School of Biological Sciences
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Normal ovarian surface epithelium.
Cancer treatment and research , 2002 | Pubmed ID: 11775449
Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin.
The Journal of cell biology Jun, 2003 | Pubmed ID: 12810698
Ovarian surface epithelium: family history and early events in ovarian cancer.
Reproductive biology and endocrinology : RB&E Oct, 2003 | Pubmed ID: 14609432
Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line.
Differentiation; research in biological diversity Apr, 2004 | Pubmed ID: 15157238
Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation.
Experimental cell research Sep, 2004 | Pubmed ID: 15302591
Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase A pathway.
The Journal of biological chemistry Apr, 2005 | Pubmed ID: 15701645
Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies.
Gynecologic oncology Jul, 2005 | Pubmed ID: 15913737
Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells.
Endocrinology May, 2006 | Pubmed ID: 16469801
Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells.
Endocrinology Sep, 2006 | Pubmed ID: 16777976
Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 up-regulation via the beta-catenin/T-cell factor signaling pathway.
Molecular endocrinology (Baltimore, Md.) Dec, 2006 | Pubmed ID: 16945989
Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells.
The Journal of biological chemistry Nov, 2006 | Pubmed ID: 17008323
Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9.
Cancer research Nov, 2006 | Pubmed ID: 17108127
Role of endocrine and growth factors on the ovarian surface epithelium.
The journal of obstetrics and gynaecology research Feb, 2007 | Pubmed ID: 17212660
Gonadotropins and ovarian cancer.
Endocrine reviews Jun, 2007 | Pubmed ID: 17463396
Synergistic effects of epidermal growth factor and hepatocyte growth factor on human ovarian cancer cell invasion and migration: role of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase.
Endocrinology Nov, 2007 | Pubmed ID: 17673518
CpG/CpNpG motifs in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes.
FEBS letters Oct, 2007 | Pubmed ID: 17826769
Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion.
Endocrine Jun, 2007 | Pubmed ID: 17906381
Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells.
Experimental cell research May, 2008 | Pubmed ID: 18394600
Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha.
Molecular endocrinology (Baltimore, Md.) Sep, 2008 | Pubmed ID: 18550773
p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells.
Cancer research Aug, 2008 | Pubmed ID: 18701475
HGF/MET signaling in ovarian cancer.
Current molecular medicine Sep, 2008 | Pubmed ID: 18781954
Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK.
FEBS letters Oct, 2008 | Pubmed ID: 18789327
Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues.
The FEBS journal Nov, 2008 | Pubmed ID: 18959738
An experimental model of ovarian carcinoma: more than just genetics.
Cell cycle (Georgetown, Tex.) Jan, 2010 | Pubmed ID: 20061793
c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.
Neoplasia (New York, N.Y.) Feb, 2010 | Pubmed ID: 20126471
Gonadotropins induce tumor cell migration and invasion by increasing cyclooxygenases expression and prostaglandin E(2) production in human ovarian cancer cells.
Endocrinology Jul, 2010 | Pubmed ID: 20392831
Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1.
Cardiovascular research Feb, 2011 | Pubmed ID: 20855522
Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1α to promote angiogenesis.
Angiogenesis Dec, 2011 | Pubmed ID: 21964931
Nur77: a potential therapeutic target in cancer.
Expert opinion on therapeutic targets Jun, 2012 | Pubmed ID: 22537097
p70 S6 kinase and actin dynamics: A perspective.
Spermatogenesis Jan, 2012 | Pubmed ID: 22553489
Exploiting p70 S6 kinase as a target for ovarian cancer.
Expert opinion on therapeutic targets Jun, 2012 | Pubmed ID: 22564017
Human female reproductive tract epithelial cell culture.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23097117
Targeting Gonadotropin-releasing Hormone Receptor Inhibits the Early Step of Ovarian Cancer Metastasis by Modulating Tumor-mesothelial Adhesion.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2012 | Pubmed ID: 23164934
BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis.
Cancer letters Apr, 2014 | Pubmed ID: 24378767
Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview.
Natural product reports Feb, 2015 | Pubmed ID: 25347695
Loss of Sprouty2 in human high-grade serous ovarian carcinomas promotes EGF-induced E-cadherin down-regulation and cell invasion.
FEBS letters Jan, 2015 | Pubmed ID: 25533808
Exosomes: Emerging biomarkers and targets for ovarian cancer.
Cancer letters Oct, 2015 | Pubmed ID: 26189430
Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress.
Scientific reports Jun, 2016 | Pubmed ID: 27245437
Shan-Shan Li*,1,
Carman K. M. Ip*,1,
Matthew Y. H. Tang*,2,
Samuel K. H. Sy2,
Susan Yung3,
Tak-Mao Chan3,
Mengsu Yang4,
Ho Cheung Shum2,
Alice S.T. Wong1
1School of Biological Sciences, University of Hong Kong,
2Department of Mechanical Engineering, University of Hong Kong,
3Department of Medicine, University of Hong Kong,
4Department of Biomedical Sciences, Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institutes of City University of Hong Kong
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