: A conceptual approach.
Mechanisms of ageing and development Dec, 2016 | Pubmed ID: 27443148
Autophagy resolves early retinal inflammation in Igf1-deficient mice.
Disease models & mechanisms Sep, 2016 | Pubmed ID: 27483352
Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice.
Frontiers in aging neuroscience , 2016 | Pubmed ID: 27630560
Silvia Murillo-Cuesta*,1,2,3,
Néstor Vallecillo*,1,
Rafael Cediel1,2,4,
Adelaida M. Celaya1,2,
Luis Lassaletta3,5,
Isabel Varela-Nieto1,2,3,
Julio Contreras1,2,4
1, Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM,
2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII),
3, Instituto de Investigación Sanitaria La Paz (IdiPAZ),
4Facultad de Veterinaria, Universidad Complutense de Madrid,
5Departmento de Otorrino laringología, Hospital Universitario La Paz
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