Department of Pharmaceutical Biology and Biotechnology
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Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A.
Chemistry & biology Jul, 2005 | Pubmed ID: 16039521
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity.
Chemistry & biology Mar, 2002 | Pubmed ID: 11927254
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.
Journal of the American Chemical Society May, 2002 | Pubmed ID: 12022840
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717.
Chembiochem : a European journal of chemical biology Jan, 2003 | Pubmed ID: 12512084
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses.
Journal of the American Chemical Society Apr, 2003 | Pubmed ID: 12696864
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes.
Journal of molecular biology May, 2003 | Pubmed ID: 12742024
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.
Molecular microbiology Jul, 2003 | Pubmed ID: 12828631
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene.
FEMS microbiology letters Jan, 2004 | Pubmed ID: 14734170
Rational saccharide extension by using the natural product glycosyltransferase LanGT4.
Chembiochem : a European journal of chemical biology Mar, 2004 | Pubmed ID: 14997529
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers.
Angewandte Chemie (International ed. in English) May, 2004 | Pubmed ID: 15170316
Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization.
The Journal of antibiotics Jun, 2004 | Pubmed ID: 15323127
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.
Chemistry & biology Oct, 2004 | Pubmed ID: 15489167
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis.
Chembiochem : a European journal of chemical biology Nov, 2004 | Pubmed ID: 15515090
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.
Journal of molecular biology Jan, 2005 | Pubmed ID: 15581897
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A.
Applied and environmental microbiology Jan, 2005 | Pubmed ID: 15640214
Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.
The Journal of organic chemistry Jan, 2005 | Pubmed ID: 15651811
Novel natural compounds obtained by genome-based screening and genetic engineering.
Current opinion in drug discovery & development Mar, 2005 | Pubmed ID: 15782546
Exploiting Pseudomonas putida for drug development.
Chemistry & biology Mar, 2005 | Pubmed ID: 15797207
Generation of novel landomycins M and O through targeted gene disruption.
Chembiochem : a European journal of chemical biology Apr, 2005 | Pubmed ID: 15812784
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis.
Chembiochem : a European journal of chemical biology Aug, 2005 | Pubmed ID: 15977274
It works: combinatorial biosynthesis for generating novel glycosylated compounds.
Molecular microbiology Oct, 2005 | Pubmed ID: 16164544
Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis.
Chemistry & biology Oct, 2005 | Pubmed ID: 16242656
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis.
Chembiochem : a European journal of chemical biology Dec, 2005 | Pubmed ID: 16283688
A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912.
FEMS microbiology letters Feb, 2006 | Pubmed ID: 16448507
The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme.
The Journal of biological chemistry May, 2006 | Pubmed ID: 16537546
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis.
Journal of bacteriology Apr, 2006 | Pubmed ID: 16547054
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives.
Chemistry & biology Apr, 2006 | Pubmed ID: 16632249
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides.
Molecular bioSystems Jul, 2005 | Pubmed ID: 16880973
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).
Angewandte Chemie (International ed. in English) Nov, 2006 | Pubmed ID: 17061307
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.
Chembiochem : a European journal of chemical biology Jan, 2007 | Pubmed ID: 17139690
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
Natural product reports Feb, 2007 | Pubmed ID: 17268612
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase.
Chembiochem : a European journal of chemical biology Apr, 2007 | Pubmed ID: 17357167
A genomic screening approach to the structure-guided identification of drug candidates from natural sources.
Chembiochem : a European journal of chemical biology May, 2007 | Pubmed ID: 17407125
SorF: a glycosyltransferase with promiscuous donor substrate specificity in vitro.
Chembiochem : a European journal of chemical biology May, 2007 | Pubmed ID: 17407127
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.
Applied microbiology and biotechnology Jul, 2007 | Pubmed ID: 17497146
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.
Journal of molecular biology Sep, 2007 | Pubmed ID: 17640665
The future of natural products as a source of new antibiotics.
Current opinion in investigational drugs (London, England : 2000) Aug, 2007 | Pubmed ID: 17668363
Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes.
Archives of microbiology Feb, 2008 | Pubmed ID: 17786405
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering.
Chembiochem : a European journal of chemical biology Feb, 2008 | Pubmed ID: 18157854
Functional expression of the Cre recombinase in actinomycetes.
Applied microbiology and biotechnology Apr, 2008 | Pubmed ID: 18299828
Glycosyltransferases, important tools for drug design.
Current topics in medicinal chemistry , 2008 | Pubmed ID: 18473892
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern.
Current topics in medicinal chemistry , 2008 | Pubmed ID: 18473893
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136.
FEMS microbiology letters Aug, 2008 | Pubmed ID: 18537830
Marker removal from actinomycetes genome using Flp recombinase.
Gene Aug, 2008 | Pubmed ID: 18550297
Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity.
Applied microbiology and biotechnology Aug, 2008 | Pubmed ID: 18553079
Features and applications of bacterial glycosyltransferases: current state and prospects.
Applied microbiology and biotechnology Oct, 2008 | Pubmed ID: 18777021
Engineering a function into a glycosyltransferase.
Chemistry & biology Jan, 2009 | Pubmed ID: 19171303
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin.
Chembiochem : a European journal of chemical biology Apr, 2009 | Pubmed ID: 19266534
Genes and enzymes involved in bacterial isoprenoid biosynthesis.
Current opinion in chemical biology Apr, 2009 | Pubmed ID: 19318289
Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis.
Applied microbiology and biotechnology Jul, 2009 | Pubmed ID: 19352642
Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds.
Methods in enzymology , 2009 | Pubmed ID: 19374988
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains.
Chembiochem : a European journal of chemical biology May, 2009 | Pubmed ID: 19384899
A bacterial glycosyltransferase gene toolbox: generation and applications.
Phytochemistry Oct-Nov, 2009 | Pubmed ID: 19559449
Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117.
Applied microbiology and biotechnology Jan, 2010 | Pubmed ID: 19585113
Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators.
The Journal of antibiotics Aug, 2009 | Pubmed ID: 19609289
Functions of genes and enzymes involved in phenalinolactone biosynthesis.
Chembiochem : a European journal of chemical biology Jul, 2010 | Pubmed ID: 20540056
Combinatorial and synthetic biosynthesis in actinomycetes.
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles , 2010 | Pubmed ID: 20556678
Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products.
Topics in current chemistry , 2010 | Pubmed ID: 21495258
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase.
Chemistry & biology Apr, 2011 | Pubmed ID: 21513888
Genome sequence of Streptomyces sp. strain Tü6071.
Journal of bacteriology Aug, 2011 | Pubmed ID: 21705604
Cloning and heterologous expression of three type II PKS gene clusters from Streptomyces bottropensis.
Chembiochem : a European journal of chemical biology Jan, 2012 | Pubmed ID: 22162248
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors.
AMB Express Jan, 2012 | Pubmed ID: 22214346
Site-specific recombination strategies for engineering actinomycete genomes.
Applied and environmental microbiology Mar, 2012 | Pubmed ID: 22247163
SnoaW/SnoaL2: a different two-component monooxygenase.
Chemistry & biology May, 2012 | Pubmed ID: 22633406
Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae.
BMC genomics Sep, 2012 | Pubmed ID: 22958348
A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis.
FEMS microbiology letters May, 2013 | Pubmed ID: 23480614
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.
Applied and environmental microbiology Sep, 2013 | Pubmed ID: 23793643
Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production.
Current microbiology Feb, 2014 | Pubmed ID: 24057064
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene.
Chemistry & biology Oct, 2013 | Pubmed ID: 24120331
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.
Open biology Oct, 2013 | Pubmed ID: 24153004
Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628.
Applied microbiology and biotechnology Jun, 2014 | Pubmed ID: 24509772
Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8.
Chembiochem : a European journal of chemical biology Mar, 2014 | Pubmed ID: 24554499
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae.
BMC genomics Oct, 2014 | Pubmed ID: 25301375
Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.
Angewandte Chemie (International ed. in English) Feb, 2015 | Pubmed ID: 25581707
Functional characterization of different ORFs including luciferase-like monooxygenase genes from the mensacarcin gene cluster.
Chembiochem : a European journal of chemical biology May, 2015 | Pubmed ID: 25907804
The Gene bldA, a regulator of morphological differentiation and antibiotic production in streptomyces.
Archiv der Pharmazie Jul, 2015 | Pubmed ID: 25917027
Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains.
Chembiochem : a European journal of chemical biology Oct, 2015 | Pubmed ID: 26255983
Minimum Information about a Biosynthetic Gene cluster.
Nature chemical biology Sep, 2015 | Pubmed ID: 26284661
Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule.
Chembiochem : a European journal of chemical biology Nov, 2015 | Pubmed ID: 26374477
Bacillus cereus efflux protein BC3310 - a multidrug transporter of the unknown major facilitator family, UMF-2.
Frontiers in microbiology , 2015 | Pubmed ID: 26528249
New Simocyclinones: Surprising Evolutionary and Biosynthetic Insights.
ACS chemical biology Jan, 2016 | Pubmed ID: 26566170
StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes.
Nucleic acids research Jan, 2016 | Pubmed ID: 26615197
Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628.
Journal of industrial microbiology & biotechnology Apr, 2016 | Pubmed ID: 26790416
An influence of the copy number of biosynthetic gene clusters on the production level of antibiotics in a heterologous host.
Journal of biotechnology Aug, 2016 | Pubmed ID: 27264245
Thailandins A and B, New Polyene Macrolactone Compounds Isolated from Actinokineospora bangkokensis Strain 44EHW(T), Possessing Antifungal Activity against Anthracnose Fungi and Pathogenic Yeasts.
Journal of agricultural and food chemistry Jun, 2016 | Pubmed ID: 27267862
The Draft Genome Sequence of Actinokineospora bangkokensis 44EHW(T) Reveals the Biosynthetic Pathway of the Antifungal Thailandin Compounds with Unusual Butylmalonyl-CoA Extender Units.
Molecules (Basel, Switzerland) Nov, 2016 | Pubmed ID: 27886115
Selection of an efficient promoter and its application in toyocamycin production improvement in Streptomyces diastatochromogenes 1628.
World journal of microbiology & biotechnology Feb, 2017 | Pubmed ID: 28058639
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