Isabel Varela-Nieto

Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.

Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation.

Cochlear abnormalities in insulin-like growth factor-1 mouse mutants.

Expression and function of phospholipase A(2) in brain.

Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I.

Cell death in the nervous system: lessons from insulin and insulin-like growth factors.

Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals.

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.

Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I.

Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1.

Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.

Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases.

Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action.

Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.

A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.

Spatial and temporal segregation of auditory and vestibular neurons in the otic placode.

RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations.

Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.

Direct drug application to the round window: a comparative study of ototoxicity in rats.

RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

European scientific, ethical, and legal issues on human stem cell research and regenerative medicine.

A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice.

RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.

The role of insulin-like growth factor-I in the physiopathology of hearing.

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.

Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss.

AKT signaling mediates IGF-I survival actions on otic neural progenitors.

Early development of the vertebrate inner ear.

IGF-I deficiency and hearing loss: molecular clues and clinical implications.

Programmed cell senescence during mammalian embryonic development.

Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.

Autophagy during vertebrate development.

Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.

Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice.

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.

Targeting cholesterol homeostasis to fight hearing loss: a new perspective.

Swept-sine noise-induced damage as a hearing loss model for preclinical assays.

Transforming growth factor β1 inhibition protects from noise-induced hearing loss.

C-Raf deficiency leads to hearing loss and increased noise susceptibility.

Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss.

Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays.

Age-regulated function of autophagy in the mouse inner ear.

Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection.

Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.

Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays.

Public investment in biomedical research in Europe.

Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA).

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.

Frailty in mouse ageing: A conceptual approach.

Autophagy resolves early retinal inflammation in Igf1-deficient mice.

Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice.